Publications by authors named "Martin Sims"

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The IAP antagonist tolinapant enhances the anti-tumor activity of cell therapies.
Keisuke Tazuru, Masayuki Sone, Hiroki Akamine, Yosuke Kogue, Martin J Sims

Eur J Pharmacol· May 2025

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The identification of functional regions of MEK1 using CRISPR tiling screens.
Zhiqiang Zhang, Barbara Abreu, Jessica L Brothwood, John Alexander, Martin J Sims

Commun Biol· April 2025

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Epigenetic Priming by Hypomethylation Enhances the Immunogenic Potential of Tolinapant in T-cell Lymphoma.
George A Ward, Zhiqiang Zhang, Simone Jueliger, Ilya S Potapov, Matthew P Davis, Martin Sims

Cancer Res Commun· June 2024

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Antagonism of inhibitors of apoptosis proteins reveals a novel, immune response-based therapeutic approach for T-cell lymphoma.
Nicola Ferrari, George Ward, Christina Gewinner, Matthew P Davis, Simone Jueliger, Martin J Sims

Blood Adv· October 2021

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Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance.
Laura Ramos Garcia, Tencho Tenev, Richard Newman, Rachel O Haich, Gianmaria Liccardi, Martin Sims

Nat Commun· June 2021

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Structure-based optimisation of orally active & reversible MetAP-2 inhibitors maintaining a tight 'molecular budget'.
David J Hirst, Martin Brandt, Gordon Bruton, Erica Christodoulou, Leanne Cutler, Martin Sims

Bioorg Med Chem Lett· November 2020

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Characterisation of phosphorylated nucleotides by collisional and electron-based tandem mass spectrometry.
Andrew T Ball, Aruna S Prakash, Anthony W T Bristow, Martin Sims, Jackie A Mosely

Rapid Commun Mass Spectrom· October 2016

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Applicability of gas chromatography/quadrupole-Orbitrap mass spectrometry in support of pharmaceutical research and development.
Stephen Baldwin, Tony Bristow, Andrew Ray, Karen Rome, Natalie Sanderson, Martin Sims

Rapid Commun Mass Spectrom· April 2016

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Using electron induced dissociation (EID) on an LC time-scale to characterize a mixture of analogous small organic molecules.
Aruna S Prakash, Michael J P Smith, Zied Kaabia, Glenn Hurst, Ci Yan, Martin Sims

J Am Soc Mass Spectrom· May 2012

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Electron-induced dissociation of singly charged organic cations as a tool for structural characterization of pharmaceutical type molecules.
Jackie A Mosely, Michael J P Smith, Aruna S Prakash, Martin Sims, Anthony W T Bristow

Anal Chem· June 2011

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Mechanistic medicine: novel strategies for clinical trials.
Andrea A Itano, Martin J Sims, Gerald Siu

Autoimmunity· November 2010

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The application of gas chromatography/atmospheric pressure chemical ionisation time-of-flight mass spectrometry to impurity identification in Pharmaceutical Development.
Tony Bristow, Mark Harrison, Martin Sims

Rapid Commun Mass Spectrom· June 2010

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N-4-Pyrimidinyl-1H-indazol-4-amine inhibitors of Lck: indazoles as phenol isosteres with improved pharmacokinetics.
Paul Bamborough, Richard M Angell, Inder Bhamra, David Brown, James Bull, Martin J Sims

Bioorg Med Chem Lett· August 2007

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Ligation of CD28 stimulates the formation of a multimeric signaling complex involving grb-2-associated binder 2 (gab2), SRC homology phosphatase-2, and phosphatidylinositol 3-kinase: evidence that negative regulation of CD28 signaling requires the gab2 pleckstrin homology domain.
Richard V Parry, Gillian C Whittaker, Martin Sims, Christine E Edmead, Melanie J Welham

J Immunol· January 2006

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