Publications by authors named "Masashi Hyuga"

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Molecular Mechanism of Anti-SARS-CoV-2 Activity of Ephedra Herb Macromolecule Condensed-Tannin Contained in Ephedrine Alkaloids-Free Ephedra Herb Extract.
Masashi Hyuga, Nahoko Uchiyama, Morio Yoshimura, Yoshiaki Amakura, Sumiko Hyuga

Chem Pharm Bull (Tokyo)· July 2025

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The Antiviral Effect of Ephedrine Alkaloids-Free Ephedra Herb Extract, EFE, on Murine Coronavirus Growth in the Lung and Liver of Infected Mice.
Akinori Nishi, Sumiko Hyuga, Masashi Hyuga, Masashi Uema, Nahoko Uchiyama

Microorganisms· April 2025

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Safety and Efficacy of Ephedrine Alkaloids-Free Ephedra Herb Extract (EFE) for Mild COVID-19: A Double-Blind, Placebo-Controlled, Randomized Comparative Trial.
Hiroshi Odaguchi, Sumiko Hyuga, Mariko Sekine, Hirofumi Michimae, Masashi Hyuga

Microorganisms· March 2025

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Antiviral Effect of Ephedrine Alkaloids-Free Ephedra Herb Extract against SARS-CoV-2 In Vitro.
Masashi Uema, Masashi Hyuga, Kenzo Yonemitsu, Sumiko Hyuga, Yoshiaki Amakura

Microorganisms· February 2023

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Overlooked switch from transient sedation to sustained excitement in the Biphasic effects of Ephedra Herb extract administered orally to mice.
Xuedan Huang, Sumiko Hyuga, Yoshiaki Amakura, Masashi Hyuga, Nahoko Uchiyama

J Ethnopharmacol· January 2023

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Recent Achievements and Current Interests in Research on the Characterization and Quality Control of Biopharmaceuticals in Japan.
Akiko Ishii-Watabe, Hiroko Shibata, Hiroyuki Suetomo, Yosuke Ikeda, Srivalli Telikepalli, Masashi Hyuga

J Pharm Sci· May 2020

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Quality Evaluation and Characterization of Fractions with Biological Activity from Ephedra Herb Extract and Ephedrine Alkaloids-Free Ephedra Herb Extract.
Morio Yoshimura, Yoshiaki Amakura, Sumiko Hyuga, Masashi Hyuga, Shunsuke Nakamori

Chem Pharm Bull (Tokyo)· March 2020

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[The Adverse Effects of Ephedra Herb and the Safety of Ephedrine Alkaloids-free Ephedra Herb Extract (EFE)].
Hiroshi Odaguchi, Sumiko Hyuga, Mariko Sekine, Shunsuke Nakamori, Hiroaki Takemoto, Masashi Hyuga

Yakugaku Zasshi· February 2020

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Analgesic Effects of Ephedra Herb Extract, Ephedrine Alkaloids-Free Ephedra Herb Extract, Ephedrine, and Pseudoephedrine on Formalin-Induced Pain.
Shunsuke Nakamori, Jun Takahashi, Sumiko Hyuga, Jinwei Yang, Hiroaki Takemoto, Masashi Hyuga

Biol Pharm Bull· January 2020

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Non-alkaloidal composition of Ephedra Herb is influenced by differences in habitats.
Naohiro Oshima, Tadatoshi Yamashita, Nahoko Uchiyama, Sumiko Hyuga, Masashi Hyuga

J Nat Med· January 2019

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Ephedrine Alkaloids-Free Ephedra Herb Extract, EFE, Has No Adverse Effects Such as Excitation, Insomnia, and Arrhythmias.
Hiroaki Takemoto, Jun Takahashi, Sumiko Hyuga, Hiroshi Odaguchi, Nahoko Uchiyama, Masashi Hyuga

Biol Pharm Bull· August 2018

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A Double-Blind, Randomized, Crossover Comparative Study for Evaluating the Clinical Safety of Ephedrine Alkaloids-Free Ephedra Herb Extract (EFE).
Hiroshi Odaguchi, Mariko Sekine, Sumiko Hyuga, Toshihiko Hanawa, Keika Hoshi, Masashi Hyuga

Evid Based Complement Alternat Med· August 2018

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Correction to: Ephedra Herb extract activates/desensitizes transient receptor potential vanilloid 1 and reduces capsaicin-induced pain.
Shunsuke Nakamori, Jun Takahashi, Sumiko Hyuga, Toshiko Tanaka-Kagawa, Hideto Jinno, Masashi Hyuga

J Nat Med· March 2018

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Two flavone C-glycosides as quality control markers for the manufacturing process of ephedrine alkaloids-free Ephedra Herb extract (EFE) as a crude drug preparation.
Naohiro Oshima, Takuro Maruyama, Tadatoshi Yamashita, Nahoko Uchiyama, Yoshiaki Amakura, Sumiko Hyuga, Masashi Hyuga

J Nat Med· January 2018

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Recent Topics of Research in the Characterization and Quality Control of Biopharmaceuticals in Japan.
Akiko Ishii-Watabe, Hiroko Shibata, Akira Harazono, Masashi Hyuga, Masato Kiyoshi

J Pharm Sci· December 2017

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Ephedra Herb extract activates/desensitizes transient receptor potential vanilloid 1 and reduces capsaicin-induced pain.
Shunsuke Nakamori, Jun Takahashi, Sumiko Hyuga, Toshiko Tanaka-Kagawa, Hideto Jinno, Masashi Hyuga

J Nat Med· January 2017

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Ephedrine alkaloids-free Ephedra Herb extract: a safer alternative to ephedra with comparable analgesic, anticancer, and anti-influenza activities.
Sumiko Hyuga, Masashi Hyuga, Naohiro Oshima, Takuro Maruyama, Hiroyuki Kamakura

J Nat Med· July 2016

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Efficiently prepared ephedrine alkaloids-free Ephedra Herb extract: a putative marker and antiproliferative effects.
Naohiro Oshima, Tadatoshi Yamashita, Sumiko Hyuga, Masashi Hyuga, Hiroyuki Kamakura

J Nat Med· July 2016

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Ephedrae herba stimulates hepatocyte growth factor-induced MET endocytosis and downregulation via early/late endocytic pathways in gefitinib-resistant human lung cancer cells.
Yukio Nishimura, Sumiko Hyuga, Soichi Takiguchi, Masashi Hyuga, Kazuyuki Itoh

Int J Oncol· May 2016

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Herbacetin, a constituent of ephedrae herba, suppresses the HGF-induced motility of human breast cancer MDA-MB-231 cells by inhibiting c-Met and Akt phosphorylation.
Sumiko Hyuga, Masashi Hyuga, Morio Yoshimura, Yoshiaki Amakura, Yukihiro Goda

Planta Med· November 2013

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Characterization of phenolic constituents from ephedra herb extract.
Yoshiaki Amakura, Morio Yoshimura, Saori Yamakami, Takashi Yoshida, Daigo Wakana, Masashi Hyuga, Sumiko Hyuga

Molecules· May 2013

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Effects of Kampo medicines on MDR-1-mediated multidrug resistance in human hepatocellular carcinoma HuH-7/PTX cells.
Sumiko Hyuga, Masumi Shiraishi, Atsushi Hori, Masashi Hyuga, Toshihiko Hanawa

Biol Pharm Bull· March 2013

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Annexin A3 expression increases in hepatocytes and is regulated by hepatocyte growth factor in rat liver regeneration.
Mizuho Harashima, Kayo Harada, Yoshimasa Ito, Masashi Hyuga, Taiichiro Seki

J Biochem· April 2008

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Change in annexin A3 expression by regulatory factors of hepatocyte growth in primary cultured rat hepatocytes.
Mizuho Harashima, Shingo Niimi, Hitomi Koyanagi, Masashi Hyuga, Seiji Noma

Biol Pharm Bull· July 2006

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Thrombomodulin enhances the invasive activity of mouse mammary tumor cells.
Shingo Niimi, Mizuho Harashima, Kazuko Takayama, Mayumi Hara, Masashi Hyuga

J Biochem· May 2005

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