Publications by authors named "Mathew D Littlejohn"

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An Increase in Male Recombination Rate With Age in Dairy Cattle Is Heritable and Polygenic.
Evelyn Jade, Mathew D Littlejohn, Katie Eketone, Richard J Spelman, Jessica Stapley

J Anim Breed Genet· January 2026

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Structural and epistatic regulatory variants cause hallmark white spotting in cattle.
Swati Jivanji, Emma Wilkinson, Lijing Tang, Kathryn M Tiplady, Anna Yeates, Mathew D Littlejohn

Sci Adv· November 2025

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Survey of functional Mendelian variants in New Zealand Huntaway and Heading dog breeds.
Florence Smith, Thomas Lopdell, Melissa Stephen, Millicent Henry, Keren Dittmer, Mathew D Littlejohn

Anim Genet· October 2025

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An integrative approach to prioritize candidate causal genes for complex traits in cattle.
Mohammad Ghoreishifar, Iona M Macleod, Amanda J Chamberlain, Zhiqian Liu, Thomas J Lopdell, Mathew D Littlejohn

PLoS Genet· May 2025

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Comparison of genomic prediction accuracies in dairy cattle lactation traits using five classes of functional variants versus generic SNP.
Setegn Worku Alemu, Thomas J Lopdell, Alexander J Trevarton, Russell G Snell, Mathew D Littlejohn

Genet Sel Evol· April 2025

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Allele-specific binding variants causing ChIP-seq peak height of histone modification are not enriched in expression QTL annotations.
Mohammad Ghoreishifar, Amanda J Chamberlain, Ruidong Xiang, Claire P Prowse-Wilkins, Thomas J Lopdell, Mathew D Littlejohn

Genet Sel Evol· June 2024

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A common regulatory haplotype doubles lactoferrin concentration in milk.
Thomas J Lopdell, Alexander J Trevarton, Janelle Moody, Claire Prowse-Wilkins, Sarah Knowles, Mathew D Littlejohn

Genet Sel Evol· March 2024

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A frameshift-deletion mutation in Reelin causes cerebellar hypoplasia in White Swiss Shepherd dogs.
Mathew D Littlejohn, Nick Sneddon, Keren Dittmer, Mike Keehan, Melissa Stephen

Anim Genet· October 2023

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Development of SpCas9-expressing bovine mammary epithelial cell lines.
Alexander J Trevarton, Emily R Mears, Janelle Moody, Thomas J Lopdell, Thaize Q Chometon, Mathew D Littlejohn

In Vitro Cell Dev Biol Anim· March 2023

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Genetic variation in histone modifications and gene expression identifies regulatory variants in the mammary gland of cattle.
Claire P Prowse-Wilkins, Thomas J Lopdell, Ruidong Xiang, Christy J Vander Jagt, Mathew D Littlejohn

BMC Genomics· December 2022

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Comparison of the genetic characteristics of directly measured and Fourier-transform mid-infrared-predicted bovine milk fatty acids and proteins.
Kathryn M Tiplady, Thomas J Lopdell, Richard G Sherlock, Thomas J J Johnson, Richard J Spelman, Mathew D Littlejohn

J Dairy Sci· November 2022

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Pathology of the peripheral neuropathy Charcot-Marie-Tooth disease type 4H in Holstein Friesian cattle with a splice site mutation in .
Keren E Dittmer, Catherine Neeley, Matthew R Perrott, Edwardo Reynolds, Dorian J Garrick, Mathew D Littlejohn

Vet Pathol· May 2022

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Screening for phenotypic outliers identifies an unusually low concentration of a β-lactoglobulin B protein isoform in bovine milk caused by a synonymous SNP.
Stephen R Davis, Hamish E Ward, Van Kelly, David Palmer, Alexandra E Ankersmit-Udy, Mathew D Littlejohn

Genet Sel Evol· March 2022

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A Capra hircus chromosome 19 locus linked to milk production influences mammary conformation.
Andrew Jiang, Alex Ankersmit-Udy, Sally-Anne Turner, Megan Scholtens, Mathew D Littlejohn

J Anim Sci Biotechnol· February 2022

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Non-additive QTL mapping of lactation traits in 124,000 cattle reveals novel recessive loci.
Edwardo G M Reynolds, Thomas Lopdell, Yu Wang, Kathryn M Tiplady, Chad S Harland, Mathew D Littlejohn

Genet Sel Evol· January 2022

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Non-additive association analysis using proxy phenotypes identifies novel cattle syndromes.
Edwardo G M Reynolds, Catherine Neeley, Thomas J Lopdell, Michael Keehan, Keren Dittmer, Mathew D Littlejohn

Nat Genet· July 2021

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Sequence-based genome-wide association study of individual milk mid-infrared wavenumbers in mixed-breed dairy cattle.
Kathryn M Tiplady, Thomas J Lopdell, Edwardo Reynolds, Richard G Sherlock, Michael Keehan, Mathew D Littlejohn

Genet Sel Evol· July 2021

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A new mechanism for a familiar mutation - bovine DGAT1 K232A modulates gene expression through multi-junction exon splice enhancement.
Tania Fink, Thomas J Lopdell, Kathryn Tiplady, Renee Handley, Thomas J J Johnson, Mathew D Littlejohn

BMC Genomics· August 2020

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Genome-wide association analysis reveals QTL and candidate mutations involved in white spotting in cattle.
Swati Jivanji, Gemma Worth, Thomas J Lopdell, Anna Yeates, Christine Couldrey, Mathew D Littlejohn

Genet Sel Evol· November 2019

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Widespread -regulation of RNA editing in a large mammal.
Thomas J Lopdell, Victoria Hawkins, Christine Couldrey, Kathryn Tiplady, Stephen R Davis, Mathew D Littlejohn

RNA· March 2019

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Multiple QTL underlie milk phenotypes at the CSF2RB locus.
Thomas J Lopdell, Kathryn Tiplady, Christine Couldrey, Thomas J J Johnson, Michael Keehan, Mathew D Littlejohn

Genet Sel Evol· January 2019

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Identification of an immune modulation locus utilising a bovine mammary gland infection challenge model.
Mathew D Littlejohn, Sally-Anne Turner, Caroline G Walker, Sarah D Berry, Kathryn Tiplady

J Dairy Res· May 2018

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DNA and RNA-sequence based GWAS highlights membrane-transport genes as key modulators of milk lactose content.
Thomas J Lopdell, Kathryn Tiplady, Maksim Struchalin, Thomas J J Johnson, Michael Keehan, Mathew D Littlejohn

BMC Genomics· December 2017

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Functional confirmation of PLAG1 as the candidate causative gene underlying major pleiotropic effects on body weight and milk characteristics.
Tania Fink, Kathryn Tiplady, Thomas Lopdell, Thomas Johnson, Russell G Snell, Mathew D Littlejohn

Sci Rep· March 2017

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Sequence-based Association Analysis Reveals an MGST1 eQTL with Pleiotropic Effects on Bovine Milk Composition.
Mathew D Littlejohn, Kathryn Tiplady, Tania A Fink, Klaus Lehnert, Thomas Lopdell

Sci Rep· May 2016

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