Publications by authors named "Matt Sinclair"

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Drug-bound outward-facing conformation of a heterodimeric ABC exporter suggests a putative mechanism of drug translocation.
Qingyu Tang, Matt Sinclair, Paola Bisignano, Yunsen Zhang, Emad Tajkhorshid

Nat Commun· November 2025

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Lipid-mediated mechanism of drug extrusion by a heterodimeric ABC exporter.
Qingyu Tang, Matt Sinclair, Paola Bisignano, Yunsen Zhang, Emad Tajkhorshid

bioRxiv· February 2025

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The Role of Protein-Lipid Interactions in Priming the Bacterial Translocon.
Matt Sinclair, Emad Tajkhorshid

Membranes (Basel)· November 2024

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A Gram-negative-selective antibiotic that spares the gut microbiome.
Kristen A Muñoz, Rebecca J Ulrich, Archit K Vasan, Matt Sinclair, Po-Chao Wen

Nature· June 2024

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WSB1/2 target chromatin-bound lysine-methylated RelA for proteasomal degradation and NF-κB termination.
Jie Zhang, Yuanyuan Yu, Xiuqun Zou, Yaning Du, Qiankun Liang, Matt Sinclair

Nucleic Acids Res· May 2024

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Integrative analysis of pathogenic variants in glucose-6-phosphatase based on an AlphaFold2 model.
Matt Sinclair, Richard A Stein, Jonathan H Sheehan, Emily M Hawes, Richard M O'Brien

PNAS Nexus· February 2024

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Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter.
Qingyu Tang, Matt Sinclair, Hale S Hasdemir, Richard A Stein, Erkan Karakas

Nat Commun· November 2023

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Molecular mechanisms of catalytic inhibition for active site mutations in glucose-6-phosphatase catalytic subunit 1 linked to glycogen storage disease.
Matt Sinclair, Richard A Stein, Jonathan H Sheehan, Emily M Hawes, Richard M O'Brien

bioRxiv· August 2023

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Asymmetric conformations and lipid interactions shape the ATP-coupled cycle of a heterodimeric ABC transporter.
Qingyu Tang, Matt Sinclair, Hale S Hasdemir, Richard Stein, Erkan Karakas

bioRxiv· July 2023

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