Publications by authors named "Matthew Cyr"

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Improving dual targeting selectivity in T-cell engagers via synapse-gated and affinity-tuned trispecific antibody design.
Peng Zhao, John Schardt, Chi-I Chiang, Pooja Shah, Gee Sung Eun, Matthew Cyr

MAbs· December 2025

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Cloning, Expression, and Purification of Phage Display-Selected Fab for Biophysical and Biological Studies.
Matthew G Cyr, Haiyong Peng, Christoph Rader

Cold Spring Harb Protoc· October 2024

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Siglec-6 as a therapeutic target for cell migration and adhesion in chronic lymphocytic leukemia.
Jessica Nunes, Rakeb Tafesse, Charlene Mao, Matthew Purcell, Xiaokui Mo, Matthew G Cyr

Nat Commun· June 2024

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Applying single-cell highly multiplexed secretome proteomics to characterize immunotherapeutic products and predict clinical responses.
Weiming Ni, Edward X Han, Matthew Cyr, Sean Mackay, Jing Zhou

Proteomics· July 2023

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Concerted Antibody and Antigen Discovery by Differential Whole-cell Phage Display Selections and Multi-omic Target Deconvolution.
Matthew G Cyr, Henry D Wilson, Anna-Lena Spierling, Jing Chang, Haiyong Peng

J Mol Biol· May 2023

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Effector Memory-Expressing CD45RA (TEMRA) CD8 T Cells from Kidney Transplant Recipients Exhibit Enhanced Purinergic P2X4 Receptor-Dependent Proinflammatory and Migratory Responses.
Tra-My Doan Ngoc, Gaëlle Tilly, Richard Danger, Orianne Bonizec, Christophe Masset, Matthew Cyr

J Am Soc Nephrol· December 2022

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Patient-derived Siglec-6-targeting antibodies engineered for T-cell recruitment have potential therapeutic utility in chronic lymphocytic leukemia.
Matthew G Cyr, Maissa Mhibik, Junpeng Qi, Haiyong Peng, Jing Chang

J Immunother Cancer· November 2022

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Single-cell polyfunctional proteomics of CD4 cells from patients with AML predicts responses to anti-PD-1-based therapy.
Hussein A Abbas, Zoe Alaniz, Sean Mackay, Matthew Cyr, Jing Zhou

Blood Adv· November 2021

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Siglec-6 is a target for chimeric antigen receptor T-cell treatment of chronic lymphocytic leukemia.
Damian Kovalovsky, Jeong Heon Yoon, Matthew G Cyr, Samantha Simon, Elisaveta Voynova

Leukemia· September 2021

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Structure-Based Engineering of Irreversible Inhibitors against Histone Lysine Demethylase KDM5A.
John R Horton, Clayton B Woodcock, Qin Chen, Xu Liu, Xing Zhang, Matthew Cyr

J Med Chem· December 2018

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Siglec-6 on Chronic Lymphocytic Leukemia Cells Is a Target for Post-Allogeneic Hematopoietic Stem Cell Transplantation Antibodies.
Jing Chang, Haiyong Peng, Brian C Shaffer, Sivasubramanian Baskar, Ina C Wecken, Matthew G Cyr

Cancer Immunol Res· September 2018

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A widely-applicable high-throughput cellular thermal shift assay (CETSA) using split Nano Luciferase.
Natalia J Martinez, Rosita R Asawa, Matthew G Cyr, Alexey Zakharov, Daniel J Urban

Sci Rep· June 2018

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Crystal structure of full-length Zika virus NS5 protein reveals a conformation similar to Japanese encephalitis virus NS5.
Anup K Upadhyay, Matthew Cyr, Kenton Longenecker, Rakesh Tripathi, Chaohong Sun

Acta Crystallogr F Struct Biol Commun· March 2017

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