Publications by authors named "Matthew D Chuba"

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Discovery of 6-Fluoro-5-{4-[(5-fluoro-2-methyl-3-oxo-3,4-dihydroquinoxalin-6-yl)methyl]piperazin-1-yl}--methylpyridine-2-carboxamide (AZD9574): A CNS-Penetrant, PARP1-Selective Inhibitor.
Jeffrey W Johannes, Amber Y S Balazs, Derek Barratt, Michal Bista, Matthew D Chuba

J Med Chem· December 2024

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Catalytic σ-Bond Annulation with Ambiphilic Organohalides Enabled by β-X Elimination.
Hui-Qi Ni, Jing-Cheng Dai, Shouliang Yang, Richard P Loach, Matthew D Chuba

Angew Chem Int Ed Engl· August 2023

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Discovery of 5-{4-[(7-Ethyl-6-oxo-5,6-dihydro-1,5-naphthyridin-3-yl)methyl]piperazin-1-yl}--methylpyridine-2-carboxamide (AZD5305): A PARP1-DNA Trapper with High Selectivity for PARP1 over PARP2 and Other PARPs.
Jeffrey W Johannes, Amber Balazs, Derek Barratt, Michal Bista, Matthew D Chuba

J Med Chem· October 2021

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