Publications by authors named "Matthew D Hirschey"

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Targeting androgen receptor signaling to enhance cancer immunotherapy.
David A Bader, Binita Chakraborty, Donald P McDonnell, Matthew D Hirschey

Trends Pharmacol Sci· December 2025

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Pathway coessentiality mapping reveals complex II is required for de novo purine biosynthesis in acute myeloid leukaemia.
Amy E Stewart, Derek K Zachman, Pol Castellano-Escuder, Lois M Kelly, Ben Zolyomi, Matthew D Hirschey

Nat Metab· December 2025

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Cysteine S-acetylation is a widespread post-translational modification on metabolic proteins.
E Keith Keenan, Akshay Bareja, Yannie Lam, Paul A Grimsrud, Matthew D Hirschey

NPJ Metab Health Dis· November 2025

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Fatty acid desaturases link cell metabolism pathways to promote proliferation of Epstein-Barr virus-infected B cells.
Emmanuela N Bonglack, Kaeden K Hill, Ashley P Barry, Alexandria Bartlett, Pol Castellano-Escuder, Matthew D Hirschey

PLoS Pathog· May 2025

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SIRT4 Controls Macrophage Function and Wound Healing through Control of Protein Itaconylation in Mice.
Kristin A Anderson, Beverly deSouza, Pol Castellano-Escuder, Zhihong Lin, Olga R Ilkayeva, Matthew D Hirschey

bioRxiv· May 2025

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Pathway Coessentiality Mapping Reveals Complex II is Required for Purine Biosynthesis in Acute Myeloid Leukemia.
Amy E Stewart, Derek K Zachman, Pol Castellano-Escuder, Lois M Kelly, Ben Zolyomi, Matthew D Hirschey

bioRxiv· March 2025

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Cysteine -acetylation is a post-translational modification involved in metabolic regulation.
E Keith Keenan, Akshay Bareja, Yannie Lam, Paul A Grimsrud, Matthew D Hirschey

bioRxiv· May 2024

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Optical imaging reveals chemotherapy-induced metabolic reprogramming of residual disease and recurrence.
Enakshi D Sunassee, Riley J Deutsch, Victoria W D'Agostino, Pol Castellano-Escuder, Elizabeth A Siebeneck, Matthew D Hirschey

Sci Adv· April 2024

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NAD metabolism modulates inflammation and mitochondria function in diabetic kidney disease.
Komuraiah Myakala, Xiaoxin X Wang, Nataliia V Shults, Ewa Krawczyk, Bryce A Jones, Matthew D Hirschey

J Biol Chem· August 2023

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In vivo metabolic imaging identifies lipid vulnerability in a preclinical model of Her2+/Neu breast cancer residual disease and recurrence.
Megan C Madonna, Joy E Duer, Brock J McKinney, Enakshi D Sunassee, Brian T Crouch, Matthew D Hirschey

NPJ Breast Cancer· September 2022

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Statin therapy inhibits fatty acid synthase via dynamic protein modifications.
Alec G Trub, Gregory R Wagner, Kristin A Anderson, Scott B Crown, Guo-Fang Zhang, Matthew D Hirschey

Nat Commun· May 2022

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Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice.
Dhaval P Bhatt, C Allie Mills, Kristin A Anderson, Bárbara J Henriques, Tânia G Lucas, Matthew D Hirschey

J Biol Chem· April 2022

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A cell-nonautonomous mechanism of yeast chronological aging regulated by caloric restriction and one-carbon metabolism.
Elisa Enriquez-Hesles, Daniel L Smith, Nazif Maqani, Margaret B Wierman, Matthew D Sutcliffe, Matthew D Hirschey

J Biol Chem· August 2021

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Early-life mitochondrial DNA damage results in lifelong deficits in energy production mediated by redox signaling in Caenorhabditis elegans.
Kathleen A Hershberger, John P Rooney, Elena A Turner, Lauren J Donoghue, Rakesh Bodhicharla, Matthew D Hirschey

Redox Biol· July 2021

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Discovering the landscape of protein modifications.
E Keith Keenan, Derek K Zachman, Matthew D Hirschey

Mol Cell· May 2021

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Sirtuin 5 Is Regulated by the SCF Ubiquitin Ligase and Is Involved in Cell Cycle Control.
Christine A Mills, Xianxi Wang, Dhaval P Bhatt, Paul A Grimsrud, Jacob Peter Matson, Matthew D Hirschey

Mol Cell Biol· January 2021

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Multiple metabolic changes mediate the response of Caenorhabditis elegans to the complex I inhibitor rotenone.
Claudia P Gonzalez-Hunt, Anthony L Luz, Ian T Ryde, Elena A Turner, Olga R Ilkayeva, Matthew D Hirschey

Toxicology· January 2021

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In Vivo Optical Metabolic Imaging of Long-Chain Fatty Acid Uptake in Orthotopic Models of Triple-Negative Breast Cancer.
Megan C Madonna, Joy E Duer, Joyce V Lee, Jeremy Williams, Baris Avsaroglu, Matthew D Hirschey

Cancers (Basel)· January 2021

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β-Cell-specific ablation of sirtuin 4 does not affect nutrient-stimulated insulin secretion in mice.
Frank K Huynh, Brett S Peterson, Kristin A Anderson, Zhihong Lin, Aeowynn J Coakley, Matthew D Hirschey

Am J Physiol Endocrinol Metab· October 2020

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NRF2 activation promotes the recurrence of dormant tumour cells through regulation of redox and nucleotide metabolism.
Douglas B Fox, Nina Marie G Garcia, Brock J McKinney, Ryan Lupo, Laura C Noteware, Matthew D Hirschey

Nat Metab· April 2020

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Investigating RNA expression profiles altered by nicotinamide mononucleotide therapy in a chronic model of alcoholic liver disease.
Mohammed A Assiri, Hadi R Ali, John O Marentette, Youngho Yun, Juan Liu, Matthew D Hirschey

Hum Genomics· December 2019

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SIRT6 Promotes Hepatic Beta-Oxidation via Activation of PPARα.
Shoshana Naiman, Frank K Huynh, Reuven Gil, Yair Glick, Yael Shahar, Matthew D Hirschey

Cell Rep· December 2019

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Loss of BCAA Catabolism during Carcinogenesis Enhances mTORC1 Activity and Promotes Tumor Development and Progression.
Russell E Ericksen, Siew Lan Lim, Eoin McDonnell, Wai Ho Shuen, Maya Vadiveloo, Matthew D Hirschey

Cell Metab· May 2019

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Quantifying Competition among Mitochondrial Protein Acylation Events Induced by Ethanol Metabolism.
Hadi R Ali, Mohammed A Assiri, Peter S Harris, Cole R Michel, Youngho Yun, Matthew D Hirschey

J Proteome Res· April 2019

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Cellular energetics and mitochondrial uncoupling in canine aging.
Justin W Nicholatos, Timothy M Robinette, Saurabh V P Tata, Jennifer D Yordy, Adam B Francisco, Matthew D Hirschey

Geroscience· April 2019

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