Publications by authors named "Matthew D Perry"

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A range of voltage-clamp protocol designs for rapid capture of hERG kinetics.
Chon Lok Lei, Dominic J Whittaker, Monique J Windley, Matthew D Perry, Adam P Hill

Wellcome Open Res· July 2025

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Action Potential Morphology Accurately Predicts Proarrhythmic Risk for Drugs With Potential to Prolong Cardiac Repolarization.
William Lee, Ben Ng, Melissa M Mangala, Matthew D Perry, Rajesh N Subbiah

Circ Arrhythm Electrophysiol· July 2023

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Development of a robust induced pluripotent stem cell atrial cardiomyocyte differentiation protocol to model atrial arrhythmia.
Jordan Thorpe, Matthew D Perry, Osvaldo Contreras, Emily Hurley, George Parker

Stem Cell Res Ther· July 2023

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Pathophysiological metabolic changes associated with disease modify the proarrhythmic risk profile of drugs with potential to prolong repolarisation.
Clifford TeBay, Jeffrey R McArthur, Melissa Mangala, Nicholas Kerr, Stewart Heitmann, Matthew D Perry

Br J Pharmacol· June 2022

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Co-expression of calcium and hERG potassium channels reduces the incidence of proarrhythmic events.
Sara Ballouz, Melissa M Mangala, Matthew D Perry, Stewart Heitmann, Jesse A Gillis

Cardiovasc Res· August 2021

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Heterozygous variant phenotyping using Flp-In HEK293 and high-throughput automated patch clamp electrophysiology.
Chai-Ann Ng, Jessica Farr, Paul Young, Monique J Windley, Matthew D Perry

Biol Methods Protoc· March 2021

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Pharmacological activation of IKr in models of long QT Type 2 risks overcorrection of repolarization.
Matthew D Perry, Chai-Ann Ng, Melissa M Mangala, Timothy Y M Ng, Adam D Hines

Cardiovasc Res· July 2020

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High-throughput phenotyping of heteromeric human ether-à-go-go-related gene potassium channel variants can discriminate pathogenic from rare benign variants.
Chai-Ann Ng, Matthew D Perry, Whitney Liang, Nicola J Smith, Brian Foo

Heart Rhythm· March 2020

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Protocol-Dependent Differences in IC Values Measured in Human Ether-Á-Go-Go-Related Gene Assays Occur in a Predictable Way and Can Be Used to Quantify State Preference of Drug Binding.
William Lee, Monique J Windley, Matthew D Perry, Jamie I Vandenberg, Adam P Hill

Mol Pharmacol· May 2019

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Recent advances in understanding and prevention of sudden cardiac death.
Jamie I Vandenberg, Matthew D Perry, Adam P Hill

F1000Res· August 2017

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The S1 helix critically regulates the finely tuned gating of Kv11.1 channels.
Kevin Phan, Chai Ann Ng, Erikka David, Dmitry Shishmarev, Philip W Kuchel, Matthew D Perry

J Biol Chem· May 2017

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Computational cardiology and risk stratification for sudden cardiac death: one of the grand challenges for cardiology in the 21st century.
Adam P Hill, Matthew D Perry, Najah Abi-Gerges, Jean-Philippe Couderc, Bernard Fermini

J Physiol· December 2016

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TECRL: connecting sequence to consequence for a new sudden cardiac death gene.
Matthew D Perry, Jamie I Vandenberg

EMBO Mol Med· December 2016

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Convergence of models of human ventricular myocyte electrophysiology after global optimization to recapitulate clinical long QT phenotypes.
Stefan A Mann, Mohammad Imtiaz, Annika Winbo, Annika Rydberg, Matthew D Perry

J Mol Cell Cardiol· November 2016

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Segmental differences in upregulated apical potassium channels in mammalian colon during potassium adaptation.
Matthew D Perry, Vazhaikkurichi M Rajendran, Kenneth A MacLennan, Geoffrey I Sandle

Am J Physiol Gastrointest Liver Physiol· November 2016

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Tyrosine Residues from the S4-S5 Linker of Kv11.1 Channels Are Critical for Slow Deactivation.
Chai-Ann Ng, Andrée E Gravel, Matthew D Perry, Alexandre A Arnold, Isabelle Marcotte

J Biol Chem· August 2016

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Rescue of protein expression defects may not be enough to abolish the pro-arrhythmic phenotype of long QT type 2 mutations.
Matthew D Perry, Chai Ann Ng, Kevin Phan, Erikka David, Kieran Steer

J Physiol· July 2016

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Steady-state modulation of voltage-gated K+ channels in rat arterial smooth muscle by cyclic AMP-dependent protein kinase and protein phosphatase 2B.
Jennifer L Brignell, Matthew D Perry, Carl P Nelson, Jonathon M Willets, R A John Challiss

PLoS One· February 2016

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Getting to the heart of hERG K(+) channel gating.
Matthew D Perry, Chai-Ann Ng, Stefan A Mann, Arash Sadrieh, Mohammad Imtiaz

J Physiol· June 2015

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Can many subunits make light work of ion channel inactivation?
Jamie I Vandenberg, Matthew D Perry

J Physiol· October 2014

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Multiple interactions between cytoplasmic domains regulate slow deactivation of Kv11.1 channels.
Chai Ann Ng, Kevin Phan, Adam P Hill, Jamie I Vandenberg, Matthew D Perry

J Biol Chem· September 2014

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Multiscale cardiac modelling reveals the origins of notched T waves in long QT syndrome type 2.
Arash Sadrieh, Luke Domanski, Joe Pitt-Francis, Stefan A Mann, Emily C Hodkinson, Matthew D Perry

Nat Commun· September 2014

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C-terminal β9-strand of the cyclic nucleotide-binding homology domain stabilizes activated states of Kv11.1 channels.
Chai Ann Ng, Ying Ke, Matthew D Perry, Peter S Tan, Adam P Hill

PLoS One· August 2014

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Role of the cytoplasmic N-terminal Cap and Per-Arnt-Sim (PAS) domain in trafficking and stabilization of Kv11.1 channels.
Ying Ke, Mark J Hunter, Chai Ann Ng, Matthew D Perry, Jamie I Vandenberg

J Biol Chem· May 2014

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Hydrophobic interactions between the voltage sensor and pore mediate inactivation in Kv11.1 channels.
Matthew D Perry, Sophia Wong, Chai Ann Ng, Jamie I Vandenberg

J Gen Physiol· September 2013

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