Publications by authors named "Matthew D Troutman"

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High-Throughput Detection and Quantitation of Metal Contamination with Acoustic Ejection Mass Spectrometry.
Alandra Quinn, Kenneth J Dirico, Simon Berritt, Thomas R Covey, Jamie Tourville, Matthew D Troutman

J Am Soc Mass Spectrom· August 2025

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High-Throughput Compound Quality Assessment with High-Mass-Resolution Acoustic Ejection Mass Spectrometry: An Automatic Data Processing Toolkit.
Alandra Quinn, Gordana Ivosev, Jefferson Chin, Robert Mongillo, Cristiano Veiga, Matthew D Troutman

Anal Chem· May 2024

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Chemical tools for the Gid4 subunit of the human E3 ligase C-terminal to LisH (CTLH) degradation complex.
Aliakbar Khalili Yazdi, Sumera Perveen, Cheng Dong, Xiaosheng Song, Aiping Dong, Matthew D Troutman

RSC Med Chem· March 2024

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Novel Multiplexed High Throughput Screening of Selective Inhibitors for Drug-Metabolizing Enzymes Using Human Hepatocytes.
Jianhua Liu, Daria Vernikovskaya, Gary Bora, Anthony Carlo, Woodrow Burchett, Matthew D Troutman

AAPS J· March 2024

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Acoustic Ejection Mass Spectrometry for High-Throughput Analysis.
Hui Zhang, Chang Liu, Wenyi Hua, Lucien P Ghislain, Jianhua Liu, Matthew D Troutman

Anal Chem· August 2021

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A Comparison of Two Stability Proteomics Methods for Drug Target Identification in OnePot 2D Format.
Yingrong Xu, Graham M West, Mario Abdelmessih, Matthew D Troutman, Robert A Everley

ACS Chem Biol· August 2021

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Ultra-High-Throughput Acoustic Droplet Ejection-Open Port Interface-Mass Spectrometry for Parallel Medicinal Chemistry.
Kenneth J DiRico, Wenyi Hua, Chang Liu, Joseph W Tucker, Anokha S Ratnayake, Matthew D Troutman

ACS Med Chem Lett· June 2020

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In Vitro-In Vivo Extrapolation of Key Transporter Activity at the Blood-Brain Barrier.
Patrick E Trapa, Matthew D Troutman, Thomas Y Lau, Travis T Wager, Tristan S Maurer

Drug Metab Dispos· April 2019

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Aldehyde oxidase 1 (AOX1) in human liver cytosols: quantitative characterization of AOX1 expression level and activity relationship.
Cexiong Fu, Li Di, Xiaogang Han, Cathy Soderstrom, Mark Snyder, Matthew D Troutman

Drug Metab Dispos· October 2013

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Mechanistic insights from comparing intrinsic clearance values between human liver microsomes and hepatocytes to guide drug design.
Li Di, Christopher Keefer, Dennis O Scott, Timothy J Strelevitz, George Chang, Matthew D Troutman

Eur J Med Chem· November 2012

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Development of a new permeability assay using low-efflux MDCKII cells.
Li Di, Carrie Whitney-Pickett, John P Umland, Hui Zhang, Xun Zhang, Matthew D Troutman

J Pharm Sci· November 2011

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Species independence in brain tissue binding using brain homogenates.
Li Di, John P Umland, George Chang, Youping Huang, Zhen Lin, Matthew D Troutman

Drug Metab Dispos· July 2011

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Defining desirable central nervous system drug space through the alignment of molecular properties, in vitro ADME, and safety attributes.
Travis T Wager, Ramalakshmi Y Chandrasekaran, Xinjun Hou, Matthew D Troutman, Patrick R Verhoest

ACS Chem Neurosci· June 2010

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Refining the in vitro and in vivo critical parameters for P-glycoprotein, [I]/IC50 and [I2]/IC50, that allow for the exclusion of drug candidates from clinical digoxin interaction studies.
Jack A Cook, Bo Feng, Katherine S Fenner, Sarah Kempshall, Ray Liu, Matthew D Troutman

Mol Pharm· April 2010

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Physicochemical space for optimum oral bioavailability: contribution of human intestinal absorption and first-pass elimination.
Manthena V S Varma, R Scott Obach, Charles Rotter, Howard R Miller, George Chang, Matthew D Troutman

J Med Chem· February 2010

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N-(3,4-dimethoxyphenethyl)-4-(6,7-dimethoxy-3,4-dihydroisoquinolin-2[1H]-yl)-6,7-dimethoxyquinazolin-2-amine (CP-100,356) as a "chemical knock-out equivalent" to assess the impact of efflux transporters on oral drug absorption in the rat.
Amit S Kalgutkar, Kosea S Frederick, Jonathan Chupka, Bo Feng, Sarah Kempshall, Matthew D Troutman

J Pharm Sci· December 2009

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Physicochemical determinants of human renal clearance.
Manthena V S Varma, Bo Feng, R Scott Obach, Matthew D Troutman, Jonathan Chupka

J Med Chem· August 2009

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The effect of breast cancer resistance protein and P-glycoprotein on the brain penetration of flavopiridol, imatinib mesylate (Gleevec), prazosin, and 2-methoxy-3-(4-(2-(5-methyl-2-phenyloxazol-4-yl)ethoxy)phenyl)propanoic acid (PF-407288) in mice.
Lin Zhou, Kari Schmidt, Frederick R Nelson, Veronica Zelesky, Matthew D Troutman

Drug Metab Dispos· May 2009

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In silico modeling of nonspecific binding to human liver microsomes.
Hua Gao, Lili Yao, Heather W Mathieu, Ying Zhang, Tristan S Maurer, Matthew D Troutman

Drug Metab Dispos· October 2008

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In vitro P-glycoprotein assays to predict the in vivo interactions of P-glycoprotein with drugs in the central nervous system.
Bo Feng, Jessica B Mills, Ralph E Davidson, Rouchelle J Mireles, John S Janiszewski, Matthew D Troutman

Drug Metab Dispos· February 2008

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Fluorescently labeled analogues of dofetilide as high-affinity fluorescence polarization ligands for the human ether-a-go-go-related gene (hERG) channel.
David H Singleton, Helen Boyd, Jill V Steidl-Nichols, Matt Deacon, Marcel J de Groot, Matthew D Troutman

J Med Chem· June 2007

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Rhodamine 123 requires carrier-mediated influx for its activity as a P-glycoprotein substrate in Caco-2 cells.
Matthew D Troutman, Dhiren R Thakker

Pharm Res· August 2003

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Efflux ratio cannot assess P-glycoprotein-mediated attenuation of absorptive transport: asymmetric effect of P-glycoprotein on absorptive and secretory transport across Caco-2 cell monolayers.
Matthew D Troutman, Dhiren R Thakker

Pharm Res· August 2003

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Novel experimental parameters to quantify the modulation of absorptive and secretory transport of compounds by P-glycoprotein in cell culture models of intestinal epithelium.
Matthew D Troutman, Dhiren R Thakker

Pharm Res· August 2003

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Phospholipase C-gamma modulates epithelial tight junction permeability through hyperphosphorylation of tight junction proteins.
Peter D Ward, Ryan R Klein, Matthew D Troutman, Shaleish Desai, Dhiren R Thakker

J Biol Chem· September 2002

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