Publications by authors named "Matthew Freedman"

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Author Correction: Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus.
Kate Lawrenson, Siddhartha Kar, Karen McCue, Karoline Kuchenbaeker, Kyriaki Michailidou, Matthew L Freedman

Nat Commun· September 2025

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Detection and monitoring of translocation renal cell carcinoma via plasma cell-free epigenomic profiling.
Simon Garinet, Karl Semaan, Jiao Li, Ananthan Sadagopan, John Canniff, Matthew L Freedman

bioRxiv· September 2025

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Targeting AXL can effectively overcome c-Met-induced therapeutic resistance in renal cancer and promote tumor cell death through increased oxidative stress.
Akash Sabarwal, Marc Machaalani, Laxminarayan Rawat, Johannes Wedel, Saba Tabasum, Matthew L Freedman

Cancer Lett· August 2025

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EZH2-TTP-mTORC1 Axis Drives Phenotypic Plasticity and Therapeutic Vulnerability in Lethal Prostate Cancer.
Beatriz German, Katherine L Morel, Teia Noel, Nadia Boufaied, Deborah L Burkhart, Matthew L Freedman

bioRxiv· August 2025

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EZH2-TTP-mTORC1 Axis Drives Phenotypic Plasticity and Therapeutic Vulnerability in Lethal Prostate Cancer.
Beatriz German, Katherine L Morel, Teia Noel, Nadia Boufaied, Deborah L Burkhart, Matthew L Freedman

Res Sq· August 2025

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Epigenetic profiling identifies markers of endocrine resistance and therapeutic options for metastatic castration-resistant prostate cancer.
Tesa M Severson, Emma Minnee, Yanyun Zhu, Karianne Schuurman, Holly M Nguyen, Matthew L Freedman

Cell Rep Med· July 2025

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Plasma epigenomic profiling reveals treatment-emergent squamous transformation in prostate cancer.
Karl Semaan, Rashad Nawfal, John Canniff, Hunter Savignano, Ji-Heui Seo, Matthew L Freedman

NPJ Precis Oncol· July 2025

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EED Maintains the Small Cell Lung Cancer Neuroendocrine Phenotype and Drives Lung Cancer Histological Transformation.
Yixiang Li, Yasmin N Laimon, Hyeonseo Cho, Marina Vivero, Gabriel Roberti De Oliveira, Matthew L Freedman

bioRxiv· July 2025

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KDM4C inhibition blocks tumor growth in basal breast cancer by promoting cathepsin L-mediated histone H3 cleavage.
Zheqi Li, Guillermo Peluffo, Laura E Stevens, Xintao Qiu, Marco Seehawer, Matthew L Freedman

Nat Genet· June 2025

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The Germline and Somatic Origins of Prostate Cancer Heterogeneity.
Takafumi N Yamaguchi, Kathleen E Houlahan, Helen Zhu, Natalie Kurganovs, Julie Livingstone, Matthew L Freedman

Cancer Discov· May 2025

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Increased nuclear factor I-mediated chromatin access drives transition to androgen receptor splice variant dependence in prostate cancer.
Larysa Poluben, Mannan Nouri, Jiaqian Liang, Shaoyong Chen, Andreas Varkaris, Matthew L Freedman

Cell Rep· January 2025

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Decoding the epigenetics and chromatin loop dynamics of androgen receptor-mediated transcription.
Umut Berkay Altıntaş, Ji-Heui Seo, Claudia Giambartolomei, Dogancan Ozturan, Brad J Fortunato, Matthew L Freedman

Nat Commun· November 2024

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Detecting Small Cell Transformation in Patients with Advanced EGFR Mutant Lung Adenocarcinoma through Epigenomic cfDNA Profiling.
Talal El Zarif, Catherine B Meador, Xintao Qiu, Ji-Heui Seo, Matthew P Davidsohn, Matthew L Freedman

Clin Cancer Res· September 2024

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MYBL2 Drives Prostate Cancer Plasticity: Inhibiting Its Transcriptional Target CDK2 for RB1-Deficient Neuroendocrine Prostate Cancer.
Beatriz German, Sarah A Alaiwi, Kun-Lin Ho, Jagpreet S Nanda, Marcos A Fonseca, Matthew L Freedman

Cancer Res Commun· September 2024

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Frequent CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression.
Miklos Diossy, Viktoria Tisza, Hua Li, Pranshu Sahgal, Jia Zhou, Matthew L Freedman

NPJ Precis Oncol· September 2024

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Plasma Kidney Injury Molecule-1 for Preoperative Prediction of Renal Cell Carcinoma Versus Benign Renal Masses, and Association With Clinical Outcomes.
Wenxin Xu, Valerie Gaborieau, Samuel M Niman, Anush Mukeria, Xiaowen Liu, Matthew L Freedman

J Clin Oncol· August 2024

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Increased chromatin accessibility mediated by nuclear factor I drives transition to androgen receptor splice variant dependence in castration-resistant prostate cancer.
Larysa Poluben, Mannan Nouri, Jiaqian Liang, Andreas Varkaris, Betul Ersoy-Fazlioglu, Matthew L Freedman

bioRxiv· June 2024

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Integrative multi-omics analyses to identify the genetic and functional mechanisms underlying ovarian cancer risk regions.
Eileen O Dareng, Simon G Coetzee, Jonathan P Tyrer, Pei-Chen Peng, Will Rosenow, Matthew L Freedman

Am J Hum Genet· June 2024

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Epigenomic signatures of sarcomatoid differentiation to guide the treatment of renal cell carcinoma.
Talal El Zarif, Karl Semaan, Marc Eid, Ji-Heui Seo, Simon Garinet, Matthew L Freedman

Cell Rep· June 2024

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Multi-ancestry genome-wide association study of kidney cancer identifies 63 susceptibility regions.
Mark P Purdue, Diptavo Dutta, Mitchell J Machiela, Bryan R Gorman, Timothy Winter, Matthew L Freedman, Neal D Freedman

Nat Genet· May 2024

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Increased frequency of CHD1 deletions in prostate cancers of African American men is associated with rapid disease progression without inducing homologous recombination deficiency.
Zoltan Szallasi, Miklos Diossy, Viktoria Tisza, Hua Li, Pranshu Sahgal, Matthew Freedman

Res Sq· April 2024

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Author Correction: Liquid biopsy epigenomic profiling for cancer subtyping.
Sylvan C Baca, Ji-Heui Seo, Matthew P Davidsohn, Brad Fortunato, Karl Semaan, Matthew L Freedman

Nat Med· March 2024

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Decoding the Epigenetics and Chromatin Loop Dynamics of Androgen Receptor-Mediated Transcription.
Nathan Lack, Umut Berkay Altintas, Ji-Heu Seo, Claudia Giambartolomei, Dogancan Ozturan, Matthew Freedman

Res Sq· February 2024

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The PENGUIN approach to reconstruct protein interactions at enhancer-promoter regions and its application to prostate cancer.
Alexandros Armaos, François Serra, Iker Núñez-Carpintero, Ji-Heui Seo, Sylvan C Baca, Matthew L Freedman

Nat Commun· December 2023

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Liquid biopsy epigenomic profiling for cancer subtyping.
Sylvan C Baca, Ji-Heui Seo, Matthew P Davidsohn, Brad Fortunato, Karl Semaan, Matthew L Freedman

Nat Med· November 2023

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