Publications by authors named "Matthew Gegg"

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The influence of the glymphatic system on α-synuclein propagation: the role of aquaporin-4.
Douglas M Lopes, Sophie K Llewellyn, Sheila E Bury, Jiazheng Wang, Jack A Wells, Matthew E Gegg

Brain· December 2025

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Lysosomal TPC2 channels disrupt Ca2+ entry and dopaminergic function in models of LRRK2-Parkinson's disease.
Martina Gregori, Gustavo J S Pereira, Robert Allen, Nicholas West, Kai-Yin Chau, Matthew E Gegg

J Cell Biol· June 2025

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Elevated cholesterol in ATAD3 mutants is a compensatory mechanism that leads to membrane cholesterol aggregation.
Mikel Muñoz-Oreja, Abigail Sandoval, Ove Bruland, Diego Perez-Rodriguez, Uxoa Fernandez-Pelayo, Matthew E Gegg

Brain· May 2024

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The importance of being connected: membrane contact sites and Parkinson's disease.
Matthew E Gegg

Neural Regen Res· October 2023

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α-Synuclein expression in response to bacterial ligands and metabolites in gut enteroendocrine cells: an proof of concept study.
Michael J Hurley, Elisa Menozzi, Sofia Koletsi, Rachel Bates, Matthew E Gegg

Brain Commun· October 2023

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Unexpected phenotypic and molecular changes of combined glucocerebrosidase and acid sphingomyelinase deficiency.
Marcus Keatinge, Matthew E Gegg, Lisa Watson, Heather Mortiboys, Nan Li

Dis Model Mech· June 2023

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The GBA variant E326K is associated with alpha-synuclein aggregation and lipid droplet accumulation in human cell lines.
Laura J Smith, Magdalena M Bolsinger, Kai-Yin Chau, Matthew E Gegg, Anthony H V Schapira

Hum Mol Genet· February 2023

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Lysosomal-endolysomal dysfunction and neurodegenerative diseases.
Matthew E Gegg, Anthony H V Schapira

Neurobiol Dis· October 2022

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Ambroxol reverses tau and α-synuclein accumulation in a cholinergic N370S GBA1 mutation model.
Shi Yu Yang, Jan-Willem Taanman, Matthew Gegg, Anthony H V Schapira

Hum Mol Genet· July 2022

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Glucocerebrosidase-associated Parkinson disease: Pathogenic mechanisms and potential drug treatments.
Matthew E Gegg, Elisa Menozzi, Anthony H V Schapira

Neurobiol Dis· May 2022

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Glucocerebrosidase deficiency promotes release of α-synuclein fibrils from cultured neurons.
Matthew E Gegg, Guglielmo Verona, Anthony H V Schapira

Hum Mol Genet· June 2020

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Glucocerebrosidase activity, cathepsin D and monomeric α-synuclein interactions in a stem cell derived neuronal model of a PD associated GBA1 mutation.
Shi-Yu Yang, Matthew Gegg, David Chau, Anthony Schapira

Neurobiol Dis· February 2020

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mutation promotes early mitochondrial dysfunction in 3D neurosphere models.
Constanza Morén, Diana Luz Juárez-Flores, Kai-Yin Chau, Matthew Gegg, Glòria Garrabou

Aging (Albany NY)· November 2019

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Ablation of the pro-inflammatory master regulator miR-155 does not mitigate neuroinflammation or neurodegeneration in a vertebrate model of Gaucher's disease.
Lisa Watson, Marcus Keatinge, Matthew Gegg, Qing Bai, M Cosmin Sandulescu

Neurobiol Dis· July 2019

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The role of glucocerebrosidase in Parkinson disease pathogenesis.
Matthew E Gegg, Anthony H V Schapira

FEBS J· October 2018

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The role of DJ-1 complexes and catecholamine metabolism: relevance for familial and idiopathic Parkinson's disease.
Dominik Piston, Matthew E Gegg

Neural Regen Res· May 2018

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DJ-1 is a redox sensitive adapter protein for high molecular weight complexes involved in regulation of catecholamine homeostasis.
Dominik Piston, Lydia Alvarez-Erviti, Vikas Bansal, Daniela Gargano, Zhi Yao, Matthew E Gegg

Hum Mol Genet· February 2018

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DJ-1 is a redox sensitive adapter protein for high molecular weight complexes involved in regulation of catecholamine homeostasis.
Dominik Piston, Lydia Alvarez-Erviti, Vikas Bansal, Daniela Gargano, Zhi Yao, Matthew E Gegg

Hum Mol Genet· October 2017

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A Drosophila Model of Neuronopathic Gaucher Disease Demonstrates Lysosomal-Autophagic Defects and Altered mTOR Signalling and Is Functionally Rescued by Rapamycin.
Kerri J Kinghorn, Sebastian Grönke, Jorge Iván Castillo-Quan, Nathaniel S Woodling, Li Li, Matthew Gegg

J Neurosci· November 2016

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Autophagic lysosome reformation dysfunction in glucocerebrosidase deficient cells: relevance to Parkinson disease.
Joana Magalhaes, Matthew E Gegg, Anna Migdalska-Richards, Mary K Doherty, Phillip D Whitfield

Hum Mol Genet· August 2016

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Parkinson disease-linked GBA mutation effects reversed by molecular chaperones in human cell and fly models.
Alvaro Sanchez-Martinez, Michelle Beavan, Matthew E Gegg, Kai-Yin Chau, Alexander J Whitworth

Sci Rep· August 2016

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Mitochondria: Key Organelle in Parkinson's Disease.
Rubén Gómez-Sánchez, José M Bravo-San Pedro, Matthew E Gegg, Rosa A González-Polo, José M Fuentes

Parkinsons Dis· August 2016

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Mitochondrial dysfunction associated with glucocerebrosidase deficiency.
Matthew E Gegg, Anthony H V Schapira

Neurobiol Dis· June 2016

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Mitochondrial and lysosomal biogenesis are activated following PINK1/parkin-mediated mitophagy.
Davor Ivankovic, Kai-Yin Chau, Anthony H V Schapira, Matthew E Gegg

J Neurochem· January 2016

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Endoplasmic reticulum and lysosomal Ca²⁺ stores are remodelled in GBA1-linked Parkinson disease patient fibroblasts.
Bethan S Kilpatrick, Joana Magalhaes, Michelle S Beavan, Alisdair McNeill, Matthew E Gegg

Cell Calcium· January 2016

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