Publications by authors named "Matthew Groves"

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1-Deoxy-D-xylulose 5-phosphate synthase: structural perspectives on an essential enzyme in isoprenoid biosynthesis.
Victor O Gawriljuk, Rick Oerlemans, Eswar R Reddem, Robin M Gierse, Anna K H Hirsch, Matthew R Groves

J Struct Biol· September 2025

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Exploring Aspartate Transcarbamoylase: A Promising Broad-Spectrum Target for Drug Development.
Siyao Chen, Queenie Mondile, XiaoChen Du, Chao Wang, Mayur Mukim, Matthew R Groves

Chembiochem· April 2025

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New homocysteine consumption assay for high-throughput screening of human cystathionine-β-synthase.
Dalibor Nakládal, Rick Oerlemans, Miroslava Molitorisová, Nikola Chomaničová, Gabriel Zorkócy, Matthew R Groves

SLAS Discov· April 2025

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Apo structure of Mycobacterium tuberculosis 1-deoxy-d-xylulose 5-phosphate synthase DXPS: Dynamics and implications for inhibitor design.
Victor O Gawriljuk, Alaa Alhayek, Anna K H Hirsch, Matthew R Groves

Biochem Biophys Res Commun· February 2025

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Cryo-EM structure of 1-deoxy-D-xylulose 5-phosphate synthase DXPS from Plasmodium falciparum reveals a distinct N-terminal domain.
Victor O Gawriljuk, Andre S Godoy, Rick Oerlemans, Luise A T Welker, Anna K H Hirsch, Matthew R Groves

Nat Commun· August 2024

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Small-Molecule Allosteric Inhibitors of Human Aspartate Transcarbamoylase Suppress Proliferation of Bone Osteosarcoma Epithelial Cells.
Chao Wang, Bidong Zhang, Yingying Cong, Xiaochen Du, Siyao Chen, Matthew R Groves

ChemMedChem· July 2024

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Engineering a Plant Polyketide Synthase for the Biosynthesis of Methylated Flavonoids.
Bo Peng, Lili Zhang, Siqi He, Rick Oerlemans, Wim J Quax, Matthew R Groves

J Agric Food Chem· January 2024

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Thiosulfate sulfurtransferase deficiency promotes oxidative distress and aberrant NRF2 function in the brain.
Yang Luo, Laurent Chatre, Shaden Melhem, Zayana M Al-Dahmani, Natalie Z M Homer, Matthew R Groves

Redox Biol· December 2023

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A comprehensive overview of the heterogeneity of EGFR exon 20 variants in NSCLC and (pre)clinical activity to currently available treatments.
Fenneke Zwierenga, Bianca A M H van Veggel, Anke van den Berg, Harry J M Groen, Lili Zhang, Matthew R Groves

Cancer Treat Rev· November 2023

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Identification and characterization of a small molecule that activates thiosulfate sulfurtransferase and stimulates mitochondrial respiration.
Zeyana M Al-Dahmani, Mojgan Hadian, Angel J Ruiz-Moreno, Sabogal-Guaqueta Angelica Maria, Fernando A Batista, Matthew R Groves

Protein Sci· November 2023

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Correction: Isolation and molecular characterization of novel glucarpidases: Enzymes to improve the antibody directed enzyme pro-drug therapy for cancer treatment.
Fatma B Rashidi, Alanod D Al-Qahtani, Sara S Bashraheel, Shabnam Shaabani, Matthew R Groves

PLoS One· November 2023

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Inhibitors of Aspartate Transcarbamoylase Inhibit Mycobacterium tuberculosis Growth.
Xiaochen Du, Vidhisha Sonawane, Bidong Zhang, Chao Wang, Bram de Ruijter, Matthew R Groves

ChemMedChem· September 2023

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Structural Characterization and Extended Substrate Scope Analysis of Two Mg -Dependent O-Methyltransferases from Bacteria.
Nika Sokolova, Lili Zhang, Sadaf Deravi, Rick Oerlemans, Matthew R Groves

Chembiochem· May 2023

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Determination of Binding Sites on Trastuzumab and Pertuzumab to Selective Affimers Using Hydrogen-Deuterium Exchange Mass Spectrometry.
Oladapo Olaleye, Christian Graf, Baubek Spanov, Natalia Govorukhina, Matthew R Groves

J Am Soc Mass Spectrom· April 2023

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Discovery of Small-Molecule Allosteric Inhibitors of ATC as Antimalarials.
Chao Wang, Bidong Zhang, Arne Krüger, Xiaochen Du, Lidia Visser, Matthew R Groves

J Am Chem Soc· October 2022

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Multicomponent Macrocyclic IL-17a Modifier.
Eman Abdelraheem, Max Lubberink, Wenja Wang, Jingyao Li, Atilio Reyes Romero, Matthew Groves

ACS Med Chem Lett· September 2022

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Thiosulfate sulfurtransferase prevents hyperglycemic damage to the zebrafish pronephros in an experimental model for diabetes.
Zayana M Al-Dahmani, Xiaogang Li, Lucas M Wiggenhauser, Hannes Ott, Paul D Kruithof, Matthew R Groves

Sci Rep· July 2022

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First crystal structures of 1-deoxy-D-xylulose 5-phosphate synthase (DXPS) from Mycobacterium tuberculosis indicate a distinct mechanism of intermediate stabilization.
Robin M Gierse, Rick Oerlemans, Eswar R Reddem, Victor O Gawriljuk, Alaa Alhayek, Matthew R Groves

Sci Rep· May 2022

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Novel Highlight in Malarial Drug Discovery: Aspartate Transcarbamoylase.
Chao Wang, Arne Krüger, Xiaochen Du, Carsten Wrenger, Matthew R Groves

Front Cell Infect Microbiol· April 2022

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Feasibility of Follow-Up Studies and Reclassification in Spinocerebellar Ataxia Gene Variants of Unknown Significance.
Fatemeh Ghorbani, Mohamed Z Alimohamed, Juliana F Vilacha, Krista K Van Dijk, Jelkje De Boer-Bergsma, Matthew R Groves

Front Genet· March 2022

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Synthetic Peptides That Antagonize the Angiotensin-Converting Enzyme-2 (ACE-2) Interaction with SARS-CoV-2 Receptor Binding Spike Protein.
Afsaneh Sadremomtaz, Zayana M Al-Dahmani, Angel J Ruiz-Moreno, Alessandra Monti, Chao Wang, Matthew R Groves

J Med Chem· February 2022

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Design, synthesis and biological evaluation of 1,5-disubstituted α-amino tetrazole derivatives as non-covalent inflammasome-caspase-1 complex inhibitors with potential application against immune and inflammatory disorders.
Fausta Ulgheri, Pietro Spanu, Francesco Deligia, Giovanni Loriga, Maria Pia Fuggetta, Matthew Groves

Eur J Med Chem· February 2022

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Lipoic Acid Metabolism as a Potential Chemotherapeutic Target Against and .
Sun Liu Rei Yan, Felipe Wakasuqui, Xiaochen Du, Matthew R Groves, Carsten Wrenger

Front Chem· November 2021

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A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity.
Atilio Reyes Romero, Serjey Lunev, Grzegorz M Popowicz, Vito Calderone, Matteo Gentili, Matthew R Groves

Commun Biol· August 2021

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Pharmacological Rationale for Targeting IL-17 in Asthma.
Siti Farah Rahmawati, Maurice Te Velde, Huib A M Kerstjens, Alexander S S Dömling, Matthew Robert Groves

Front Allergy· August 2021

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