Publications by authors named "Matthew Labenski"

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Novel Corrector for Variants of SLC6A8: A Therapeutic Opportunity for Creatine Transporter Deficiency.
Lara N Gechijian, Giovanni Muncipinto, T Justin Rettenmaier, Matthew T Labenski, Victor Rusu

ACS Chem Biol· November 2024

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SLC6A19 inhibition facilitates urinary neutral amino acid excretion and lowers plasma phenylalanine.
Heike J Wobst, Andreu Viader, Giovanni Muncipinto, Ryan Hollibaugh, Daniel van Kalken, Matthew T Labenski

JCI Insight· November 2024

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A Probe-Free Occupancy Assay to Assess a Targeted Covalent Inhibitor of Receptor Tyrosine-Protein Kinase erbB-2.
Liang Xue, Daniel van Kalken, Erika M James, Giulia Giammo, Matthew T Labenski

ACS Pharmacol Transl Sci· August 2024

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SMaSh: A Streptavidin Mass Shift Assay for Rapidly Quantifying Target Occupancy by Irreversible Inhibitors.
Matthew T Labenski, Leslie A Bateman, Lukas T Voortman, Giulia Giammo, Susan Cantin

Biochemistry· October 2021

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Labeling Preferences of Diazirines with Protein Biomolecules.
Alexander V West, Giovanni Muncipinto, Hung-Yi Wu, Andrew C Huang, Matthew T Labenski

J Am Chem Soc· May 2021

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Transcriptional and post-translational modifications of B-Raf in quinol-thioether induced tuberous sclerosis renal cell carcinoma.
Jennifer D Cohen, Matthew Labenski, Nicholas J Mastrandrea, Ryan D Canatsey, Terrence J Monks

Mol Carcinog· August 2016

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S-adenosyl-l-methionine protection of acetaminophen mediated oxidative stress and identification of hepatic 4-hydroxynonenal protein adducts by mass spectrometry.
James Mike Brown, Christopher Kuhlman, Marcus V Terneus, Matthew T Labenski, Andre Benja Lamyaithong

Toxicol Appl Pharmacol· December 2014

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In vitro and in vivo characterization of irreversible mutant-selective EGFR inhibitors that are wild-type sparing.
Robert Tjin Tham Sjin, Kwangho Lee, Annette O Walter, Aleksandr Dubrovskiy, Michael Sheets, Matthew T Labenski

Mol Cancer Ther· June 2014

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Discovery of a mutant-selective covalent inhibitor of EGFR that overcomes T790M-mediated resistance in NSCLC.
Annette O Walter, Robert Tjin Tham Sjin, Henry J Haringsma, Kadoaki Ohashi, Jing Sun, Matthew Labenski

Cancer Discov· December 2013

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Inhibition of Btk with CC-292 provides early pharmacodynamic assessment of activity in mice and humans.
Erica K Evans, Richland Tester, Sharon Aslanian, Russell Karp, Michael Sheets, Matthew T Labenski

J Pharmacol Exp Ther· August 2013

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Metabolites of PPI-2458, a selective, irreversible inhibitor of methionine aminopeptidase-2: structure determination and in vivo activity.
Christopher C Arico-Muendel, Bruce Belanger, Dennis Benjamin, Heather S Blanchette, Teresa M Caiazzo, Matthew T Labenski

Drug Metab Dispos· April 2013

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Orally active fumagillin analogues: transformations of a reactive warhead in the gastric environment.
Christopher C Arico-Muendel, Heather Blanchette, Dennis R Benjamin, Teresa M Caiazzo, Paolo A Centrella, Matthew T Labenski

ACS Med Chem Lett· April 2013

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Discovery of a potent and isoform-selective targeted covalent inhibitor of the lipid kinase PI3Kα.
Mariana Nacht, Lixin Qiao, Michael P Sheets, Thia St Martin, Matthew Labenski

J Med Chem· February 2013

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The frequency of 1,4-benzoquinone-lysine adducts in cytochrome c correlate with defects in apoptosome activation.
Ashley A Fisher, Matthew T Labenski, Srinivas Malladi, John D Chapman, Shawn B Bratton

Toxicol Sci· July 2011

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Utilization of MALDI-TOF to determine chemical-protein adduct formation in vitro.
Ashley A Fisher, Matthew T Labenski, Terrence J Monks, Serrine S Lau

Methods Mol Biol· February 2011

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Utilization of LC-MS/MS analyses to identify site-specific chemical protein adducts in vitro.
Ashley A Fisher, Matthew T Labenski, Terrence J Monks, Serrine S Lau

Methods Mol Biol· February 2011

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One-dimensional western blotting coupled to LC-MS/MS analysis to identify chemical-adducted proteins in rat urine.
Matthew T Labenski, Ashley A Fisher, Terrence J Monks, Serrine S Lau

Methods Mol Biol· February 2011

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Identification of chemical-adducted proteins in urine by multi-dimensional protein identification technology (LC/LC-MS/MS).
Matthew T Labenski, Ashley A Fisher, Terrence J Monks, Serrine S Lau

Methods Mol Biol· February 2011

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Selective irreversible inhibition of a protease by targeting a noncatalytic cysteine.
Margit Hagel, Deqiang Niu, Thia St Martin, Michael P Sheets, Lixin Qiao, Matthew T Labenski

Nat Chem Biol· January 2011

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Carbamate analogues of fumagillin as potent, targeted inhibitors of methionine aminopeptidase-2.
Christopher C Arico-Muendel, Dennis R Benjamin, Teresa M Caiazzo, Paolo A Centrella, Brooke D Contonio, Matthew T Labenski

J Med Chem· December 2009

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Protein electrophile-binding motifs: lysine-rich proteins are preferential targets of quinones.
Matthew T Labenski, Ashley A Fisher, Herng-Hsiang Lo, Terrence J Monks, Serrine S Lau

Drug Metab Dispos· June 2009

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Quinone electrophiles selectively adduct "electrophile binding motifs" within cytochrome c.
Ashley A Fisher, Matthew T Labenski, Srinivas Malladi, Vijay Gokhale, Martina E Bowen

Biochemistry· October 2007

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Inhibition of melanoma tumor growth by a pharmacological inhibitor of MetAP-2, PPI-2458.
Gerhard Hannig, Douglas D Lazarus, Sylvie G Bernier, Russell M Karp, Jeanine Lorusso, Matthew T Labenski

Int J Oncol· April 2006

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A novel methionine aminopeptidase-2 inhibitor, PPI-2458, inhibits non-Hodgkin's lymphoma cell proliferation in vitro and in vivo.
Andrew C Cooper, Russell M Karp, Edward J Clark, Nazbeh R Taghizadeh, Jennifer G Hoyt, Matthew T Labenski

Clin Cancer Res· April 2006

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A methionine aminopeptidase-2 inhibitor, PPI-2458, for the treatment of rheumatoid arthritis.
Sylvie G Bernier, Douglas D Lazarus, Edward Clark, Beth Doyle, Matthew T Labenski

Proc Natl Acad Sci U S A· July 2004

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