Publications by authors named "Matthew Longley"

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Structure-specific roles for PolG2-DNA complexes in maintenance and replication of mitochondrial DNA.
Jessica L Wojtaszek, Kirsten E Hoff, Matthew J Longley, Parminder Kaur, Sara N Andres

Nucleic Acids Res· October 2023

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Mitochondrial DNA Enrichment for Sensitive Next-Generation Sequencing.
Shilan Wu, Matthew J Longley, Scott A Lujan, Thomas A Kunkel, William C Copeland

Methods Mol Biol· February 2023

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Method for the structural analysis of Twinkle mitochondrial DNA helicase by cryo-EM.
Amanda A Riccio, Jonathan Bouvette, Matthew J Longley, Juno M Krahn, Mario J Borgnia

Methods· September 2022

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Structural insight and characterization of human Twinkle helicase in mitochondrial disease.
Amanda A Riccio, Jonathan Bouvette, Lalith Perera, Matthew J Longley, Juno M Krahn

Proc Natl Acad Sci U S A· August 2022

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Using Atomic Force Microscopy to Study the Real Time Dynamics of DNA Unwinding by Mitochondrial Twinkle Helicase.
Parminder Kaur, Hai Pan, Matthew J Longley, William C Copeland, Hong Wang

Bio Protoc· September 2021

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Polymerase γ efficiently replicates through many natural template barriers but stalls at the HSP1 quadruplex.
Eric D Sullivan, Matthew J Longley, William C Copeland

J Biol Chem· December 2020

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Ultrasensitive deletion detection links mitochondrial DNA replication, disease, and aging.
Scott A Lujan, Matthew J Longley, Margaret H Humble, Christopher A Lavender, Adam Burkholder

Genome Biol· September 2020

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Single-molecule level structural dynamics of DNA unwinding by human mitochondrial Twinkle helicase.
Parminder Kaur, Matthew J Longley, Hai Pan, Wendy Wang, Preston Countryman

J Biol Chem· April 2020

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Mitochondrial single-stranded DNA binding protein novel de novo SSBP1 mutation in a child with single large-scale mtDNA deletion (SLSMD) clinically manifesting as Pearson, Kearns-Sayre, and Leigh syndromes.
Margaret A Gustafson, Elizabeth M McCormick, Lalith Perera, Matthew J Longley, Renkui Bai

PLoS One· March 2020

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Characterization of the human homozygous R182W POLG2 mutation in mitochondrial DNA depletion syndrome.
Kirsten E Hoff, Karen L DeBalsi, Maria J Sanchez-Quintero, Matthew J Longley, Michio Hirano

PLoS One· February 2019

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Single-molecule DREEM imaging reveals DNA wrapping around human mitochondrial single-stranded DNA binding protein.
Parminder Kaur, Matthew J Longley, Hai Pan, Hong Wang, William C Copeland

Nucleic Acids Res· November 2018

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The C-terminal tail of the NEIL1 DNA glycosylase interacts with the human mitochondrial single-stranded DNA binding protein.
Nidhi Sharma, Srinivas Chakravarthy, Matthew J Longley, William C Copeland, Aishwarya Prakash

DNA Repair (Amst)· May 2018

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DNA polymerase β: A missing link of the base excision repair machinery in mammalian mitochondria.
Rajendra Prasad, Melike Çağlayan, Da-Peng Dai, Cristina A Nadalutti, Ming-Lang Zhao, Matthew J Longley

DNA Repair (Amst)· December 2017

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Complementation of aprataxin deficiency by base excision repair enzymes in mitochondrial extracts.
Melike Çaglayan, Rajendra Prasad, Rachel Krasich, Matthew J Longley, Kei Kadoda

Nucleic Acids Res· September 2017

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Synergistic Effects of the T251I and P587L Mitochondrial DNA Polymerase γ Disease Mutations.
Karen L DeBalsi, Matthew J Longley, Kirsten E Hoff, William C Copeland

J Biol Chem· March 2017

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An open source device for operant licking in rats.
Matthew Longley, Ethan L Willis, Cindy X Tay, Hao Chen

PeerJ· February 2017

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Analysis of Translesion DNA Synthesis by the Mitochondrial DNA Polymerase γ.
William C Copeland, Rajesh Kasiviswanathan, Matthew J Longley

Methods Mol Biol· September 2016

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Mitochondrial genome maintenance in health and disease.
William C Copeland, Matthew J Longley

DNA Repair (Amst)· July 2014

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A p.R369G POLG2 mutation associated with adPEO and multiple mtDNA deletions causes decreased affinity between polymerase γ subunits.
Kate Craig, Matthew J Young, Emma L Blakely, Matthew J Longley, Douglass M Turnbull

Mitochondrion· March 2012

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Biochemical analysis of human POLG2 variants associated with mitochondrial disease.
Matthew J Young, Matthew J Longley, Fang-Yuan Li, Rajesh Kasiviswanathan, Lee-Jun Wong

Hum Mol Genet· August 2011

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Disease variants of the human mitochondrial DNA helicase encoded by C10orf2 differentially alter protein stability, nucleotide hydrolysis, and helicase activity.
Matthew J Longley, Margaret M Humble, Farida S Sharief, William C Copeland

J Biol Chem· September 2010

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Purification and functional characterization of human mitochondrial DNA polymerase gamma harboring disease mutations.
Rajesh Kasiviswanathan, Matthew J Longley, Matthew J Young, William C Copeland

Methods· August 2010

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Meeting report: Identification of biomarkers for early detection of mitochondrial dysfunction.
Daniel T Shaughnessy, Leroy Worth, Cindy P Lawler, Kimberly A McAllister, Matthew J Longley

Mitochondrion· August 2010

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Preparation of human mitochondrial single-stranded DNA-binding protein.
Matthew J Longley, Leslie A Smith, William C Copeland

Methods Mol Biol· October 2009

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Disease mutations in the human mitochondrial DNA polymerase thumb subdomain impart severe defects in mitochondrial DNA replication.
Rajesh Kasiviswanathan, Matthew J Longley, Sherine S L Chan, William C Copeland

J Biol Chem· July 2009

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