Publications by authors named "Matthew M Hamilton"

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Allosteric targeting of RIPK1: discovery of novel inhibitors parallel virtual screening and structure-guided optimization.
R S K Vijayan, Matthew M Hamilton, Dana E Pfaffinger, Fernando G Alvarez, Naphtali J Reyna

RSC Med Chem· September 2025

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Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.
Matthew M Hamilton, Faika Mseeh, Timothy J McAfoos, Paul G Leonard, Naphtali J Reyna

J Med Chem· August 2021

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Discovery of IPN60090, a Clinical Stage Selective Glutaminase-1 (GLS-1) Inhibitor with Excellent Pharmacokinetic and Physicochemical Properties.
Michael J Soth, Kang Le, Maria Emilia Di Francesco, Matthew M Hamilton, Gang Liu

J Med Chem· November 2020

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Identification of potent and selective MTH1 inhibitors.
Alessia Petrocchi, Elisabetta Leo, Naphtali J Reyna, Matthew M Hamilton, Xi Shi

Bioorg Med Chem Lett· March 2016

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Discovery of camphor-derived pyrazolones as 11β-hydroxysteroid dehydrogenase type 1 inhibitors.
Paul Gillespie, Sherrie Pietranico-Cole, Michael Myers, Joseph A Bilotta, Karin Conde-Knape, Matthew M Hamilton

Bioorg Med Chem Lett· June 2014

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Discovery of orally active carboxylic acid derivatives of 2-phenyl-5-trifluoromethyloxazole-4-carboxamide as potent diacylglycerol acyltransferase-1 inhibitors for the potential treatment of obesity and diabetes.
Yimin Qian, Stanley J Wertheimer, Mushtaq Ahmad, Adrian Wai-Hing Cheung, Fariborz Firooznia, Matthew M Hamilton

J Med Chem· April 2011

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