Publications by authors named "Matthew Schaich"

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Therapeutic 6-thio-deoxyguanosine inhibits telomere elongation in cancer cells by inducing a non-productive stalled telomerase complex.
Samantha L Sanford, Mareike Badstübner, Michael Gerber, William Mannherz, Noah Lampl, Matthew A Schaich

Nat Commun· December 2025

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Nucleosome unwrapping and PARP1 allostery drive affinities for chromatin and DNA breaks.
Matthew A Schaich, Tyler M Weaver, Jennifer A Rakowski, Vera Roginskaya, Liam P Leary

Nat Commun· December 2025

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The zinc finger of DNA ligase 3α binds to nucleosomes via an arginine anchor.
Ashna Nagpal, Matthew A Schaich, Tyler M Weaver, Vera Roginskaya, Annahita Sallmyr

Nat Commun· November 2025

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Molecular basis for CSB stimulation of the SNM1A DNA repair nuclease.
Rebecca Roddan, Matthew A Schaich, William J Nathan, Iulia Kis, Andrea Pierangelini

Res Sq· November 2025

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SON-dependent nuclear speckle rehabilitation alleviates proteinopathies.
William Dion, Yuren Tao, Maci Chambers, Shanshan Zhao, Riley K Arbuckle, Matthew A Schaich

Nat Commun· August 2025

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Nucleosome unwrapping and PARP1 allostery drive affinities for chromatin and DNA breaks.
Matthew A Schaich, Tyler M Weaver, Jennifer A Rakowski, Vera Roginskaya, Liam P Leary

bioRxiv· August 2025

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Chemotherapeutic 6-thio-2'-deoxyguanosine selectively targets and inhibits telomerase by inducing a non-productive telomere-bound telomerase complex.
Samantha L Sanford, Mareike Badstübner, Michael Gerber, William Mannherz, Noah Lampl, Matthew A Schaich

bioRxiv· June 2025

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SON-dependent nuclear speckle rehabilitation alleviates proteinopathies.
William Dion, Yuren Tao, Maci Chambers, Shanshan Zhao, Riley K Arbuckle, Matthew A Schaich

bioRxiv· April 2025

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The zinc finger of DNA Ligase 3α binds to nucleosomes via an arginine anchor.
Bennett Van Houten, Ashna Nagpal, Matthew Schaich, Tyler Weaver, Vera Roginskaya

Res Sq· March 2025

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Utilizing nuclear extracts to characterize protein: DNA interactions at the single molecule level.
Jennifer A Rakowski, Matthew A Schaich, Brittani L Schnable, Bennett Van Houten

Methods Enzymol· October 2024

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Thymine DNA glycosylase combines sliding, hopping, and nucleosome interactions to efficiently search for 5-formylcytosine.
Brittani L Schnable, Matthew A Schaich, Vera Roginskaya, Liam P Leary, Tyler M Weaver

Nat Commun· October 2024

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The human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNA.
Sarah R Hengel, Katherine G Oppenheimer, Chelsea M Smith, Matthew A Schaich, Hayley L Rein

Nat Commun· August 2024

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Thymine DNA glycosylase combines sliding, hopping, and nucleosome interactions to efficiently search for 5-formylcytosine.
Brittani L Schnable, Matthew A Schaich, Vera Roginskaya, Liam P Leary, Tyler M Weaver

bioRxiv· July 2024

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Single-molecule analysis of purified proteins and nuclear extracts: Insights from 8-oxoguanine glycosylase 1.
Matthew A Schaich, Tyler M Weaver, Vera Roginskaya, Bret D Freudenthal, Bennett Van Houten

DNA Repair (Amst)· February 2024

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The human Shu complex promotes RAD51 activity by modulating RPA dynamics on ssDNA.
Sarah R Hengel, Katherine Oppenheimer, Chelsea Smith, Matthew A Schaich, Hayley L Rein

bioRxiv· February 2024

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Single-molecule analysis of purified proteins and nuclear extracts: insights from 8-oxoguanine glycosylase 1.
Matthew A Schaich, Tyler M Weaver, Vera Roginskaya, Bret D Freudenthal, Bennett Van Houten

bioRxiv· November 2023

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Unlicensed origin DNA melting by MCV and SV40 polyomavirus LT proteins is independent of ATP-dependent helicase activity.
Li Wan, Sabrina Toland, Lindsey R Robinson-McCarthy, Nara Lee, Matthew A Schaich

Proc Natl Acad Sci U S A· July 2023

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UV-DDB stimulates the activity of SMUG1 during base excision repair of 5-hydroxymethyl-2'-deoxyuridine moieties.
Sunbok Jang, Sripriya J Raja, Vera Roginskaya, Matthew A Schaich, Simon C Watkins

Nucleic Acids Res· June 2023

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Single-molecule analysis of DNA-binding proteins from nuclear extracts (SMADNE).
Matthew A Schaich, Brittani L Schnable, Namrata Kumar, Vera Roginskaya, Rachel C Jakielski

Nucleic Acids Res· April 2023

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UV irradiation remodels the specificity landscape of transcription factors.
Zachery Mielko, Yuning Zhang, Harshit Sahay, Yiling Liu, Matthew A Schaich

Proc Natl Acad Sci U S A· March 2023

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Searching for DNA Damage: Insights From Single Molecule Analysis.
Matthew A Schaich, Bennett Van Houten

Front Mol Biosci· November 2021

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Single molecule analysis indicates stimulation of MUTYH by UV-DDB through enzyme turnover.
Sunbok Jang, Matthew A Schaich, Cindy Khuu, Brittani L Schnable, Chandrima Majumdar

Nucleic Acids Res· August 2021

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Mechanisms of nucleotide selection by telomerase.
Matthew A Schaich, Samantha L Sanford, Griffin A Welfer, Samuel A Johnson, Thu H Khoang

Elife· June 2020

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Structure and function relationships in mammalian DNA polymerases.
Nicole M Hoitsma, Amy M Whitaker, Matthew A Schaich, Mallory R Smith, Max S Fairlamb

Cell Mol Life Sci· January 2020

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Delayed Treatment With 4-Methylpyrazole Protects Against Acetaminophen Hepatotoxicity in Mice by Inhibition of c-Jun n-Terminal Kinase.
Jephte Y Akakpo, Anup Ramachandran, Luqi Duan, Matthew A Schaich, Matthew W Jaeschke

Toxicol Sci· July 2019

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