Publications by authors named "Matthew Waitkus"

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Oncogenic mutations deregulate the p53 pathway in primary mouse gliomas.
Vennesa Valentine, Abigail J Groth, Joshua Tolliver, Avneesh Saravanapavan, Spencer M Maingi, Matthew S Waitkus

bioRxiv· November 2025

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Loss of function of recapitulates phenotypes of alternative lengthening of telomeres in a primary mouse model of sarcoma.
Matthew Pierpoint, Warren Floyd, Amy J Wisdom, Lixia Luo, Yan Ma, Matthew S Waitkus

iScience· May 2025

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Mechanisms of telomere maintenance and associated therapeutic vulnerabilities in malignant gliomas.
Matthew S Waitkus, Elise N Erman, Zachary J Reitman, David M Ashley

Neuro Oncol· June 2024

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Understanding and therapeutically exploiting cGAS/STING signaling in glioblastoma.
Justin T Low, Michael C Brown, Zachary J Reitman, Joshua D Bernstock, James M Markert, Matthew S Waitkus

J Clin Invest· January 2024

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Interplay between ATRX and IDH1 mutations governs innate immune responses in diffuse gliomas.
Seethalakshmi Hariharan, Benjamin T Whitfield, Christopher J Pirozzi, Matthew S Waitkus, Michael C Brown

Nat Commun· January 2024

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Mining cancer genomes for change-of-metabolic-function mutations.
Kevin J Tu, Bill H Diplas, Joshua A Regal, Matthew S Waitkus, Christopher J Pirozzi

Commun Biol· November 2023

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Loss of function of leads to activation of alternative lengthening of telomeres in a primary mouse model of sarcoma.
Matthew Pierpoint, Warren Floyd, Amy J Wisdom, Lixia Luo, Yan Ma, Matthew S Waitkus

bioRxiv· November 2023

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Pooled genetic screens to identify vulnerabilities in TERT-promoter-mutant glioblastoma.
Kevin J Tu, Connor E Stewart, Peter G Hendrickson, Joshua A Regal, So Young Kim, Matthew S Waitkus

Oncogene· October 2023

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Cancer-associated SMARCAL1 loss-of-function mutations promote alternative lengthening of telomeres and tumorigenesis in telomerase-negative glioblastoma cells.
Heng Liu, Cheng Xu, Bill H Diplas, Alexandrea Brown, Laura M Strickland, Matthew S Waitkus

Neuro Oncol· September 2023

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Interplay between and mutations governs innate immune responses in diffuse gliomas.
Seethalakshmi Hariharan, Benjamin T Whitfield, Christopher J Pirozzi, Matthew S Waitkus, Michael C Brown

bioRxiv· April 2023

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Antitumor Activity of a Mitochondrial-Targeted HSP90 Inhibitor in Gliomas.
Shiyou Wei, Delong Yin, Shengnan Yu, Xiang Lin, Milan R Savani, Matthew Waitkus

Clin Cancer Res· May 2022

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Epigenetic STING silencing is developmentally conserved in gliomas and can be rescued by methyltransferase inhibition.
Justin T Low, Vidyalakshmi Chandramohan, Michelle L Bowie, Michael C Brown, Matthew S Waitkus

Cancer Cell· May 2022

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A Modified Nucleoside 6-Thio-2'-Deoxyguanosine Exhibits Antitumor Activity in Gliomas.
Shengnan Yu, Shiyou Wei, Milan Savani, Xiang Lin, Kuang Du, Matthew Waitkus

Clin Cancer Res· December 2021

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TP53 wild-type/PPM1D mutant diffuse intrinsic pontine gliomas are sensitive to a MDM2 antagonist.
Cheng Xu, Heng Liu, Christopher J Pirozzi, Lee H Chen, Paula K Greer, Matthew S Waitkus

Acta Neuropathol Commun· November 2021

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Targeting Isocitrate Dehydrogenase Mutations in Cancer: Emerging Evidence and Diverging Strategies.
Matthew S Waitkus, Hai Yan

Clin Cancer Res· January 2021

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Targeting Mutant PPM1D Sensitizes Diffuse Intrinsic Pontine Glioma Cells to the PARP Inhibitor Olaparib.
Zhaohui Wang, Cheng Xu, Bill H Diplas, Casey J Moure, Chin-Pu Jason Chen, Matthew S Waitkus

Mol Cancer Res· July 2020

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The integrated genomic and epigenomic landscape of brainstem glioma.
Lee H Chen, Changcun Pan, Bill H Diplas, Cheng Xu, Landon J Hansen, Matthew S Waitkus

Nat Commun· June 2020

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CRISPR Editing of Mutant IDH1 R132H Induces a CpG Methylation-Low State in Patient-Derived Glioma Models of G-CIMP.
Casey J Moure, Bill H Diplas, Lee H Chen, Rui Yang, Christopher J Pirozzi, Matthew S Waitkus

Mol Cancer Res· October 2019

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Non-invasive sensitive brain tumor detection using dual-modality bioimaging nanoprobe.
Yang Liu, Austin B Carpenter, Christopher J Pirozzi, Hsiangkuo Yuan, Matthew S Waitkus

Nanotechnology· July 2019

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Hereditary brain tumor with a homozygous germline mutation in PMS2: pedigree analysis and prenatal screening in a family with constitutional mismatch repair deficiency (CMMRD) syndrome.
Shahid Mahmood Baig, Ambrin Fatima, Muhammad Tariq, Tahir Naeem Khan, Zafar Ali, Matthew Waitkus

Fam Cancer· April 2019

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Sensitive and rapid detection of TERT promoter and IDH mutations in diffuse gliomas.
Bill H Diplas, Heng Liu, Rui Yang, Landon J Hansen, Alexis L Zachem, Matthew S Waitkus

Neuro Oncol· March 2019

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Biological Role and Therapeutic Potential of IDH Mutations in Cancer.
Matthew S Waitkus, Bill H Diplas, Hai Yan

Cancer Cell· August 2018

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The genomic landscape of TERT promoter wildtype-IDH wildtype glioblastoma.
Bill H Diplas, Xujun He, Jacqueline A Brosnan-Cashman, Heng Liu, Lee H Chen, Matthew S Waitkus

Nat Commun· May 2018

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Adaptive Evolution of the GDH2 Allosteric Domain Promotes Gliomagenesis by Resolving IDH1-Induced Metabolic Liabilities.
Matthew S Waitkus, Christopher J Pirozzi, Casey J Moure, Bill H Diplas, Landon J Hansen

Cancer Res· January 2018

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Loss Promotes Gliomagenesis via Aberrant Neural Stem Cell Proliferation and Differentiation.
Rui Yang, Lee H Chen, Landon J Hansen, Austin B Carpenter, Casey J Moure, Matthew S Waitkus

Cancer Res· November 2017

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