Publications by authors named "Matthias Frech"

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Reflectometric-based sensor arrays for the screening of kinase-inhibitor interactions and kinetic determination.
Viola Wurster, Peter Fechner, Günther Proll, Rebecca Pamies-Cuberos, Matthias Frech

Anal Bioanal Chem· December 2025

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Visualizing the transiently populated closed-state of human HSP90 ATP binding domain.
Faustine Henot, Elisa Rioual, Adrien Favier, Pavel Macek, Elodie Crublet, Matthias Frech

Nat Commun· December 2022

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NMR assignment of human HSP90 N-terminal domain bound to a long residence time resorcinol ligand.
Faustine Henot, Elodie Crublet, Matthias Frech, Jerome Boisbouvier

Biomol NMR Assign· October 2022

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Optimized precursor to simplify assignment transfer between backbone resonances and stereospecifically labelled valine and leucine methyl groups: application to human Hsp90 N-terminal domain.
Faustine Henot, Rime Kerfah, Ricarda Törner, Pavel Macek, Elodie Crublet, Matthias Frech

J Biomol NMR· July 2021

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Structure-kinetic relationship reveals the mechanism of selectivity of FAK inhibitors over PYK2.
Benedict-Tilman Berger, Marta Amaral, Daria B Kokh, Ariane Nunes-Alves, Djordje Musil, Matthias Frech

Cell Chem Biol· May 2021

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Estimation of Protein-Ligand Unbinding Kinetics Using Non-Equilibrium Targeted Molecular Dynamics Simulations.
Steffen Wolf, Marta Amaral, Maryse Lowinski, Francois Vallée, Djordje Musil, Matthias Frech

J Chem Inf Model· December 2019

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Estimation of Drug-Target Residence Times by τ-Random Acceleration Molecular Dynamics Simulations.
Daria B Kokh, Marta Amaral, Joerg Bomke, Ulrich Grädler, Djordje Musil, Matthias Frech

J Chem Theory Comput· July 2018

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Ligand-Induced Conformational Changes in HSP90 Monitored Time Resolved and Label Free-Towards a Conformational Activity Screening for Drug Discovery.
Jörn Güldenhaupt, Marta Amaral, Carsten Kötting, Jonas Schartner, Djordje Musil, Matthias Frech

Angew Chem Int Ed Engl· July 2018

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Ligand Desolvation Steers On-Rate and Impacts Drug Residence Time of Heat Shock Protein 90 (Hsp90) Inhibitors.
Doris A Schuetz, Lars Richter, Marta Amaral, Melanie Grandits, Ulrich Grädler, Matthias Frech

J Med Chem· May 2018

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Kinetics for Drug Discovery: an industry-driven effort to target drug residence time.
Doris A Schuetz, Wilhelmus Egbertus Arnout de Witte, Yin Cheong Wong, Bernhard Knasmueller, Lars Richter, Matthias Frech

Drug Discov Today· June 2017

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Structural and biophysical characterization of the Syk activation switch.
Ulrich Grädler, Daniel Schwarz, Verena Dresing, Djordje Musil, Jörg Bomke, Matthias Frech

J Mol Biol· January 2013

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Structure of the leech protein saratin and characterization of its binding to collagen.
Wolfram Gronwald, Jörg Bomke, Till Maurer, Barbara Domogalla, Fritz Huber, Matthias Frech

J Mol Biol· September 2008

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Ubiquitin protein ligase Nedd4 binds to connexin43 by a phosphorylation-modulated process.
Kerstin Leykauf, Mojibrahman Salek, Jörg Bomke, Matthias Frech, Wolf-Dieter Lehmann

J Cell Sci· September 2006

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Features of the Env leader protein and the N-terminal Gag domain of feline foamy virus important for virus morphogenesis.
Verena Geiselhart, Astrid Schwantes, Patrizia Bastone, Matthias Frech, Martin Löchelt

Virology· June 2003

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Crystal structure of the extracellular segment of integrin alpha Vbeta3 in complex with an Arg-Gly-Asp ligand.
Jian-Ping Xiong, Thilo Stehle, Rongguang Zhang, Andrzej Joachimiak, Matthias Frech

Science· April 2002

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