Publications by authors named "Matthias Machacek"

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A Semimechanistic Ocular Pharmacokinetic Model for ADVM-022 Gene Therapy Describing the Dose-Exposure Relationship in Monkeys and the Scaling to Human.
Florian Hugi, Jannik Vollmer, Lionel Renaud, Matthias Machacek

Mol Pharm· August 2025

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Intrathecal administration of Anti-Nogo-A antibody in macaque monkeys: Pharmacokinetics, tissue penetration and target interaction.
Pascal B Kunz, Michael A Maurer, Jannik Vollmer, Matthias Machacek, Oliver Weinmann

Neurotherapeutics· March 2025

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Author Correction: Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours.
Ignacio Melero, Maria de Miguel Luken, Guillermo de Velasco, Elena Garralda, Juan Martín-Liberal, Matthias Machacek

Nature· March 2025

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Prediction of Cardiac ATTR Depletion by NI006 (ALXN2220) Using Mechanistic PK/PD Modeling.
Aubin Michalon, Lionel Renaud, Matthias Machacek, Cédric Cortijo, Chandrasekhar Udata

Clin Pharmacol Ther· January 2025

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Neutralizing GDF-15 can overcome anti-PD-1 and anti-PD-L1 resistance in solid tumours.
Ignacio Melero, Maria de Miguel Luken, Guillermo de Velasco, Elena Garralda, Juan Martín-Liberal, Matthias Machacek

Nature· January 2025

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NfL concentration in CSF is a quantitative marker of the rate of neurodegeneration in aging and Huntington's disease: a semi-mechanistic model-based analysis.
Matthias Machacek, Elena Garcia-Montoya, Peter McColgan, Patricia Sanwald-Ducray, Norman Alan Mazer

Front Neurosci· July 2024

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Characterization of the Pharmacokinetic and Pharmacodynamic Profile of Apraglutide, a Glucagon-Like Peptide-2 Analog, in Healthy Volunteers.
Federico Bolognani, Annelieke C Kruithof, Pascal Schulthess, Matthias Machacek, Marieke L de Kam

J Pharmacol Exp Ther· August 2023

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Modeling the activation of the alternative complement pathway and its effects on hemolysis in health and disease.
Antonello Caruso, Jannik Vollmer, Matthias Machacek, Elod Kortvely

PLoS Comput Biol· October 2020

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Population Pharmacokinetic/Pharmacodynamic Modeling of Glenzocimab (ACT017) a Glycoprotein VI Inhibitor of Collagen-Induced Platelet Aggregation.
Lionel Renaud, Kristell Lebozec, Christine Voors-Pette, Peter Dogterom, Philippe Billiald, Matthias Machacek

J Clin Pharmacol· September 2020

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Pharmacokinetics-Pharmacodynamics of Enmetazobactam Combined with Cefepime in a Neutropenic Murine Thigh Infection Model.
Fabian Bernhard, Rajesh Odedra, Sylvie Sordello, Rossella Cardin, Samantha Franzoni, Matthias Machacek

Antimicrob Agents Chemother· May 2020

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Half-life extension and non-human primate pharmacokinetic safety studies of i-body AD-114 targeting human CXCR4.
Katherine Griffiths, Uli Binder, William McDowell, Rita Tommasi, Mark Frigerio, Matthias Machacek

MAbs· October 2019

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Safety and Tolerability, Pharmacokinetics, and Pharmacodynamics of ACT017, an Antiplatelet GPVI (Glycoprotein VI) Fab.
Christine Voors-Pette, Kristell Lebozec, Peter Dogterom, Laurie Jullien, Philippe Billiald, Matthias Machacek

Arterioscler Thromb Vasc Biol· May 2019

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Quantitative imaging of epithelial cell scattering identifies specific inhibitors of cell motility and cell-cell dissociation.
Dinah Loerke, Quint le Duc, Iris Blonk, Andre Kerstens, Emma Spanjaard, Matthias Machacek

Sci Signal· July 2012

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Protein kinase A governs a RhoA-RhoGDI protrusion-retraction pacemaker in migrating cells.
Eugene Tkachenko, Mohsen Sabouri-Ghomi, Olivier Pertz, Chungho Kim, Edgar Gutierrez, Matthias Machacek

Nat Cell Biol· June 2011

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Protrusion and actin assembly are coupled to the organization of lamellar contractile structures.
James I Lim, Mohsen Sabouri-Ghomi, Matthias Machacek, Clare M Waterman, Gaudenz Danuser

Exp Cell Res· August 2010

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Coordination of Rho GTPase activities during cell protrusion.
Matthias Machacek, Louis Hodgson, Christopher Welch, Hunter Elliott, Olivier Pertz

Nature· September 2009

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Cofilin activity downstream of Pak1 regulates cell protrusion efficiency by organizing lamellipodium and lamella actin networks.
Violaine Delorme, Matthias Machacek, Céline DerMardirossian, Karen L Anderson, Torsten Wittmann

Dev Cell· November 2007

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Photogrammetric and image processing aspects in quantitative flow visualization.
Matthias Machacek, Thomas Rosgen

Ann N Y Acad Sci· October 2002

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