Publications by authors named "Max Jan"

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A Molecular Glue Approach to Control the Half-Life of CRISPR-Based Technologies.
Vedagopuram Sreekanth, Max Jan, Kevin T Zhao, Donghyun Lim, Surached Siriwongsup

J Am Chem Soc· July 2025

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Mesothelin CAR T Cells Secreting Anti-FAP/Anti-CD3 Molecules Efficiently Target Pancreatic Adenocarcinoma and its Stroma.
Marc Wehrli, Samantha Guinn, Filippo Birocchi, Adam Kuo, Yi Sun, Max Jan

Clin Cancer Res· May 2024

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Targeting solid tumor antigens with chimeric receptors: cancer biology meets synthetic immunology.
Gabriele J Kembuan, Joanna Y Kim, Marcela V Maus, Max Jan

Trends Cancer· April 2024

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Chemical genetic control of cytokine signaling in CAR-T cells using lenalidomide-controlled membrane-bound degradable IL-7.
Michael C Kann, Emily M Schneider, Antonio J Almazan, Isabel C Lane, Amanda A Bouffard, Max Jan

Leukemia· March 2024

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Genetic retargeting of E3 ligases to enhance CAR T cell therapy.
Isabel C Lane, Gabriele Kembuan, Jeannie Carreiro, Michael C Kann, William Lin, Max Jan

Cell Chem Biol· February 2024

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Proteolysis-targeting chimeras with reduced off-targets.
Tuan M Nguyen, Vedagopuram Sreekanth, Arghya Deb, Praveen Kokkonda, Praveen K Tiwari, Max Jan

Nat Chem· February 2024

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Clonal hematopoiesis is associated with protection from Alzheimer's disease.
Hind Bouzid, Julia A Belk, Max Jan, Yanyan Qi, Chloé Sarnowski, Pradeep Natarajan

Nat Med· July 2023

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A molecular glue approach to control the half-life of CRISPR-based technologies.
Vedagopuram Sreekanth, Max Jan, Kevin T Zhao, Donghyun Lim, Jessie R Davis

bioRxiv· March 2023

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SEAKER cells coordinate cellular immunotherapy with localized chemotherapy.
Isabel C Lane, Max Jan

Trends Pharmacol Sci· October 2022

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Distinct cellular dynamics associated with response to CAR-T therapy for refractory B cell lymphoma.
Nicholas J Haradhvala, Mark B Leick, Katie Maurer, Satyen H Gohil, Rebecca C Larson, Max Jan

Nat Med· September 2022

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Calreticulin mutant myeloproliferative neoplasms induce MHC-I skewing, which can be overcome by an optimized peptide cancer vaccine.
Mathieu Gigoux, Morten O Holmström, Roberta Zappasodi, Joseph J Park, Stephane Pourpe, Max Jan

Sci Transl Med· June 2022

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Non-cleavable hinge enhances avidity and expansion of CAR-T cells for acute myeloid leukemia.
Mark B Leick, Harrison Silva, Irene Scarfò, Rebecca Larson, Bryan D Choi, Max Jan

Cancer Cell· May 2022

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CAR T cell killing requires the IFNγR pathway in solid but not liquid tumours.
Rebecca C Larson, Michael C Kann, Stefanie R Bailey, Nicholas J Haradhvala, Paula Montero Llopis, Max Jan

Nature· April 2022

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Clonal hematopoiesis in patients receiving chimeric antigen receptor T-cell therapy.
Peter G Miller, Adam S Sperling, Elliott J Brea, Mark B Leick, Geoffrey G Fell, Max Jan

Blood Adv· August 2021

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Cancer therapies based on targeted protein degradation - lessons learned with lenalidomide.
Max Jan, Adam S Sperling, Benjamin L Ebert

Nat Rev Clin Oncol· July 2021

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Reversible ON- and OFF-switch chimeric antigen receptors controlled by lenalidomide.
Max Jan, Irene Scarfò, Rebecca C Larson, Amanda Walker, Andrea Schmidts

Sci Transl Med· January 2021

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The CDK inhibitor CR8 acts as a molecular glue degrader that depletes cyclin K.
Mikołaj Słabicki, Zuzanna Kozicka, Georg Petzold, Yen-Der Li, Manisha Manojkumar, Max Jan

Nature· September 2020

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A cryptic imatinib-sensitive G3BP1-PDGFRB rearrangement in a myeloid neoplasm with eosinophilia.
Max Jan, Daniel E Grinshpun, Julian A Villalba, Paola Dal Cin, David B Sykes

Blood Adv· February 2020

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Patterns of substrate affinity, competition, and degradation kinetics underlie biological activity of thalidomide analogs.
Adam S Sperling, Michael Burgess, Hasmik Keshishian, Jessica A Gasser, Shruti Bhatt, Max Jan

Blood· July 2019

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Recurrent genetic HLA loss in AML relapsed after matched unrelated allogeneic hematopoietic cell transplantation.
Max Jan, Matthew J Leventhal, Elizabeth A Morgan, Jordan C Wengrod, Anwesha Nag, Jane Baronas

Blood Adv· July 2019

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Clonal hematopoiesis.
Max Jan, Benjamin L Ebert, Siddhartha Jaiswal

Semin Hematol· January 2017

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COPA mutations impair ER-Golgi transport and cause hereditary autoimmune-mediated lung disease and arthritis.
Levi B Watkin, Birthe Jessen, Wojciech Wiszniewski, Timothy J Vece, Max Jan

Nat Genet· June 2015

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Development and validation of an app-based cell counter for use in the clinical laboratory setting.
Alexander C Thurman, Jessica L Davis, Max Jan, Charles E McCulloch, Benjamin D Buelow

J Pathol Inform· February 2015

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Clonal evolution of preleukemic hematopoietic stem cells precedes human acute myeloid leukemia.
Max Jan, Thomas M Snyder, M Ryan Corces-Zimmerman, Paresh Vyas, Irving L Weissman

Sci Transl Med· August 2012

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