Publications by authors named "Megan J Bester"

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In silico and in vitro evaluation of flavonoid derivatives for diabetes management: molecular dynamics, and enzyme kinetics for pancreatic alpha-amylase and alpha-glucosidase.
Jamie McMillan, Megan Jean Bester, Zeno Apostolides

In Silico Pharmacol· November 2025

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Enhanced Gram-Negative Membrane Disruption and In Vivo Efficacy via Lysine-Arginine Enrichment of Opis16a.
Mandelie van der Walt, Carel B Oosthuizen, Miruna Serian, Christian D Lorenz, A James Mason, Megan J Bester

ACS Med Chem Lett· June 2025

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In silico docking and ADMET studies on clinical targets for type 2 diabetes correlated to in vitro inhibition of pancreatic alpha-amylase and alpha-glucosidase by rutin, caffeic acid, p-coumaric acid, and vanillin.
Jamie McMillan, Megan Jean Bester, Zeno Apostolides

In Silico Pharmacol· March 2025

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Carboxy-Amidated AamAP1-Lys has Superior Conformational Flexibility and Accelerated Killing of Gram-Negative Bacteria.
Rosalind J Van Wyk, June C Serem, Carel B Oosthuizen, Dorothy Semenya, Miruna Serian, Megan J Bester

Biochemistry· February 2025

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Improving the Activity and Selectivity of a Scorpion-Derived Peptide, A3a, against through Rational Design.
Dalton S Möller, Mandelie van der Walt, Carel Oosthuizen, Miruna Serian, June C Serem, Megan J Bester

ACS Omega· February 2025

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Two Triterpenoids, ARM-2 and RA-5, From Exhibit the Potential to Modulate Lipolysis and Lipogenesis in Cultured 3T3-L1 Adipocytes.
Musawenkosi Ndlovu, June C Serem, Megan J Bester, Zeno Apostolides, Andrew R Opoku

J Lipids· October 2024

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QSAR Reveals Decreased Lipophilicity of Polar Residues Determines the Selectivity of Antimicrobial Peptide Activity.
Mandelie van der Walt, Dalton S Möller, Rosalind J van Wyk, Philip M Ferguson, Charlotte K Hind, Megan J Bester

ACS Omega· June 2024

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Tryptophan End-Tagging Confers Antifungal Activity on a Tick-Derived Peptide by Triggering Reactive Oxygen Species Production.
Court K Chiramba, Dalton S Möller, Christian D Lorenz, Rumbidzai R Chirombo, A James Mason, Megan J Bester

ACS Omega· April 2024

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Adverse neurological effects after exposure to copper, manganese, and mercury mixtures in a Spraque-Dawley rat model: an ultrastructural investigation.
Maxine Draper, Megan Jean Bester, Mia-Jeanne Van Rooy, Hester Magdalena Oberholzer

Ultrastruct Pathol· November 2023

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Gastrointestinal Effects on the Antioxidant and Immunomodulatory Properties of South African Fynbos Honey.
Innocentia Botlhale Magoshi, Anwani Wendy Nekhumbe, Mohammed Auwal Ibrahim, June Cheptoo Serem, Megan Jean Bester

Int J Food Sci· November 2023

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Triterpenoids from Exhibit Hypocholesterolemic Potential via Regulation of Cholesterol Biosynthesis and Stimulation of Low-Density Lipoprotein Uptake in HepG2 Cells.
Musawenkosi Ndlovu, June C Serem, Mamoalosi A Selepe, Andrew R Opoku, Megan J Bester

ACS Omega· August 2023

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Renal Papillary Necrosis (RPN) in an African Population: Disease Patterns, Relevant Pathways, and Management.
Guy Roger Gaudji, Meshack Bida, Marius Conradie, Botle Precious Damane, Megan Jean Bester

Biomedicines· December 2022

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Stability, Morphology, and Effects of In Vitro Digestion on the Antioxidant Properties of Polyphenol Inclusion Complexes with β-Cyclodextrin.
Sunday Ntuli, Machel Leuschner, Megan J Bester, June C Serem

Molecules· June 2022

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Antifungal activity and mode of action of synthetic peptides derived from the tick OsDef2 defensin.
Kabuzi R Mbuayama, Helena Taute, Adam A Strӧmstedt, Megan J Bester, Anabella R M Gaspar

J Pept Sci· May 2022

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Effect of simulated in vitro upper gut digestion of processed cowpea beans on phenolic composition, antioxidant properties and cellular protection.
Franklin B Apea-Bah, June C Serem, Megan J Bester, Kwaku G Duodu, Trust Beta

Food Res Int· December 2021

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Inhibition of α-glucosidase and α-amylase by herbal compounds for the treatment of type 2 diabetes: A validation of in silico reverse docking with in vitro enzyme assays.
Morné Tolmie, Megan Jean Bester, Zeno Apostolides

J Diabetes· October 2021

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Antioxidant properties and inhibition of lipid formation in 3T3-L1 adipocytes of in vitro digested mageu, a commercial sample.
Haleema Nathu, Kabuzi R Mbuyama, Martin Adarkwah-Yiadom, June C Serem, Mohammed Auwal Ibrahim, Megan J Bester

J Food Biochem· October 2021

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Hydrothermal Processing and In Vitro Simulated Human Digestion Affects the Bioaccessibility and Bioactivity of Phenolic Compounds in African Pumpkin () Leaves.
Siphosanele Mafa Moyo, June C Serem, Megan J Bester, Vuyo Mavumengwana, Eugenie Kayitesi

Molecules· August 2021

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Adverse cardiovascular effects of exposure to cadmium and mercury alone and in combination on the cardiac tissue and aorta of Sprague-Dawley rats.
Sandra Arbi, Megan Jean Bester, Liselle Pretorius, Hester Magdalena Oberholzer

J Environ Sci Health A Tox Hazard Subst Environ Eng· July 2021

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The dipeptidyl peptidase IV inhibitory activity and multifunctional antidiabetic properties of SQSPA: Structure - Activity relationship evaluated with alanine scanning.
Mohammed Auwal Ibrahim, June C Serem, Megan J Bester, Anabella R M Gaspar

Int J Biol Macromol· October 2020

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Ultrastructural alterations of whole blood by copper, manganese and mercury metal mixtures using a chronic in vivo model of coagulation.
Maxine Janse van Rensburg, Mia-Jeanne van Rooy, Megan Jean Bester, Hester Magdalena Oberholzer

Environ Toxicol Pharmacol· April 2020

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Induction of hepatic portal fibrosis, mitochondria damage, and extracellular vesicle formation in Sprague-Dawley rats exposed to copper, manganese, and mercury, alone and in combination.
Priyanka Dhanraj, Chantelle Venter, Megan Jean Bester, Hester Magdalena Oberholzer

Ultrastruct Pathol· March 2020

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Antimicrobial function of short amidated peptide fragments from the tick-derived OsDef2 defensin.
Naadhira O Ismail, Clerisa Odendaal, June C Serem, Adam A Strömstedt, Megan J Bester

J Pept Sci· December 2019

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Structure - Function Analysis of Peptide Analogs of SQSPA with Respect to α-glucosidase and α-amylase Inhibition.
Mohammed A Ibrahim, June C Serem, Megan J Bester, Albert W Neitz, Anabella R M Gaspar

Protein Pept Lett· July 2019

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Oral exposure to cadmium and mercury alone and in combination causes damage to the lung tissue of Sprague-Dawley rats.
Sirasha Venketsamy Koopsamy Naidoo, Megan Jean Bester, Sandra Arbi, Chantelle Venter, Priyanka Dhanraj

Environ Toxicol Pharmacol· July 2019

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