Publications by authors named "Megan M Simonds"

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Pathogenesis of juvenile idiopathic arthritis.
Megan M Simonds, AnneMarie C Brescia

Curr Opin Rheumatol· September 2025

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Adalimumab Effectively Decreases Inflammation Downstream of TNFα Signaling in Synoviocytes from Extended Oligoarticular Juvenile Idiopathic Arthritis.
Megan M Simonds, Samuel T Freer, Lina Al-Jaberi, AnneMarie C Brescia

Rheumatol Ther· February 2024

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Methotrexate inhibits BMP4 and abrogates the hypertrophic chondrocyte phenotype of synovial fibroblasts in juvenile idiopathic arthritis.
Megan M Simonds, Samuel T Freer, Anne Marie C Brescia

Pediatr Rheumatol Online J· January 2024

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CCL24, CXCL9 and CXCL10 are increased in synovial fluid in patients with juvenile idiopathic arthritis requiring advanced treatment.
Lina Al-Jaberi, Megan M Simonds, Anne Marie C Brescia

Rheumatology (Oxford)· July 2023

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Single-cell analysis reveals heterogeneity of juvenile idiopathic arthritis fibroblast-like synoviocytes with implications for disease subtype.
Megan M Simonds, Kathleen E Sullivan, AnneMarie C Brescia

Arthritis Res Ther· September 2022

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The culture microenvironment of juvenile idiopathic arthritis synovial fibroblasts is favorable for endochondral bone formation through BMP4 and repressed by chondrocytes.
Megan M Simonds, Amanda R Schlefman, Suzanne M McCahan, Kathleen E Sullivan, Carlos D Rose

Pediatr Rheumatol Online J· May 2021

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Juvenile idiopathic arthritis fibroblast-like synoviocytes influence chondrocytes to alter BMP antagonist expression demonstrating an interaction between the two prominent cell types involved in endochondral bone formation.
Megan M Simonds, Amanda R Schlefman, Suzanne M McCahan, Kathleen E Sullivan, Carlos D Rose

Pediatr Rheumatol Online J· November 2020

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Prior to extension, Transcriptomes of fibroblast-like Synoviocytes from extended and Polyarticular juvenile idiopathic arthritis are indistinguishable.
AnneMarie C Brescia, Megan M Simonds, Suzanne M McCahan, Kathleen E Sullivan, Carlos D Rose

Pediatr Rheumatol Online J· January 2018

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Secretion of pro-inflammatory cytokines and chemokines and loss of regulatory signals by fibroblast-like synoviocytes in juvenile idiopathic arthritis.
AnneMarie C Brescia, Megan M Simonds, Kathleen E Sullivan, Carlos D Rose

Proteomics Clin Appl· May 2017

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The role of transforming growth factor β signaling in fibroblast-like synoviocytes from patients with oligoarticular juvenile idiopathic arthritis: dysregulation of transforming growth factor β signaling, including overexpression of bone morphogenetic protein 4, may lead to a chondrocyte phenotype and may contribute to bony hypertrophy.
Annemarie C Brescia, Megan M Simonds, Suzanne M McCahan, Paul T Fawcett, Carlos D Rose

Arthritis Rheumatol· May 2014

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