Publications by authors named "Megan Shram"

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Assessment of the physical dependence potential of difelikefalin: Randomized placebo-controlled study in patients receiving hemodialysis.
Robert H Spencer, Catherine Munera, Megan J Shram, Frédérique Menzaghi

Clin Transl Sci· September 2023

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The novel uncompetitive NMDA receptor antagonist esmethadone (REL-1017) has no meaningful abuse potential in recreational drug users.
Megan J Shram, Jack E Henningfield, Glen Apseloff, Charles W Gorodetzky, Sara De Martin

Transl Psychiatry· June 2023

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Oral, intranasal, and intravenous abuse potential of serdexmethylphenidate, a novel prodrug of d-methylphenidate.
Megan J Shram, Beatrice Setnik, Lynn Webster, Sven Guenther, Travis C Mickle

Curr Med Res Opin· July 2022

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REL-1017 (esmethadone; D-methadone) does not cause reinforcing effect, physical dependence and withdrawal signs in Sprague Dawley rats.
Jack Henningfield, David Gauvin, Francesco Bifari, Reginald Fant, Megan Shram

Sci Rep· July 2022

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Evaluation of the abuse potential of difelikefalin, a selective kappa-opioid receptor agonist, in recreational polydrug users.
Megan J Shram, Robert H Spencer, Jenny Qian, Catherine L Munera, Michael E Lewis

Clin Transl Sci· February 2022

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Identification of Optimal Measures of Human Abuse Potential: A Post Hoc Assessment of 19 Studies.
Megan J Shram, Naama Levy-Cooperman, Sian Ratcliffe, Catherine Mills, Cynthia Bartlett

J Clin Psychopharmacol· July 2021

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Interaction of Ethanol and Oral ANS-6637, a Selective ALDH2 Inhibitor in Males: A Randomized, Double-Blind, Placebo-Controlled, Single-Ascending Dose Cohort Study.
Stephanie S O'Malley, Megan J Shram, Naama Levy-Cooperman, Bradley Vince, Peter M Strumph

Alcohol Clin Exp Res· September 2020

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Evaluation of the oral human abuse potential of Oxycodone DETERx® formulation (Xtampza® ER).
Diana Meske, Ernest A Kopecky, Steven Passik, Megan J Shram

J Opioid Manag· March 2019

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Abuse Potential of Buprenorphine/Samidorphan Combination Compared to Buprenorphine and Placebo: A Phase 1 Randomized Controlled Trial.
Sanjeev Pathak, Bradley Vince, Debra Kelsh, Megan J Shram, Beatrice Setnik

J Clin Pharmacol· February 2019

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Pharmacokinetic and Pharmacodynamic Correlations From 2 Studies Evaluating Abuse Potential of Hydrocodone Extended-Release Tablets.
Kerri A Schoedel, Michael Gillespie, Naama Levy-Cooperman, Megan J Shram, Laura Rabinovich-Guilatt

Clin Pharmacol Drug Dev· January 2019

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Evaluating the abuse potential of opioids and abuse-deterrent -opioid formulations: A review of clinical study methodology.
Beatrice Setnik, Kerri A Schoedel, Naama Levy-Cooperman, Megan Shram, Glenn C Pixton

J Opioid Manag· April 2018

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Assessment of Pharmacokinetic and Pharmacodynamic Interactions Between Albumin-Fused Mutated Butyrylcholinesterase and Intravenously Administered Cocaine in Recreational Cocaine Users.
Megan J Shram, Orit Cohen-Barak, Bijan Chakraborty, Merav Bassan, Kerri A Schoedel

J Clin Psychopharmacol· August 2015

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Use of Remifentanil in a Novel Clinical Paradigm to Characterize Onset and Duration of Opioid Blockade by Samidorphan, a Potent μ-Receptor Antagonist.
Megan J Shram, Bernard Silverman, Elliot Ehrich, Edward M Sellers, Ryan Turncliff

J Clin Psychopharmacol· June 2015

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Abuse potential of intravenous oxycodone/naloxone solution in nondependent recreational drug users.
Salvatore V Colucci, Peter J Perrino, Megan Shram, Cynthia Bartlett, Yi Wang

Clin Drug Investig· June 2014

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Abuse potential, pharmacokinetics, pharmacodynamics, and safety of intranasally administered crushed oxycodone HCl abuse-deterrent controlled-release tablets in recreational opioid users.
Stephen C Harris, Peter J Perrino, Ira Smith, Megan J Shram, Salvatore V Colucci

J Clin Pharmacol· April 2014

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Effects of stressors on the reinforcing efficacy of nicotine in adolescent and adult rats.
Sheng Zou, Douglas Funk, Megan J Shram, A D Lê

Psychopharmacology (Berl)· April 2014

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Sex differences in yohimbine-induced increases in the reinforcing efficacy of nicotine in adolescent rats.
Sophia Li, Sheng Zou, Kathleen Coen, Douglas Funk, Megan J Shram

Addict Biol· March 2014

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Assessing the subjective and physiological effects of intranasally administered crushed extended-release morphine formulations with and without a sequestered naltrexone core in recreational opioid users.
Beatrice Setnik, Veeraindar Goli, Naama Levy-Cooperman, Catherine Mills, Megan Shram

Pain Res Manag· March 2014

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Differences in the in vitro and in vivo pharmacokinetic profiles of once-daily modified-release methylphenidate formulations in Canada: examination of current bioequivalence criteria.
Megan J Shram, Anne Marie Quinn, Nancy Chen, Janice Faulknor, Doanh Luong

Clin Ther· May 2012

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Evaluation of the abuse potential of extended release hydromorphone versus immediate release hydromorphone.
Megan J Shram, Gayatri Sathyan, Sarita Khanna, Iulia Cristina Tudor, Rajneesh Nath

J Clin Psychopharmacol· February 2010

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Adolescent male Wistar rats are more responsive than adult rats to the conditioned rewarding effects of intravenously administered nicotine in the place conditioning procedure.
Megan J Shram, Anh D Lê

Behav Brain Res· January 2010

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Interactions between age and the aversive effects of nicotine withdrawal under mecamylamine-precipitated and spontaneous conditions in male Wistar rats.
Megan J Shram, Eric C K Siu, Zhaoxia Li, Rachel F Tyndale, Anh D Lê

Psychopharmacology (Berl)· June 2008

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Nicotine self-administration, extinction responding and reinstatement in adolescent and adult male rats: evidence against a biological vulnerability to nicotine addiction during adolescence.
Megan J Shram, Douglas Funk, Zhaoxia Li, Anh D Lê

Neuropsychopharmacology· March 2008

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Age differences in the spontaneous acquisition of nicotine self-administration in male Wistar and Long-Evans rats.
Megan J Shram, Zhaoxia Li, Anh D Lê

Psychopharmacology (Berl)· March 2008

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Acute nicotine enhances c-fos mRNA expression differentially in reward-related substrates of adolescent and adult rat brain.
Megan J Shram, Douglas Funk, Zhaoxia Li, A D Lê

Neurosci Lett· May 2007

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