Publications by authors named "Melanie Cornpropst"

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First-in-Human Study of the Safety, Tolerability, Pharmacokinetics, and Pharmacodynamics of Oral Complement Factor D Inhibitor BCX9930 in Healthy Participants.
Matthew Davidson, Xilin Chen, Amanda Mathis, Sylvia Dobo, Melanie Cornpropst

J Clin Pharmacol· September 2025

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Population pharmacokinetic modeling and simulations of berotralstat for prophylactic treatment of attacks of hereditary angioedema.
Amanda Mathis, Mark Sale, Melanie Cornpropst, William P Sheridan, Shu Chin Ma

Clin Transl Sci· April 2022

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Oral once-daily berotralstat for the prevention of hereditary angioedema attacks: A randomized, double-blind, placebo-controlled phase 3 trial.
Bruce Zuraw, William R Lumry, Douglas T Johnston, Emel Aygören-Pürsün, Aleena Banerji, Melanie Cornpropst

J Allergy Clin Immunol· July 2021

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Oral berotralstat for the prophylaxis of hereditary angioedema attacks in patients in Japan: A phase 3 randomized trial.
Isao Ohsawa, Daisuke Honda, Yusuke Suzuki, Tomoo Fukuda, Keisuke Kohga, Melanie Cornpropst

Allergy· June 2021

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Long-term safety and effectiveness of berotralstat for hereditary angioedema: The open-label APeX-S study.
Henriette Farkas, Marcin Stobiecki, Jonny Peter, Tamar Kinaciyan, Marcus Maurer, Melanie Cornpropst

Clin Transl Allergy· June 2021

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Oral Plasma Kallikrein Inhibitor for Prophylaxis in Hereditary Angioedema.
Emel Aygören-Pürsün, Anette Bygum, Vesna Grivcheva-Panovska, Markus Magerl, Jochen Graff, Melanie Cornpropst

N Engl J Med· July 2018

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Prophylaxis of hereditary angioedema attacks: A randomized trial of oral plasma kallikrein inhibition with avoralstat.
Emel Aygören-Pürsün, Markus Magerl, Jochen Graff, Inmaculada Martinez-Saguer, Wolfhart Kreuz, Melanie Cornpropst

J Allergy Clin Immunol· September 2016

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Correction to Discovery of Ledipasvir (GS-5885): A Potent, Once-Daily Oral NS5A Inhibitor for the Treatment of Hepatitis C Virus Infection.
John O Link, James G Taylor, Lianhong Xu, Michael Mitchell, Hongyan Guo, Melanie Cornpropst

J Med Chem· August 2016

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Discovery of ledipasvir (GS-5885): a potent, once-daily oral NS5A inhibitor for the treatment of hepatitis C virus infection.
John O Link, James G Taylor, Lianhong Xu, Michael Mitchell, Hongyan Guo, Melanie Cornpropst

J Med Chem· March 2014

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Sofosbuvir (GS-7977) plus peginterferon/ribavirin in treatment-naïve patients with HCV genotype 1: a randomized, 28-day, dose-ranging trial.
Maribel Rodriguez-Torres, Eric Lawitz, Kris V Kowdley, David R Nelson, Edwin Dejesus, Melanie T Cornpropst

J Hepatol· April 2013

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Pharmacokinetics, safety, and tolerability of GS-9851, a nucleotide analog polymerase inhibitor for hepatitis C virus, following single ascending doses in healthy subjects.
Jill Denning, Melanie Cornpropst, Stephen D Flach, Michelle M Berrey, William T Symonds

Antimicrob Agents Chemother· March 2013

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Pharmacokinetics, pharmacodynamics, and tolerability of GS-9851, a nucleotide analog polymerase inhibitor, following multiple ascending doses in patients with chronic hepatitis C infection.
Eric Lawitz, Maribel Rodriguez-Torres, Jill M Denning, Efsevia Albanis, Melanie Cornpropst

Antimicrob Agents Chemother· March 2013

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A phase 2, randomized, double-blind, placebo-controlled study of GS-9450 in subjects with nonalcoholic steatohepatitis.
Vlad Ratziu, Muhammad Y Sheikh, Arun J Sanyal, Joseph K Lim, Hari Conjeevaram, Melanie Cornpropst

Hepatology· February 2012

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