Publications by authors named "Melanie Higgins"

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Structure and Activity of a β-Mannosidase Involved in Core N-Glycan Degradation.
Grace Zea, Julianna Landry, Alexandra Winchester, Shruti Sharma, Melanie A Higgins

Proteins· December 2025

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Structural insights into a fucosidase involved in fucoidan degradation.
Brooke Bailey, Alexandra Winchester, Dylan McClain, Madeline Clingaman, Melanie A Higgins

Acta Crystallogr F Struct Biol Commun· November 2025

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Conversion of a Heme-Dependent Dehydratase to a Piperazate Synthase Reveals the Role of the Heme Propionate Group in N-N Bond-Formation.
Melanie A Higgins, Nana Mirotadze, Xinjie Shi, Elesha R Hoffarth, Yi-Ling Du

J Am Chem Soc· October 2025

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2-Deoxy-4---inosose (DEI) is the Product of EboD, a Highly Conserved Dehydroquinate Synthase-like Enzyme in Bacteria and Eustigmatophyte Algae.
Samuel Tanoeyadi, Wei Zhou, Andrew R Osborn, Takeshi Tsunoda, Arash Samadi, Melanie A Higgins

ACS Chem Biol· November 2024

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Identification and analysis of a unique group of glycoside hydrolase family 188 sequences with an altered sulfonate binding residue.
Anne E Backlund, Melanie A Higgins

MicroPubl Biol· September 2024

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A -inositol dehydrogenase involved in aminocyclitol biosynthesis of hygromycin A.
Michael O Akintubosun, Melanie A Higgins

Beilstein J Org Chem· March 2024

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Clozapine re-challenge and initiation following neutropenia: a review and case series of 14 patients in a high-secure forensic hospital.
Edward Silva, Melanie Higgins, Barbara Hammer, Paul Stephenson

Ther Adv Psychopharmacol· June 2021

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Generating a fucose permease deletion mutant in Bifidobacterium longum subspecies infantis ATCC 15697.
Melanie A Higgins, Katherine S Ryan

Anaerobe· April 2021

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N-Glycan Degradation Pathways in Gut- and Soil-Dwelling Actinobacteria Share Common Core Genes.
Melanie A Higgins, Gregor Tegl, Spencer S MacDonald, Gregory Arnal, Harry Brumer

ACS Chem Biol· April 2021

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Erratum for Beskrovnaya et al., "Comparative Genomics Identified a Genetic Locus in Plant-Associated spp. That Is Necessary for Induced Systemic Susceptibility".
Polina Beskrovnaya, Ryan A Melnyk, Zhexian Liu, Yang Liu, Melanie A Higgins

mBio· August 2020

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Clozapine rechallenge and initiation despite neutropenia- a practical, step-by-step guide.
Edward Silva, Melanie Higgins, Barbara Hammer, Paul Stephenson

BMC Psychiatry· June 2020

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Comparative Genomics Identified a Genetic Locus in Plant-Associated spp. That Is Necessary for Induced Systemic Susceptibility.
Polina Beskrovnaya, Ryan A Melnyk, Zhexian Liu, Yang Liu, Melanie A Higgins

mBio· June 2020

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Convergent biosynthetic transformations to a bacterial specialized metabolite.
Yi-Ling Du, Melanie A Higgins, Guiyun Zhao, Katherine S Ryan

Nat Chem Biol· November 2019

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An Asymmetric Reductase That Intercepts Acyclic Imino Acids Produced by a Partner Oxidase.
Jin Guo, Melanie A Higgins, Phillip Daniel-Ivad, Katherine S Ryan

J Am Chem Soc· August 2019

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A heme-dependent enzyme forms the nitrogen-nitrogen bond in piperazate.
Yi-Ling Du, Hai-Yan He, Melanie A Higgins, Katherine S Ryan

Nat Chem Biol· August 2017

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Structural characterization of the PTS IIA and IIB proteins associated with pneumococcal fucose utilization.
Melanie A Higgins, Aileen M Hamilton, Alisdair B Boraston

Proteins· May 2017

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Structure aided design of a Neu5Gc specific lectin.
Christopher J Day, Adrienne W Paton, Melanie A Higgins, Lucy K Shewell, Freda E-C Jen

Sci Rep· May 2017

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The Pneumococcal Alpha-Glycerophosphate Oxidase Enhances Nasopharyngeal Colonization through Binding to Host Glycoconjugates.
Layla K Mahdi, Melanie A Higgins, Christopher J Day, Joe Tiralongo, Lauren E Hartley-Tassell

EBioMedicine· April 2017

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A Second β-Hexosaminidase Encoded in the Streptococcus pneumoniae Genome Provides an Expanded Biochemical Ability to Degrade Host Glycans.
Melissa Robb, Craig S Robb, Melanie A Higgins, Joanne K Hobbs, James C Paton

J Biol Chem· December 2015

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The cholesterol-dependent cytolysins pneumolysin and streptolysin O require binding to red blood cell glycans for hemolytic activity.
Lucy K Shewell, Richard M Harvey, Melanie A Higgins, Christopher J Day, Lauren E Hartley-Tassell

Proc Natl Acad Sci U S A· December 2014

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Unravelling the multiple functions of the architecturally intricate Streptococcus pneumoniae β-galactosidase, BgaA.
Anirudh K Singh, Benjamin Pluvinage, Melanie A Higgins, Ankur B Dalia, Shireen A Woodiga

PLoS Pathog· September 2014

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Structural and functional analysis of fucose-processing enzymes from Streptococcus pneumoniae.
Melanie A Higgins, Michael D Suits, Candace Marsters, Alisdair B Boraston

J Mol Biol· April 2014

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Structure of the fucose mutarotase from Streptococcus pneumoniae in complex with L-fucose.
Melanie A Higgins, Alisdair B Boraston

Acta Crystallogr Sect F Struct Biol Cryst Commun· December 2011

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Inhibition of the pneumococcal virulence factor StrH and molecular insights into N-glycan recognition and hydrolysis.
Benjamin Pluvinage, Melanie A Higgins, D Wade Abbott, Craig Robb, Ankur B Dalia

Structure· November 2011

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