Publications by authors named "Melek Simsek"

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Early Crohn's disease: can we change the disease course?
Geert D'Haens, Melek Simsek

Nat Rev Gastroenterol Hepatol· June 2025

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Early therapeutic drug monitoring helps to identify inflammatory bowel disease patients with a high risk to fail thiopurine treatment.
Debbie S Deben, Bjorn Winkens, Sofia A W van Moorsel, Brigit P C van Oijen, Paul Bus, Melek Simsek

Br J Clin Pharmacol· December 2024

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Multicentre study and systematic review: Allopurinol exposure during pregnancy.
Femke Crouwel, Melek Simsek, Marjon A de Boer, Dirk P van Asseldonk, Abha Bhalla

Aliment Pharmacol Ther· August 2024

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Drug rediscovery in gastroenterology: from off-label to on-label use of thioguanine in inflammatory bowel disease.
Nanne K H de Boer, Melek Simsek, Berrie Meijer, Markus F Neurath, Ad van Bodegraven

Gut· October 2023

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Rectally Administrated Thioguanine for Distal Ulcerative Colitis: A Multicenter Case Series.
Femke Crouwel, Melek Simsek, Amarylle S van Doorn, Chris J J Mulder, Hans J C Buiter

Inflamm Bowel Dis· June 2023

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Thioguanine is Effective as Maintenance Therapy for Inflammatory Bowel Disease: A Prospective Multicentre Registry Study.
Melek Simsek, Femke Schepers, Sigal Kaplan, Dirk van Asseldonk, Petra van Boeckel

J Crohns Colitis· June 2023

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Exposure to Thioguanine During 117 Pregnancies in Women With Inflammatory Bowel Disease.
Femke Crouwel, Melek Simsek, Marjon A de Boer, Chris J J Mulder, Emma M van Andel

J Crohns Colitis· May 2023

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Predictive Algorithm for Thiopurine-Induced Hepatotoxicity in Inflammatory Bowel Disease Patients.
Sofia A W van Moorsel, Debbie S Deben, Rob H Creemers, Bjorn Winkens, Paul Bus, Melek Simsek

Ther Drug Monit· December 2022

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Correction to: Efficacy, safety and drug survival of thioguanine as maintenance treatment for inflammatory bowel disease: a retrospective multi-centre study in the United Kingdom.
Ahmed B Bayoumy, Elsa L S A van Liere, Melek Simsek, Ben Warner, Aathavan Loganayagam

BMC Gastroenterol· April 2022

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Thioguanine Therapy in Inflammatory Bowel Diseases. A Practical Guide.
Femke Crouwel, Melek Simsek, Chris Jj Mulder, Hans Jc Buiter, Nanne K De Boer

J Gastrointestin Liver Dis· December 2020

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Efficacy, safety and drug survival of thioguanine as maintenance treatment for inflammatory bowel disease: a retrospective multi-centre study in the United Kingdom.
Ahmed B Bayoumy, Elsa L S A van Liere, Melek Simsek, Ben Warner, Aathavan Loganayagam

BMC Gastroenterol· September 2020

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Letter: off-label use of hyperbaric oxygen therapy in inflammatory bowel disease-Authors' reply.
Melek Simsek, Nanne K H de Boer

Aliment Pharmacol Ther· July 2020

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A comparative analysis of tioguanine versus low-dose thiopurines combined with allopurinol in inflammatory bowel disease patients.
Vince B C Biemans, Edo Savelkoul, Ruben Y Gabriëls, Melek Simsek, Gerard Dijkstra

Aliment Pharmacol Ther· June 2020

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The continuous rediscovery and the benefit-risk ratio of thioguanine, a comprehensive review.
Ahmed B Bayoumy, Melek Simsek, Margien L Seinen, Chris J J Mulder, Azhar Ansari

Expert Opin Drug Metab Toxicol· February 2020

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Pseudomyxoma peritonei of the appendix after ileocecal resection: Expect the unexpected.
Melek Simsek, Annemiek J Linn, Nanne K H de Boer

Dig Liver Dis· October 2019

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Mesalazine and Nephrolithiasis: Leave No Stone Unturned.
Melek Simsek, Nanne K H de Boer

Am J Gastroenterol· August 2019

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Sustained effectiveness, safety and therapeutic drug monitoring of tioguanine in a cohort of 274 IBD patients intolerant for conventional therapies.
Melek Simsek, Debbie S Deben, Carmen S Horjus, Melanie V Bénard, Birgit I Lissenberg-Witte

Aliment Pharmacol Ther· July 2019

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Limited relevance and progression of histological alterations in the liver during thioguanine therapy in inflammatory bowel disease patients.
Dirk P van Asseldonk, Melek Simsek, Nanne K H de Boer, Bindia Jharap, Elisabeth Bloemena

Scand J Gastroenterol· June 2019

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Off-label prescriptions of drugs used for the treatment of Crohn's disease or ulcerative colitis.
Melek Simsek, Birgit I Lissenberg-Witte, Milou L M van Riswijk, Sander Verschuren, Frank Hoentjen

Aliment Pharmacol Ther· May 2019

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Clinical Course of Nodular Regenerative Hyperplasia in Thiopurine Treated Inflammatory Bowel Disease Patients.
Melek Simsek, Berrie Meijer, Dewkoemar Ramsoekh, Gerd Bouma, Egbert-Jan van der Wouden

Clin Gastroenterol Hepatol· February 2019

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Patient-Reported Experiences with a Relicensed Generic: Thioguanine for the Treatment of Inflammatory Bowel Diseases.
Melek Simsek, Tineke M L Markus-de Kwaadsteniet, Danielle van der Horst, Chris J J Mulder, Nanne K H de Boer

J Gastrointestin Liver Dis· December 2018

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Nodular regenerative hyperplasia in inflammatory bowel disease patients with allopurinol-thiopurine cotherapy.
Melek Simsek, Margien L Seinen, Nanne K H de Boer

Eur J Gastroenterol Hepatol· October 2018

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The teratogenicity of allopurinol: A comprehensive review of animal and human studies.
Melek Simsek, Roza C M Opperman, Chris J J Mulder, Cornelis B Lambalk, Nanne K H de Boer

Reprod Toxicol· October 2018

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The associations of thiopurines with male fertility and paternally exposed offspring: a systematic review and meta-analysis.
Melek Simsek, Cornelis B Lambalk, Janneke A Wilschut, Chris J J Mulder, Nanne K H de Boer

Hum Reprod Update· March 2018

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Paternal use of thiopurines and methotrexate: Are we reassured enough?
Melek Simsek, Nanne K H de Boer

Reprod Toxicol· January 2018

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