Publications by authors named "Meredith Calvert"

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Loss of PILRA promotes microglial immunometabolism to reduce amyloid pathology in cell and mouse models of Alzheimer's disease.
Tanya N Weerakkody, Hanna Sabelström, Shan V Andrews, Jean Paul Chadarevian, Marcus Y Chin, Meredith Calvert

Sci Transl Med· December 2025

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Dual targeting of transferrin receptor and CD98hc enhances brain exposure of large molecules.
Robert C Wells, Padma Akkapeddi, Darren Chan, David Joy, Arash Moshkforoush, Meredith E K Calvert

Cell Rep· August 2025

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Transferrin receptor-targeted anti-amyloid antibody enhances brain delivery and mitigates ARIA.
Michelle E Pizzo, Edward D Plowey, Nathalie Khoury, Wanda Kwan, Jordan Abettan, Meredith E Calvert

Science· August 2025

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Transferrin receptor-mediated transport at the blood-brain barrier is elevated during early development and maintained across aging and in an Alzheimer's mouse model.
Vanessa O Torres, Michelle E Pizzo, Darren Chan, Jason C Dugas, David Huynh, Meredith E Calvert

J Cereb Blood Flow Metab· August 2025

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Investigational eIF2B activator DNL343 modulates the integrated stress response in preclinical models of TDP-43 pathology and individuals with ALS in a randomized clinical trial.
Brittany N Flores, Seungyoon B Yu, Isaac V Cohen, Melania H Fanok, Wei Luan, Meredith E K Calvert

Nat Commun· August 2025

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Novel high-content and open-source image analysis tools for profiling mitochondrial morphology in neurological cell models.
Marcus Y Chin, David A Joy, Madhuja Samaddar, Anil Rana, Johann Chow, Meredith Calvert

SLAS Discov· March 2025

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Fc-engineered large molecules targeting blood-brain barrier transferrin receptor and CD98hc have distinct central nervous system and peripheral biodistribution.
Nathalie Khoury, Michelle E Pizzo, Claire B Discenza, David Joy, David Tatarakis, Meredith E K Calvert

Nat Commun· February 2025

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Decreased lipidated ApoE-receptor interactions confer protection against pathogenicity of ApoE and its lipid cargoes in lysosomes.
Jing L Guo, Dylan Braun, Gabriel A Fitzgerald, Yun-Ting Hsieh, Lionel Rougé, Meredith E K Calvert

Cell· January 2025

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Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Todd Logan, Matthew J Simon, Anil Rana, Gerald M Cherf, Ankita Srivastava, Meredith E K Calvert

Cell· March 2024

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SARM1 is responsible for calpain-dependent dendrite degeneration in mouse hippocampal neurons.
Takashi Miyamoto, Chaeyoung Kim, Johann Chow, Jason C Dugas, Jack DeGroot, Meredith Ek Calvert

J Biol Chem· February 2024

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Rab12 is a regulator of LRRK2 and its activation by damaged lysosomes.
Xiang Wang, Vitaliy V Bondar, Oliver B Davis, Michael T Maloney, Maayan Agam, Meredith E K Calvert

Elife· October 2023

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Author Correction: CD98hc is a target for brain delivery of biotherapeutics.
Kylie S Chew, Robert C Wells, Arash Moshkforoush, Darren Chan, Kendra J Lechtenberg, Meredith E K Calvert

Nat Commun· September 2023

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CD98hc is a target for brain delivery of biotherapeutics.
Kylie S Chew, Robert C Wells, Arash Moshkforoush, Darren Chan, Kendra J Lechtenberg, Meredith E K Calvert

Nat Commun· August 2023

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A TREM2-activating antibody with a blood-brain barrier transport vehicle enhances microglial metabolism in Alzheimer's disease models.
Bettina van Lengerich, Lihong Zhan, Dan Xia, Darren Chan, David Joy, Meredith Calvert

Nat Neurosci· March 2023

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Novel App knock-in mouse model shows key features of amyloid pathology and reveals profound metabolic dysregulation of microglia.
Dan Xia, Steve Lianoglou, Thomas Sandmann, Meredith Calvert, Jung H Suh

Mol Neurodegener· June 2022

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Molecular architecture determines brain delivery of a transferrin receptor-targeted lysosomal enzyme.
Annie Arguello, Cathal S Mahon, Meredith E K Calvert, Darren Chan, Jason C Dugas

J Exp Med· March 2022

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Rescue of a lysosomal storage disorder caused by Grn loss of function with a brain penetrant progranulin biologic.
Todd Logan, Matthew J Simon, Anil Rana, Gerald M Cherf, Ankita Srivastava, Meredith E K Calvert

Cell· September 2021

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Mitochondrial fission is a critical modulator of mutant APP-induced neural toxicity.
Lauren Y Shields, Huihui Li, Kevin Nguyen, Hwajin Kim, Zak Doric, Meredith Calvert

J Biol Chem· August 2021

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Imaging the developing human external and internal urogenital organs with light sheet fluorescence microscopy.
Dylan Isaacson, Dylan McCreedy, Meredith Calvert, Joel Shen, Adriane Sinclair

Differentiation· October 2020

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A molecular mechanism for probabilistic bet hedging and its role in viral latency.
Sonali Chaturvedi, Jonathan Klein, Noam Vardi, Cynthia Bolovan-Fritts, Marie Wolf, Meredith Calvert

Proc Natl Acad Sci U S A· July 2020

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Brain delivery of therapeutic proteins using an Fc fragment blood-brain barrier transport vehicle in mice and monkeys.
Mihalis S Kariolis, Robert C Wells, Jennifer A Getz, Wanda Kwan, Cathal S Mahon, Meredith E K Calvert

Sci Transl Med· May 2020

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Single-Cell Determination of Cardiac Microtissue Structure and Function Using Light Sheet Microscopy.
Diwakar Turaga, Oriane B Matthys, Tracy A Hookway, David A Joy, Meredith Calvert

Tissue Eng Part C Methods· April 2020

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A single H/ACA small nucleolar RNA mediates tumor suppression downstream of oncogenic RAS.
Mary McMahon, Adrian Contreras, Mikael Holm, Tamayo Uechi, Craig M Forester, Meredith E Calvert

Elife· September 2019

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Three-dimensional imaging of the developing human fetal urogenital-genital tract: Indifferent stage to male and female differentiation.
Dylan Isaacson, Joel Shen, Maya Overland, Yi Li, Adriane Sinclair, Meredith Calvert

Differentiation· June 2019

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Organic cation transporter 1 (OCT1) modulates multiple cardiometabolic traits through effects on hepatic thiamine content.
Xiaomin Liang, Sook Wah Yee, Huan-Chieh Chien, Eugene C Chen, Qi Luo, Meredith E Calvert

PLoS Biol· April 2018

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