Publications by authors named "Merlin Crossley"

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WDR5 serves in co-activation and influences genome targeting of KLF3.
Lu Yang, Manan Shah, Tanit Chavalit, Annalise M Spek, Wooi F Lim, Merlin Crossley

Nucleic Acids Res· September 2025

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Removal of promoter CpG methylation by epigenome editing reverses HBG silencing.
Henry W Bell, Ruopeng Feng, Manan Shah, Yu Yao, James Douglas, Merlin Crossley

Nat Commun· July 2025

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Hydroxyurea reduces the levels of the fetal gene repressors ZBTB7A/LRF and BCL11A in erythroid cells .
Gabriella E Martyn, Phillip A Doerfler, Yu Yao, Kate G R Quinlan, Mitchell J Weiss, Merlin Crossley

J Sick Cell Dis· October 2024

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Base editing of key residues in the BCL11A-XL-specific zinc finger domains derepresses fetal globin expression.
Vignesh Rajendiran, Nivedhitha Devaraju, Mahdi Haddad, Nithin Sam Ravi, Lokesh Panigrahi, Merlin Crossley

Mol Ther· March 2024

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miR-365-3p mediates BCL11A and SOX6 erythroid-specific coregulation: A new player in HbF activation.
Michela Simbula, Maria Francesca Manchinu, Maura Mingoia, Mauro Pala, Isadora Asunis, Merlin Crossley

Mol Ther Nucleic Acids· December 2023

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Author Correction: HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription.
Peng Huang, Scott A Peslak, Ren Ren, Eugene Khandros, Kunhua Qin, Merlin Crossley

Nat Genet· September 2023

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Potent and uniform fetal hemoglobin induction via base editing.
Thiyagaraj Mayuranathan, Gregory A Newby, Ruopeng Feng, Yu Yao, Kalin D Mayberry, Merlin Crossley

Nat Genet· July 2023

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Effective therapies for sickle cell disease: are we there yet?
Merlin Crossley, Georgios E Christakopoulos, Mitchell J Weiss

Trends Genet· December 2022

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Protocols for protein-DNA binding analysis of a zinc finger transcription factor bound to its cognate promoter.
Lana C Ly, Yang Yang, Fudong Li, Merlin Crossley, Yunyu Shi

STAR Protoc· September 2022

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HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription.
Peng Huang, Scott A Peslak, Ren Ren, Eugene Khandros, Kunhua Qin, Merlin Crossley

Nat Genet· September 2022

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Disrupting the adult globin promoter alleviates promoter competition and reactivates fetal globin gene expression.
Sarah K Topfer, Ruopeng Feng, Peng Huang, Lana C Ly, Gabriella E Martyn, Merlin Crossley

Blood· April 2022

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Identification of novel HPFH-like mutations by CRISPR base editing that elevate the expression of fetal hemoglobin.
Nithin Sam Ravi, Beeke Wienert, Stacia K Wyman, Henry William Bell, Anila George, Merlin Crossley

Elife· February 2022

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Structural basis for human ZBTB7A action at the fetal globin promoter.
Yang Yang, Ren Ren, Lana C Ly, John R Horton, Fudong Li, Merlin Crossley

Cell Rep· September 2021

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Activation of γ-globin gene expression by GATA1 and NF-Y in hereditary persistence of fetal hemoglobin.
Phillip A Doerfler, Ruopeng Feng, Yichao Li, Lance E Palmer, Shaina N Porter, Merlin Crossley

Nat Genet· August 2021

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ZNF410 Uniquely Activates the NuRD Component CHD4 to Silence Fetal Hemoglobin Expression.
Xianjiang Lan, Ren Ren, Ruopeng Feng, Lana C Ly, Yemin Lan, Merlin Crossley

Mol Cell· January 2021

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Global citizen deliberation on genome editing.
John S Dryzek, Dianne Nicol, Simon Niemeyer, Sonya Pemberton, Nicole Curato, Merlin Crossley

Science· September 2020

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Eosinophil function in adipose tissue is regulated by Krüppel-like factor 3 (KLF3).
Alexander J Knights, Emily J Vohralik, Peter J Houweling, Elizabeth S Stout, Laura J Norton, Merlin Crossley

Nat Commun· June 2020

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Krüppel-like factor 3 (KLF3) suppresses NF-κB-driven inflammation in mice.
Alexander J Knights, Lu Yang, Manan Shah, Laura J Norton, Gamran S Green, Merlin Crossley

J Biol Chem· May 2020

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Methylation of a CGATA element inhibits binding and regulation by GATA-1.
Lu Yang, Zhiliang Chen, Elizabeth S Stout, Fabien Delerue, Lars M Ittner, Merlin Crossley

Nat Commun· May 2020

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Hit and Run Transcriptional Repressors Are Difficult to Catch in the Act.
Manan Shah, Alister P W Funnell, Kate G R Quinlan, Merlin Crossley

Bioessays· August 2019

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A natural regulatory mutation in the proximal promoter elevates fetal expression by creating a de novo GATA1 site.
Gabriella E Martyn, Beeke Wienert, Ryo Kurita, Yukio Nakamura, Kate G R Quinlan, Merlin Crossley

Blood· February 2019

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Wake-up Sleepy Gene: Reactivating Fetal Globin for β-Hemoglobinopathies.
Beeke Wienert, Gabriella E Martyn, Alister P W Funnell, Kate G R Quinlan, Merlin Crossley

Trends Genet· December 2018

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Partial reprogramming of heterologous cells by defined factors to generate megakaryocyte lineage-restricted biomolecules.
Crisbel M Artuz, Alexander J Knights, Alister P W Funnell, Thomas J Gonda, Katya Ravid, Merlin Crossley

Biotechnol Rep (Amst)· December 2018

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Charting a noncoding gene for γ-globin activation.
Gerd A Blobel, Merlin Crossley

Blood· November 2018

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Defining Eosinophil Function in Adiposity and Weight Loss.
Alexander J Knights, Emily J Vohralik, Kyle L Hoehn, Merlin Crossley, Kate G R Quinlan

Bioessays· October 2018

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