Publications by authors named "Meru Sadhu"

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Improved vectors for retron-mediated CRISPR-Cas9 genome editing in Saccharomyces cerevisiae.
Tara N Stuecker, Stephanie E Hood, Julio Molina Pineda, Sonali Lenaduwe, Joshua Winter, Meru J Sadhu

G3 (Bethesda)· October 2025

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Highly replicated experiments studying complex genotypes using nested DNA barcodes.
Molly Monge, Simone M Giovanetti, Apoorva Ravishankar, Meru J Sadhu

G3 (Bethesda)· September 2025

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Killer toxin K28 resistance in yeast relies on COG complex-mediated trafficking of the defence factor Ktd1.
Kamilla M E Laidlaw, Hatwan H Nadir, Amy Milburn, Martha S C Xelhuantzi, Justas Stanislovas, Meru J Sadhu

J Cell Sci· July 2025

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Highly replicated experiments studying complex genotypes using nested DNA barcodes.
Molly Monge, Simone M Giovanetti, Apoorva Ravishankar, Meru J Sadhu

bioRxiv· March 2025

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Systematic genetic characterization of the human PKR kinase domain highlights its functional malleability to escape a poxvirus substrate mimic.
Michael James Chambers, Sophia B Scobell, Meru J Sadhu

Elife· November 2024

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Comprehensive deletion scan of anti-CRISPR AcrIIA4 reveals essential and dispensable domains for Cas9 inhibition.
Annette B Iturralde, Cory A Weller, Simone M Giovanetti, Meru J Sadhu

Proc Natl Acad Sci U S A· November 2024

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Systematic genetic characterization of the human PKR kinase domain highlights its functional malleability to escape a poxvirus substrate mimic.
Michael J Chambers, Sophia B Scobell, Meru J Sadhu

bioRxiv· September 2024

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Improved vectors for retron-mediated CRISPR-Cas9 genome editing in .
Tara N Stuecker, Stephanie E Hood, Julio Molina Pineda, Sonali Lenaduwe, Joshua Winter, Meru J Sadhu

bioRxiv· August 2024

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Comprehensive deletion scan of anti-CRISPR AcrIIA4 reveals essential and dispensable domains for Cas9 inhibition.
Annette B Iturralde, Cory A Weller, Meru J Sadhu

bioRxiv· July 2024

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Systematic characterization of the local evolutionary space available to human PKR and vaccinia virus K3.
Michael J Chambers, Sophia Scobell, Meru J Sadhu

bioRxiv· November 2023

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Highly complete long-read genomes reveal pangenomic variation underlying yeast phenotypic diversity.
Cory A Weller, Ilya Andreev, Michael J Chambers, Morgan Park, , Meru J Sadhu

Genome Res· May 2023

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Discovery of a rapidly evolving yeast defense factor, , against the secreted killer toxin K28.
Ilya Andreev, Kamilla M E Laidlaw, Simone M Giovanetti, Guillaume Urtecho, Daniel Shriner, Meru J Sadhu

Proc Natl Acad Sci U S A· February 2023

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Genome-wide base editor screen identifies regulators of protein abundance in yeast.
Olga T Schubert, Joshua S Bloom, Meru J Sadhu, Leonid Kruglyak

Elife· November 2022

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Ancient balancing selection maintains incompatible versions of the galactose pathway in yeast.
James Boocock, Meru J Sadhu, Arun Durvasula, Joshua S Bloom, Leonid Kruglyak

Science· January 2021

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Rare variants contribute disproportionately to quantitative trait variation in yeast.
Joshua S Bloom, James Boocock, Sebastian Treusch, Meru J Sadhu, Laura Day

Elife· October 2019

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Analysis of the genetic basis of height in large Jewish nuclear families.
Danny Zeevi, Joshua S Bloom, Meru J Sadhu, Adi Ben Yehuda, David Zangen

PLoS Genet· July 2019

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How Low Can You Go?
Meru J Sadhu, Leonid Kruglyak

CRISPR J· October 2018

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Highly parallel genome variant engineering with CRISPR-Cas9.
Meru J Sadhu, Joshua S Bloom, Laura Day, Jake J Siegel, Sriram Kosuri

Nat Genet· April 2018

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Accounting for genetic interactions improves modeling of individual quantitative trait phenotypes in yeast.
Simon K G Forsberg, Joshua S Bloom, Meru J Sadhu, Leonid Kruglyak, Örjan Carlborg

Nat Genet· April 2017

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CRISPR-directed mitotic recombination enables genetic mapping without crosses.
Meru J Sadhu, Joshua S Bloom, Laura Day, Leonid Kruglyak

Science· May 2016

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Genetic interactions contribute less than additive effects to quantitative trait variation in yeast.
Joshua S Bloom, Iulia Kotenko, Meru J Sadhu, Sebastian Treusch, Frank W Albert

Nat Commun· November 2015

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Multiple inputs control sulfur-containing amino acid synthesis in Saccharomyces cerevisiae.
Meru J Sadhu, James J Moresco, Anjali D Zimmer, John R Yates, Jasper Rine

Mol Biol Cell· May 2014

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Nutritional control of epigenetic processes in yeast and human cells.
Meru J Sadhu, Qiaoning Guan, Fei Li, Jade Sales-Lee, Anthony T Iavarone

Genetics· November 2013

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Evolutionary analysis of heterochromatin protein compatibility by interspecies complementation in Saccharomyces.
Oliver A Zill, Devin R Scannell, Jeffrey Kuei, Meru Sadhu, Jasper Rine

Genetics· November 2012

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Identification of genes regulating sensory neuron genesis and differentiation in the avian dorsal root ganglia.
Branden R Nelson, Meru Sadhu, Jennifer C Kasemeier, Lawrence W Anderson, Frances Lefcort

Dev Dyn· March 2004

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