Publications by authors named "Mesut Isik"

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Design, Synthesis, In Silico Absorption, Distribution, Metabolism, and Elimination and Molecular Docking Studies of Thiazole-Based Furan Derivatives, and Their Biological Evaluation for Alzheimer Disease Therapy.
Abdüllatif Karakaya, Ulviye Acar Çevik, Betül Kaya, Bilge Çiftçi, Adem Necip

ChemistryOpen· December 2025

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Design, Synthesis, and Molecular Docking Studies of Novel Pyrazoline-Thiazoles as Cholinesterase Dual-Target Inhibitors for the Treatment of Alzheimer's Disease.
Betül Kaya, Ulviye Acar Çevik, Bilge Çiftçi, Adem Necip, Mesut Işik

ACS Omega· September 2025

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Phytochemical Compositions and Bioactive Properties of Plantago lanceolata L.: Anti-oxidant, Anti-diabetic, and Anti-cholinergic Potentials.
Mesut Işık, Emrullah Sümer

J Oleo Sci· August 2025

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Imidazolium salts carrying two positive charges: design, synthesis, characterization, molecular docking, antibacterial and enzyme inhibitory activities.
Ilter Demirhan, Adem Necip, Erkan Oner, Nalin Gumuscu, Ozlem Demirci

Front Cell Infect Microbiol· August 2025

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Potential Inflammatory Mediators in Pericardial Fluids of Patients With Coronary Artery Diseases and Their Association With Plasma Biomarkers.
Reşat Dikme, Mehmet Salih Aydın, Ebru Temiz, İsmail Koyuncu, Mesut Işık

J Cell Mol Med· June 2025

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Phenolic Content, Antioxidant Capacity, and Therapeutic Potential of Mango ( L.) Leaves.
Mesut Işık, Emrah Dikici, Sevgi Altın, Cemalettin Alp, Kevser Kübra Kırboğa

Food Sci Nutr· May 2025

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Design, Synthesis, Biological Evaluation, and Molecular Docking Studies of Novel 1,3,4-Thiadiazole Derivatives Targeting Both Aldose Reductase and α-Glucosidase for Diabetes Mellitus.
Betül Kaya, Ulviye Acar Çevik, Adem Necip, Hatice Esra Duran, Bilge Çiftçi

ACS Omega· May 2025

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Sulfonamide-Bearing Pyrazolone Derivatives as Multitarget Therapeutic Agents: Design, Synthesis, Characterization, Biological Evaluation, In Silico ADME/T Profiling and Molecular Docking Study.
Nebih Lolak, Suleyman Akocak, Meryem Topal, Ümit Muhammet Koçyiğit, Mesut Işık

Pharmacol Res Perspect· April 2025

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Discovery of Hydrazine Clubbed Thiazoles as Potential Antidiabetic Agents: Synthesis, Biological Evaluation, and Molecular Docking Studies.
Betül Kaya, Hakan Tahtacı, Bilge Çiftçi, Hatice Esra Duran, Adem Necip

Drug Dev Res· February 2025

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Therapeutic potential of extract by experimental and computational approaches: phenolic content and bioactivities for antioxidant, antidiabetic, and anticholinergic properties.
Sevgi Altın, Mesut Işık, Cemalettin Alp, Emrah Dikici, Ekrem Köksal

Front Chem· February 2025

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Interactions of novel 1,3-diaryltriazene-sulfamethazines with carbonic anhydrases: Kinetic studies and in silico simulations.
Nabih Lolak, Cüneyt Türkeş, Suleyman Akocak, Hatice Esra Duran, Mesut Işık

Arch Biochem Biophys· November 2024

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Synthesis, α-Glucosidase, α-Amylase, and Aldol Reductase Inhibitory Activity with Molecular Docking Study of Novel Imidazo[1,2-]pyridine Derivatives.
Betül Kaya, Ulviye Acar Çevik, Bilge Çiftçi, Hatice Esra Duran, Cüneyt Türkeş

ACS Omega· October 2024

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Dynamics of small molecule-enzyme interactions: Novel benzenesulfonamides as multi-target agents endowed with inhibitory effects against some metabolic enzymes.
Özcan Güleç, Cüneyt Türkeş, Mustafa Arslan, Mesut Işık, Yeliz Demir

Arch Biochem Biophys· September 2024

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Frequency of Post Traumatic Stress Disorder and Associated Factors Among Survivors of Van Avalanche: 6-Month Follow-up Study.
Faruk Kurhan, Gülsüm Zuhal Kamiş, Dilem Dinç, İshak Tekin, Mesut Işik

Turk Psikiyatri Derg· September 2024

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Explainable artificial intelligence in the design of selective carbonic anhydrase I-II inhibitors via molecular fingerprinting.
Kevser Kübra Kırboğa, Mesut Işık

J Comput Chem· July 2024

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Antioxidant, antidiabetic effects and polyphenolic contents of propolis from Siirt, Turkey.
Eda Ören, Salih Tuncay, Yunus Emre Toprak, Muhammet Fırat, İsra Toptancı

Food Sci Nutr· April 2024

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Isolation of phenolic compounds from eco-friendly white bee propolis: Antioxidant, wound-healing, and anti-Alzheimer effects.
Adem Necip, Ibrahim Demirtas, Seçil Erden Tayhan, Mesut Işık, Sema Bilgin

Food Sci Nutr· March 2024

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Design and Synthesis of Pyrazole Carboxamide Derivatives as Selective Cholinesterase and Carbonic Anhydrase Inhibitors: Molecular Docking and Biological Evaluation.
Mustafa Durgun, Suleyman Akocak, Nebih Lolak, Fevzi Topal, Ümit Muhammet Koçyiğit

Chem Biodivers· February 2024

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Effect of fentanyl and remifentanil on neuron damage and oxidative stress during induction neurotoxicity.
Ali Taghizadehghalehjoughi, Muhammet Emin Naldan, Yesim Yeni, Sidika Genc, Ahmet Hacimuftuoglu, Mesut Isik

J Cell Mol Med· February 2024

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Phenolic Content Analysis of Two Species Belonging to the Family: Antioxidant, Anticholinergic, and Antibacterial Activities.
Ashwell R Ndhlala, Mesut Işık, Arzu Kavaz Yüksel, Emrah Dikici

Molecules· January 2024

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Evaluation of the relationship among gene expressions and enzyme activities with antioxidant role and presenilin 1 expression in Alzheimer's disease.
Mesut Işık, Abdullah Tunç, Hatice Esra Duran, Muhammet Emin Naldan, Aslan Yılmaz

J Cell Mol Med· November 2023

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Paramagnetic characterization of fossil mollusc shells at eastern part of the old Konya lake: its importance for EPR dating.
Gamze Ekici, Ulku Sayin, Mesut Isik, Sevinc Kapan, Ahmet Demir

Radiat Prot Dosimetry· September 2023

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Novel bis-ureido-substituted sulfaguanidines and sulfisoxazoles as carbonic anhydrase and acetylcholinesterase inhibitors.
Nebih Lolak, Süleyman Akocak, Mustafa Durgun, Hatice Esra Duran, Adem Necip

Mol Divers· August 2023

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Synthesis and Characterization of Novel 1,3-Diaryltriazene-Substituted Sulfaguanidine Derivatives as Selective Carbonic Anhydrase Inhibitors: Biological Evaluation, in Silico ADME/T and Molecular Docking Study.
Suleyman Akocak, Nebih Lolak, Hatice Esra Duran, Mesut Işık, Cüneyt Türkeş

Chem Biodivers· August 2023

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CVD22: Explainable artificial intelligence determination of the relationship of troponin to D-Dimer, mortality, and CK-MB in COVID-19 patients.
Kevser Kübra Kırboğa, Ecir Uğur Küçüksille, Muhammet Emin Naldan, Mesut Işık, Oktay Gülcü

Comput Methods Programs Biomed· May 2023

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