Publications by authors named "Michael A Dengler"

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Metabolic adaptation of glucose-deprived macrophages involves partial gluconeogenesis.
Katharina Schindlmaier, Theresa Haitzmann, Visnja Bubalo, Barbara Konrad, Joseph Jelwan, Michael A Dengler

Proc Natl Acad Sci U S A· November 2025

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Lymphotoxin alpha eradicates acute myeloid leukemia and simultaneously promotes healthy hematopoiesis in mice.
Ulrike Höckendorf, Sayantanee Dutta, Arnold Kloos, Marah Runtsch, Carina Zötsch, Michael A Dengler

Sci Transl Med· November 2025

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Acquired mutations in BAX confer resistance to BH3-mimetic therapy in acute myeloid leukemia.
Donia M Moujalled, Fiona C Brown, Chong Chyn Chua, Michael A Dengler, Giovanna Pomilio

Blood· February 2023

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Non-coding RNAs and ferroptosis: potential implications for cancer therapy.
Amar Balihodzic, Felix Prinz, Michael A Dengler, George A Calin, Philipp J Jost

Cell Death Differ· June 2022

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Clonal hematopoiesis, myeloid disorders and BAX-mutated myelopoiesis in patients receiving venetoclax for CLL.
Piers Blombery, Thomas E Lew, Michael A Dengler, Ella R Thompson, Victor S Lin

Blood· February 2022

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The BCL-2 family member BOK promotes KRAS-driven lung cancer progression in a p53-dependent manner.
Anna-Lena Meinhardt, Enkhtsetseg Munkhbaatar, Ulrike Höckendorf, Michelle Dietzen, Marta Dechant, Michael A Dengler

Oncogene· February 2022

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BAX mitochondrial integration is regulated allosterically by its α1-α2 loop.
Michael A Dengler, Leonie Gibson, Jerry M Adams

Cell Death Differ· December 2021

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Intact TP-53 function is essential for sustaining durable responses to BH3-mimetic drugs in leukemias.
Rachel Thijssen, Sarah T Diepstraten, Donia Moujalled, Edward Chew, Christoffer Flensburg, Michael A Dengler

Blood· May 2021

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Nanobody cocktails potently neutralize SARS-CoV-2 D614G N501Y variant and protect mice.
Phillip Pymm, Amy Adair, Li-Jin Chan, James P Cooney, Francesca L Mordant, Michael A Dengler

Proc Natl Acad Sci U S A· May 2021

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Flexible Usage and Interconnectivity of Diverse Cell Death Pathways Protect against Intracellular Infection.
Marcel Doerflinger, Yexuan Deng, Paul Whitney, Ranja Salvamoser, Sven Engel, Michael A Dengler

Immunity· September 2020

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Robust autoactivation for apoptosis by BAK but not BAX highlights BAK as an important therapeutic target.
Sweta Iyer, Rachel T Uren, Michael A Dengler, Melissa X Shi, Etsuko Uno

Cell Death Dis· April 2020

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Characterization of a novel human BFL-1-specific monoclonal antibody.
Lahiru Gangoda, Charis E Teh, Michael A Dengler, Sarah A Best, Clare E Weeden

Cell Death Differ· February 2020

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Potent efficacy of MCL-1 inhibitor-based therapies in preclinical models of mantle cell lymphoma.
Michael A Dengler, Charis E Teh, Rachel Thijssen, Lahiru Gangoda, Ping Lan

Oncogene· February 2020

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BAX Activation: Mutations Near Its Proposed Non-canonical BH3 Binding Site Reveal Allosteric Changes Controlling Mitochondrial Association.
Michael A Dengler, Adeline Y Robin, Leonie Gibson, Mark X Li, Jarrod J Sandow

Cell Rep· April 2019

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Subtle Changes in the Levels of BCL-2 Proteins Cause Severe Craniofacial Abnormalities.
Stephanie Grabow, Andrew J Kueh, Francine Ke, Hannah K Vanyai, Bilal N Sheikh, Michael A Dengler

Cell Rep· September 2018

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An analysis of the role of follicular lymphoma-associated fibroblasts to promote tumor cell viability following drug-induced apoptosis.
Annette M Staiger, Jasmin Duppel, Michael A Dengler, Heiko van der Kuip, Matthias C Vöhringer

Leuk Lymphoma· August 2017

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BAK α6 permits activation by BH3-only proteins and homooligomerization via the canonical hydrophobic groove.
Mark Xiang Li, Iris K L Tan, Stephen B Ma, Colin Hockings, Tobias Kratina, Michael A Dengler

Proc Natl Acad Sci U S A· July 2017

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Cisplatin hypersensitivity of testicular germ cell tumors is determined by high constitutive Noxa levels mediated by Oct-4.
Matthias Gutekunst, Thomas Mueller, Andrea Weilbacher, Michael A Dengler, Jens Bedke

Cancer Res· March 2013

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Imaging of myocardial infarction using ultrasmall superparamagnetic iron oxide nanoparticles: a human study using a multi-parametric cardiovascular magnetic resonance imaging approach.
Ali Yilmaz, Michael A Dengler, Heiko van der Kuip, Handan Yildiz, Sabine Rösch

Eur Heart J· February 2013

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Oncogenic stress induced by acute hyper-activation of Bcr-Abl leads to cell death upon induction of excessive aerobic glycolysis.
Michael A Dengler, Annette M Staiger, Matthias Gutekunst, Ute Hofmann, Malgorzata Doszczak

PLoS One· February 2012

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p53 hypersensitivity is the predominant mechanism of the unique responsiveness of testicular germ cell tumor (TGCT) cells to cisplatin.
Matthias Gutekunst, Moshe Oren, Andrea Weilbacher, Michael A Dengler, Christiane Markwardt

PLoS One· April 2011

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