Publications by authors named "Michael A Kalwat"

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Unique and conserved endoplasmic reticulum stress responses in neuroendocrine cells.
Karina Rodrigues-Dos-Santos, Gitanjali Roy, Anna Geisinger, Sahiti Somalraju, Travis S Johnson, Michael A Kalwat

bioRxiv· September 2025

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Identification of type 2 diabetes- and obesity-associated human β-cells using deep transfer learning.
Gitanjali Roy, Rameesha Syed, Olivia Lazaro, Sylvia Robertson, Sean D McCabe, Michael A Kalwat

Elife· September 2025

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Unique and Conserved Endoplasmic Reticulum Stress Responses in Neuroendocrine Cells.
Karina Rodrigues-Dos-Santos, Gitanjali Roy, Anna Geisinger, Sahiti Somalraju, Travis S Johnson, Michael A Kalwat

Cells· September 2025

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Identification of High-Risk Cells in Single-Cell Spatially Resolved Transcriptomics Data Using DEGAS Spatial Smoothing.
Debolina Chatterjee, Justin L Couetil, Ziyu Liu, Kun Huang, Chao Chen, Michael A Kalwat

bioRxiv· August 2025

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Identification of type 2 diabetes- and obesity-associated human β-cells using deep transfer learning.
Gitanjali Roy, Rameesha Syed, Olivia Lazaro, Sylvia Robertson, Sean D McCabe, Michael A Kalwat

bioRxiv· July 2025

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VDAC1 is a target for pharmacologically induced insulin hypersecretion in β cells.
Gitanjali Roy, Andrea Ordóñez, Derk D Binns, Karina Rodrigues-Dos-Santos, Michael B Kwakye, Michael A Kalwat

Cell Rep· June 2025

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Target deconvolution of an insulin hypersecretion-inducer acting through VDAC1 with a distinct transcriptomic signature in beta-cells.
Gitanjali Roy, Andrea Ordóñez, Derk D Binns, Karina Rodrigues Dos Santos, Michael B Kwakye, Michael A Kalwat

bioRxiv· December 2024

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RIPK3 promotes islet amyloid-induced β-cell loss and glucose intolerance in a humanized mouse model of type 2 diabetes.
Noyonika Mukherjee, Christopher J Contreras, Li Lin, Kaitlyn A Colglazier, Egan G Mather, Michael A Kalwat

Mol Metab· February 2024

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Small molecule glucagon release inhibitors with activity in human islets.
Michael A Kalwat, Karina Rodrigues-Dos-Santos, Derk D Binns, Shuguang Wei, Anwu Zhou

Front Endocrinol (Lausanne)· May 2023

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Therapeutic Strategies Targeting Pancreatic Islet β-Cell Proliferation, Regeneration, and Replacement.
Roy A Goode, Julia M Hum, Michael A Kalwat

Endocrinology· November 2022

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Small Molecule-mediated Insulin Hypersecretion Induces Transient ER Stress Response and Loss of Beta Cell Function.
Karina Rodrigues-Dos-Santos, Gitanjali Roy, Derk D Binns, Magdalena G Grzemska, Luiz F Barella, Michael A Kalwat

Endocrinology· July 2022

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The Pancreatic ß-cell Response to Secretory Demands and Adaption to Stress.
Michael A Kalwat, Donalyn Scheuner, Karina Rodrigues-Dos-Santos, Decio L Eizirik, Melanie H Cobb

Endocrinology· November 2021

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High-Throughput Screening for Insulin Secretion Modulators.
Michael A Kalwat

Methods Mol Biol· March 2021

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Correction to: High-Throughput Screening for Insulin Secretion Modulators.
Michael A Kalwat

Methods Mol Biol· January 2021

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α-Adrenergic Disruption of β Cell BDNF-TrkB Receptor Tyrosine Kinase Signaling.
Michael A Kalwat, Zhimin Huang, Derk D Binns, Kathleen McGlynn, Melanie H Cobb

Front Cell Dev Biol· October 2020

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Pancreatitis is an FGF21-deficient state that is corrected by replacement therapy.
Genaro Hernandez, Ting Luo, Tanveer A Javed, Li Wen, Michael A Kalwat

Sci Transl Med· January 2020

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Chromomycin A potently inhibits glucose-stimulated insulin secretion from pancreatic β cells.
Michael A Kalwat, In Hyun Hwang, Jocelyn Macho, Magdalena G Grzemska, Jonathan Z Yang

J Gen Physiol· December 2018

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Mechanisms of the amplifying pathway of insulin secretion in the β cell.
Michael A Kalwat, Melanie H Cobb

Pharmacol Ther· November 2017

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Sucralose activates an ERK1/2-ribosomal protein S6 signaling axis.
Marcy L Guerra, Michael A Kalwat, Kathleen McGlynn, Melanie H Cobb

FEBS Open Bio· February 2017

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Correction to Insulin Promoter-Driven Gaussia Luciferase-Based Insulin Secretion Biosensor Assay for Discovery of β-Cell Glucose-Sensing Pathways.
Michael A Kalwat, Chonlarat Wichaidit, Alejandra Y Nava Garcia, Melissa K McCoy, Kathleen McGlynn

ACS Sens· February 2017

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Insulin promoter-driven Gaussia luciferase-based insulin secretion biosensor assay for discovery of β-cell glucose-sensing pathways.
Michael A Kalwat, Chonlarat Wichaidit, Alejandra Y Nava Garcia, Melissa K McCoy, Kathleen McGlynn

ACS Sens· October 2016

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Isoxazole Alters Metabolites and Gene Expression, Decreasing Proliferation and Promoting a Neuroendocrine Phenotype in β-Cells.
Michael A Kalwat, Zhimin Huang, Chonlarat Wichaidit, Kathleen McGlynn, Svetlana Earnest

ACS Chem Biol· April 2016

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Signaling mechanisms of glucose-induced F-actin remodeling in pancreatic islet β cells.
Michael A Kalwat, Debbie C Thurmond

Exp Mol Med· August 2013

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A p21-activated kinase (PAK1) signaling cascade coordinately regulates F-actin remodeling and insulin granule exocytosis in pancreatic β cells.
Michael A Kalwat, Stephanie M Yoder, Zhanxiang Wang, Debbie C Thurmond

Biochem Pharmacol· March 2013

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Doc2b is a key effector of insulin secretion and skeletal muscle insulin sensitivity.
Latha Ramalingam, Eunjin Oh, Stephanie M Yoder, Joseph T Brozinick, Michael A Kalwat

Diabetes· October 2012

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