Publications by authors named "Michael A Rogawski"

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ENX-101, a GABA receptor α2,3,5-selective positive allosteric modulator, displays antiseizure effects in rodent seizure and epilepsy models.
Jordi Serrats, Krishna C Vadodaria, William Brubaker, Melissa Barker-Haliski, H Steve White, Michael A Rogawski

Epilepsia· June 2025

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Interim analysis of the long-term efficacy and safety of azetukalner in an ongoing open-label extension study following a phase 2b clinical trial (X-TOLE) in adults with focal epilepsy.
Jacqueline A French, Roger J Porter, Emilio Perucca, Martin J Brodie, Michael A Rogawski

Epilepsia Open· April 2025

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Allopregnanolone as an Adjunct Therapy to Midazolam is More Effective Than Midazolam Alone in Suppressing Soman-Induced Status Epilepticus in Male Rats.
Peter M Andrew, Jeremy A MacMahon, Xiuzhen Liu, Naomi H Saito, Kyle E Berger, Michael A Rogawski

CNS Neurosci Ther· March 2025

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Efficacy and Safety of XEN1101, a Novel Potassium Channel Opener, in Adults With Focal Epilepsy: A Phase 2b Randomized Clinical Trial.
Jacqueline A French, Roger J Porter, Emilio Perucca, Martin J Brodie, Michael A Rogawski

JAMA Neurol· November 2023

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Tolerability and pharmacokinetics of intravenous allopregnanolone with and without midazolam pretreatment in two healthy dogs.
Donald A Bruun, Betty Ma, Yi-Je Chen, Chun-Yi Wu, Monica Aleman, Michael A Rogawski

Epilepsia Open· June 2023

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A randomized, open-label, two-treatment crossover study to evaluate the effect of food on the pharmacokinetics of diazepam nasal spray in healthy adults.
Michael A Rogawski, Gary Slatko

Epilepsia· February 2023

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Intravenous and Intramuscular Allopregnanolone for Early Treatment of Status Epilepticus: Pharmacokinetics, Pharmacodynamics, and Safety in Dogs.
Irene Vuu, Edward E Patterson, Chun-Yi Wu, Dorota Zolkowska, Ilo E Leppik, Michael A Rogawski

J Pharmacol Exp Ther· February 2022

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Strain differences in the extent of brain injury in mice after tetramethylenedisulfotetramine-induced status epilepticus.
Jonas J Calsbeek, Eduardo A González, Casey A Boosalis, Dorota Zolkowska, Donald A Bruun, Michael A Rogawski

Neurotoxicology· December 2021

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Cortical excitability threshold can be increased by the AMPA blocker Perampanel in amyotrophic lateral sclerosis.
Björn Oskarsson, Elizabeth A Mauricio, Jaimin S Shah, Zhuo Li, Michael A Rogawski

Muscle Nerve· August 2021

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Perampanel, a potent AMPA receptor antagonist, protects against tetramethylenedisulfotetramine-induced seizures and lethality in mice: comparison with diazepam.
Dorota Zolkowska, Ashish Dhir, Michael A Rogawski

Arch Toxicol· July 2021

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Intranasal Allopregnanolone Confers Rapid Seizure Protection: Evidence for Direct Nose-to-Brain Delivery.
Dorota Zolkowska, Chun-Yi Wu, Michael A Rogawski

Neurotherapeutics· January 2021

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Safety, tolerability, and pharmacokinetics of allopregnanolone as a regenerative therapeutic for Alzheimer's disease: A single and multiple ascending dose phase 1b/2a clinical trial.
Gerson D Hernandez, Christine M Solinsky, Wendy J Mack, Naoko Kono, Kathleen E Rodgers, Michael A Rogawski

Alzheimers Dement (N Y)· December 2020

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Allopregnanolone and perampanel as adjuncts to midazolam for treating diisopropylfluorophosphate-induced status epilepticus in rats.
Ashish Dhir, Donald A Bruun, Michelle Guignet, Yi-Hua Tsai, Eduardo González, Michael A Rogawski

Ann N Y Acad Sci· November 2020

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The chemical convulsant diisopropylfluorophosphate (DFP) causes persistent neuropathology in adult male rats independent of seizure activity.
Eduardo A González, Alexa C Rindy, Michelle A Guignet, Jonas J Calsbeek, Donald A Bruun, Michael A Rogawski

Arch Toxicol· June 2020

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Mechanisms of action of currently used antiseizure drugs.
Graeme J Sills, Michael A Rogawski

Neuropharmacology· May 2020

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Reduced efficacy and risk of seizure aggravation when cannabidiol is used without clobazam.
Michael A Rogawski

Epilepsy Behav· February 2020

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Persistent behavior deficits, neuroinflammation, and oxidative stress in a rat model of acute organophosphate intoxication.
Michelle Guignet, Kiran Dhakal, Brenna M Flannery, Brad A Hobson, Dorota Zolkowska, Michael A Rogawski

Neurobiol Dis· January 2020

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Epilepsy Benchmarks Area III: Improved Treatment Options for Controlling Seizures and Epilepsy-Related Conditions Without Side Effects.
Stephen F Traynelis, Dennis Dlugos, David Henshall, Heather C Mefford, Michael A Rogawski

Epilepsy Curr· January 2020

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Diazepam buccal film for the treatment of acute seizures.
Michael A Rogawski, Allen H Heller

Epilepsy Behav· December 2019

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Blood-brain barrier dysfunction in aging induces hyperactivation of TGFβ signaling and chronic yet reversible neural dysfunction.
Vladimir V Senatorov, Aaron R Friedman, Dan Z Milikovsky, Jonathan Ofer, Rotem Saar-Ashkenazy, Michael A Rogawski

Sci Transl Med· December 2019

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Intramuscular allopregnanolone and ganaxolone in a mouse model of treatment-resistant status epilepticus.
Dorota Zolkowska, Chun-Yi Wu, Michael A Rogawski

Epilepsia· October 2018

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Determination of minimal steady-state plasma level of diazepam causing seizure threshold elevation in rats.
Ashish Dhir, Michael A Rogawski

Epilepsia· May 2018

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Defective GABAergic neurotransmission in the nucleus tractus solitarius in Mecp2-null mice, a model of Rett syndrome.
Chao-Yin Chen, Jacopo Di Lucente, Yen-Chu Lin, Cheng-Chang Lien, Michael A Rogawski

Neurobiol Dis· January 2018

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Commonalities in epileptogenic processes from different acute brain insults: Do they translate?
Pavel Klein, Raymond Dingledine, Eleonora Aronica, Christophe Bernard, Ingmar Blümcke, Michael A Rogawski

Epilepsia· January 2018

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