Publications by authors named "Michael A Stashko"

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Fluorinated pyrimidine 5-carboxamides as potential tools for MERTK targeted fluorine-18-PET-radioligand development.
Ramesh Mudududdla, Siu Wai Wong, Nghi Nguyen, Lian Xue, Michael A Stashko

RSC Med Chem· December 2025

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Design, Synthesis, and Cellular Characterization of a New Class of IPMK Kinase Inhibitors.
Yubai Zhou, Pratima Chapagain, Desmarini Desmarini, Dilipkumar Uredi, Michael A Stashko

J Med Chem· August 2025

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Exploiting structural variability in the kinase back-pocket to modulate polypharmacology of TAM inhibitors.
Megan D Hopkins, Dehui Zhang, Zhilong Chen, Andrew L McIver, Justus M Huelse, Michael A Stashko

Eur J Med Chem· June 2025

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Discovery of Novel TYRO3/MERTK Dual Inhibitors.
Deyu Kong, Jichen Zhao, Daowei Huang, Michael A Stashko, Dan Yan

J Med Chem· April 2025

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UNC9426, a Potent and Orally Bioavailable TYRO3-Specific Inhibitor.
Deyu Kong, Xiangbo Yang, Samantha Judd, Dan Yan, Stephanie Springborn, Michael A Stashko

J Med Chem· March 2025

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Potent and selective SETDB1 covalent negative allosteric modulator reduces methyltransferase activity in cells.
Mélanie Uguen, Devan J Shell, Madhushika Silva, Yu Deng, Fengling Li, Michael A Stashko

Nat Commun· February 2025

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Identification of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach.
Eric M Merten, John D Sears, Tina M Leisner, P Brian Hardy, Anirban Ghoshal, Michael A Stashko

Proc Natl Acad Sci U S A· October 2024

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Potent and Selective SETDB1 Covalent Negative Allosteric Modulator Reduces Methyltransferase Activity in Cells.
Mélanie Uguen, Devan J Shell, Madhushika Silva, Yu Deng, Fengling Li, Michael A Stashko

bioRxiv· September 2024

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Discovery of a cell-active chikungunya virus nsP2 protease inhibitor using a covalent fragment-based screening approach.
Eric M Merten, John D Sears, Tina M Leisner, Paul B Hardy, Anirban Ghoshal, Michael A Stashko

bioRxiv· May 2024

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Discovery of Novel Macrocyclic MERTK/AXL Dual Inhibitors.
Deyu Kong, Qiang Tian, Zhilong Chen, Hongchao Zheng, Michael A Stashko

J Med Chem· April 2024

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SETDB1 Triple Tudor Domain Ligand, (,)-59, Promotes Methylation of Akt1 in Cells.
Mélanie Uguen, Yu Deng, Fengling Li, Devan J Shell, Jacqueline L Norris-Drouin, Michael A Stashko

ACS Chem Biol· August 2023

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SETDB1 Triple Tudor Domain Ligand, ( )-59, Promotes Methylation of Akt1 in Cells.
Mélanie Uguen, Yu Deng, Fengling Li, Devan J Shell, Jacqueline L Norris-Drouin, Michael A Stashko

bioRxiv· May 2023

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Development of Novel IP6K Inhibitors for the Treatment of Obesity and Obesity-Induced Metabolic Dysfunctions.
Yubai Zhou, Sandip Mukherjee, Daowei Huang, Molee Chakraborty, Chunfang Gu, Michael A Stashko

J Med Chem· May 2022

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The Synthesis and Initial Evaluation of MerTK Targeted PET Agents.
Li Wang, Yubai Zhou, Xuedan Wu, Xinrui Ma, Bing Li, Michael A Stashko

Molecules· February 2022

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Development of [F]MIPS15692, a radiotracer with in vitro proof-of-concept for the imaging of MER tyrosine kinase (MERTK) in neuroinflammatory disease.
Siu Wai Wong, Lucy Vivash, Ramesh Mudududdla, Nghi Nguyen, Stefan J Hermans, Michael A Stashko

Eur J Med Chem· December 2021

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UNC5293, a potent, orally available and highly MERTK-selective inhibitor.
Hongchao Zheng, Jichen Zhao, Bing Li, Weihe Zhang, Michael A Stashko

Eur J Med Chem· August 2021

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MerTK activity is not necessary for the proliferation of glioblastoma stem cells.
Monira Hoque, Siu Wai Wong, Ariadna Recasens, Ramzi Abbassi, Nghi Nguyen, Michael A Stashko

Biochem Pharmacol· April 2021

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Inhibition of Inositol Polyphosphate Kinases by Quercetin and Related Flavonoids: A Structure-Activity Analysis.
Chunfang Gu, Michael A Stashko, Ana C Puhl-Rubio, Molee Chakraborty, Anutosh Chakraborty

J Med Chem· February 2019

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Highly Selective MERTK Inhibitors Achieved by a Single Methyl Group.
Jichen Zhao, Dehui Zhang, Weihe Zhang, Michael A Stashko, Deborah DeRyckere

J Med Chem· November 2018

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Use of Protein Kinase-Focused Compound Libraries for the Discovery of New Inositol Phosphate Kinase Inhibitors.
Ana C Puhl-Rubio, Michael A Stashko, Huanchen Wang, P Brian Hardy, Vikas Tyagi

SLAS Discov· October 2018

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Retraction: A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors.
Brandi M Baughman, Huanchen Wang, Yi An, Dmitri Kireev, Michael A Stashko

PLoS One· June 2017

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A High-Throughput Screening-Compatible Strategy for the Identification of Inositol Pyrophosphate Kinase Inhibitors.
Brandi M Baughman, Huanchen Wang, Yi An, Dmitri Kireev, Michael A Stashko

PLoS One· May 2017

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Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors.
Andrew L McIver, Weihe Zhang, Qingyang Liu, Xinpeng Jiang, Michael A Stashko

ChemMedChem· February 2017

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Design and Synthesis of Novel Macrocyclic Mer Tyrosine Kinase Inhibitors.
Xiaodong Wang, Jing Liu, Weihe Zhang, Michael A Stashko, James Nichols

ACS Med Chem Lett· December 2016

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The MERTK/FLT3 inhibitor MRX-2843 overcomes resistance-conferring FLT3 mutations in acute myeloid leukemia.
Katherine A Minson, Catherine C Smith, Deborah DeRyckere, Clara Libbrecht, Alisa B Lee-Sherick, Michael A Stashko

JCI Insight· March 2016

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