Publications by authors named "Michael B Lazarus"

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Correction to "Characterization, Structure, and Inhibition of the Human Succinyl-CoA:glutarate-CoA Transferase, a Putative Genetic Modifier of Glutaric Aciduria Type 1".
Ruoxi Wu, Susmita Khamrui, Tetyana Dodatko, João Leandro, Amanda Sabovic, Michael B Lazarus

ACS Chem Biol· November 2025

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Structural insights into RNA cleavage by a novel family of bacterial RNases.
Ruoxi Wu, Shakti Ingle, Sarah A Barnes, Heather R Dahlin, Susmita Khamrui, Michael B Lazarus

Nucleic Acids Res· September 2024

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Characterization, Structure, and Inhibition of the Human Succinyl-CoA:glutarate-CoA Transferase, a Putative Genetic Modifier of Glutaric Aciduria Type 1.
Ruoxi Wu, Susmita Khamrui, Tetyana Dodatko, João Leandro, Amanda Sabovic, Michael B Lazarus

ACS Chem Biol· July 2024

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Characterization, structure and inhibition of the human succinyl-CoA:glutarate-CoA transferase, a genetic modifier of glutaric aciduria type 1.
Susmita Khamrui, Tetyana Dodatko, Ruoxi Wu, João Leandro, Amanda Sabovic, Michael B Lazarus

bioRxiv· February 2024

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A case of hyperlysinemia identified by urine newborn screening.
Mehdi Yeganeh, Christiane Auray-Blais, Bruno Maranda, Amanda Sabovic, Robert J DeVita, Michael B Lazarus

JIMD Rep· November 2023

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Selective Inhibitors of Autophagy Reveal New Link between the Cell Cycle and Autophagy and Lead to Discovery of Novel Synergistic Drug Combinations.
Kisa Sung, Agata Kurowski, Carisse Lansiquot, Kanny K Wan, Samarjit Patnaik, Michael B Lazarus

ACS Chem Biol· December 2022

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Characterization and structure of the human lysine-2-oxoglutarate reductase domain, a novel therapeutic target for treatment of glutaric aciduria type 1.
João Leandro, Susmita Khamrui, Chalada Suebsuwong, Peng-Jen Chen, Cody Secor, Michael B Lazarus

Open Biol· September 2022

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Discovery and initial characterization of YloC, a novel endoribonuclease in .
Shakti Ingle, Shivani Chhabra, Jiandong Chen, Michael B Lazarus, Xing Luo

RNA· February 2022

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Simple Secondary Amines Inhibit Growth of Gram-Negative Bacteria through Highly Selective Binding to Phenylalanyl-tRNA Synthetase.
Vadim Baidin, Tristan W Owens, Michael B Lazarus, Daniel Kahne

J Am Chem Soc· January 2021

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Inhibition and Crystal Structure of the Human DHTKD1-Thiamin Diphosphate Complex.
João Leandro, Susmita Khamrui, Hui Wang, Chalada Suebsuwong, Natalia S Nemeria, Michael B Lazarus

ACS Chem Biol· August 2020

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Structure-Activity Relationships and Biological Evaluation of 7-Substituted Harmine Analogs for Human β-Cell Proliferation.
Kunal Kumar, Peng Wang, Ethan A Swartz, Susmita Khamrui, Cody Secor, Michael B Lazarus

Molecules· April 2020

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High-Resolution Structure and Inhibition of the Schizophrenia-Linked Pseudokinase ULK4.
Susmita Khamrui, Peter M U Ung, Cody Secor, Avner Schlessinger, Michael B Lazarus

J Am Chem Soc· January 2020

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Structure-Based Evolution of Low Nanomolar O-GlcNAc Transferase Inhibitors.
Sara E S Martin, Zhi-Wei Tan, Harri M Itkonen, Damien Y Duveau, Joao A Paulo, Michael B Lazarus

J Am Chem Soc· October 2018

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The Antibiotic Novobiocin Binds and Activates the ATPase That Powers Lipopolysaccharide Transport.
Janine M May, Tristan W Owens, Michael D Mandler, Brent W Simpson, Michael B Lazarus

J Am Chem Soc· December 2017

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Discovery of new substrates of the elongation factor-2 kinase suggests a broader role in the cellular nutrient response.
Michael B Lazarus, Rebecca S Levin, Kevan M Shokat

Cell Signal· January 2017

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How the glycosyltransferase OGT catalyzes amide bond cleavage.
John Janetzko, Sunia A Trauger, Michael B Lazarus, Suzanne Walker

Nat Chem Biol· November 2016

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Discovery and structure of a new inhibitor scaffold of the autophagy initiating kinase ULK1.
Michael B Lazarus, Kevan M Shokat

Bioorg Med Chem· September 2015

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A small molecule that inhibits OGT activity in cells.
Rodrigo F Ortiz-Meoz, Jiaoyang Jiang, Michael B Lazarus, Marina Orman, John Janetzko

ACS Chem Biol· June 2015

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Structure of the human autophagy initiating kinase ULK1 in complex with potent inhibitors.
Michael B Lazarus, Chris J Novotny, Kevan M Shokat

ACS Chem Biol· January 2015

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Decoupling catalytic activity from biological function of the ATPase that powers lipopolysaccharide transport.
David J Sherman, Michael B Lazarus, Lea Murphy, Charles Liu, Suzanne Walker

Proc Natl Acad Sci U S A· April 2014

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HCF-1 is cleaved in the active site of O-GlcNAc transferase.
Michael B Lazarus, Jiaoyang Jiang, Vaibhav Kapuria, Tanja Bhuiyan, John Janetzko

Science· December 2013

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Structural snapshots of the reaction coordinate for O-GlcNAc transferase.
Michael B Lazarus, Jiaoyang Jiang, Tracey M Gloster, Wesley F Zandberg, Garrett E Whitworth

Nat Chem Biol· December 2012

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A neutral diphosphate mimic crosslinks the active site of human O-GlcNAc transferase.
Jiaoyang Jiang, Michael B Lazarus, Lincoln Pasquina, Piotr Sliz, Suzanne Walker

Nat Chem Biol· November 2011

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Structure of human O-GlcNAc transferase and its complex with a peptide substrate.
Michael B Lazarus, Yunsun Nam, Jiaoyang Jiang, Piotr Sliz, Suzanne Walker

Nature· January 2011

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Paclitaxel induces calcium oscillations via an inositol 1,4,5-trisphosphate receptor and neuronal calcium sensor 1-dependent mechanism.
Wolfgang Boehmerle, Ute Splittgerber, Michael B Lazarus, Kathleen M McKenzie, David G Johnston

Proc Natl Acad Sci U S A· November 2006

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