Publications by authors named "Michael B Sporn"

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The synthetic oleanane triterpenoid CDDO-2P-Im binds GRP78/BiP to induce unfolded protein response-mediated apoptosis in myeloma.
George Luo, Kristin Aldridge, Toby Chen, Vivek Aslot, Byung-Gyu Kim, Michael B Sporn

Mol Oncol· December 2023

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Nrf2 protects against radiation-induced oral mucositis via antioxidation and keratin layer thickening.
Shun Wakamori, Keiko Taguchi, Yuki Nakayama, Akira Ohkoshi, Michael B Sporn

Free Radic Biol Med· August 2022

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Distinct Regulations of Gene Expression for Stress Response and Substrate Induction.
Anqi Zhang, Takafumi Suzuki, Saki Adachi, Eriko Naganuma, Norio Suzuki, Michael B Sporn

Mol Cell Biol· October 2021

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CDDO-imidazolide Targets Multiple Amino Acid Residues on the Nrf2 Adaptor, Keap1.
Xiaoli Meng, James C Waddington, Arun Tailor, Adam Lister, Jane Hamlett, Michael B Sporn

J Med Chem· September 2020

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Retinoid X receptor agonist LG100268 modulates the immune microenvironment in preclinical breast cancer models.
Ana S Leal, Kayla Zydeck, Sarah Carapellucci, Lyndsey A Reich, Di Zhang, Michael B Sporn

NPJ Breast Cancer· November 2019

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Testing Novel Pyrimidinyl Rexinoids: A New Paradigm for Evaluating Rexinoids for Cancer Prevention.
Di Zhang, Ana S Leal, Sarah Carapellucci, Pritika H Shahani, Jaskaran S Bhogal, Michael B Sporn

Cancer Prev Res (Phila)· April 2019

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Chemoprevention of Preclinical Breast and Lung Cancer with the Bromodomain Inhibitor I-BET 762.
Di Zhang, Ana S Leal, Sarah Carapellucci, Kayla Zydeck, Michael B Sporn

Cancer Prev Res (Phila)· March 2018

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Design, synthesis, and biological activity of second-generation synthetic oleanane triterpenoids.
Liangfeng Fu, Qi-Xian Lin, Evans O Onyango, Karen T Liby, Michael B Sporn

Org Biomol Chem· July 2017

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Bromodomain inhibitors, JQ1 and I-BET 762, as potential therapies for pancreatic cancer.
Ana S Leal, Charlotte R Williams, Darlene B Royce, Patricia A Pioli, Michael B Sporn

Cancer Lett· May 2017

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The triterpenoid CDDO-imidazolide reduces immune cell infiltration and cytokine secretion in the KrasG12D;Pdx1-Cre (KC) mouse model of pancreatic cancer.
Ana S Leal, Michael B Sporn, Patricia A Pioli, Karen T Liby

Carcinogenesis· December 2016

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Rexinoids for prevention and treatment of cancer: opportunities and challenges.
Karen T Liby, Michael B Sporn

Curr Top Med Chem· June 2016

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Commentary on Eagle and Foley: "Cytotoxicity in Human Cell Cultures".
Michael B Sporn

Cancer Res· March 2016

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The Rexinoids LG100268 and LG101506 Inhibit Inflammation and Suppress Lung Carcinogenesis in A/J Mice.
Martine Cao, Darlene B Royce, Renee Risingsong, Charlotte R Williams, Michael B Sporn

Cancer Prev Res (Phila)· January 2016

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A synthetic triterpenoid CDDO-Im inhibits tumorsphere formation by regulating stem cell signaling pathways in triple-negative breast cancer.
Jae Young So, Janice J Lin, Joseph Wahler, Karen T Liby, Michael B Sporn

PLoS One· December 2015

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Novel synthetic pyridyl analogues of CDDO-Imidazolide are useful new tools in cancer prevention.
Martine Cao, Evans O Onyango, Charlotte R Williams, Darlene B Royce, Gordon W Gribble, Michael B Sporn

Pharmacol Res· October 2015

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Dimethyl fumarate and the oleanane triterpenoids, CDDO-imidazolide and CDDO-methyl ester, both activate the Nrf2 pathway but have opposite effects in the A/J model of lung carcinogenesis.
Ciric To, Carol S Ringelberg, Darlene B Royce, Charlotte R Williams, Renee Risingsong, Michael B Sporn

Carcinogenesis· July 2015

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Neuroprotective role of Nrf2 for retinal ganglion cells in ischemia-reperfusion.
Zhenhua Xu, Hongkwan Cho, Matthew J Hartsock, Katherine L Mitchell, Junsong Gong, Michael B Sporn

J Neurochem· April 2015

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PARP inhibitors for chemoprevention--reply.
Ciric To, Michael B Sporn, Karen T Liby

Cancer Prev Res (Phila)· November 2014

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Complete protection against aflatoxin B(1)-induced liver cancer with a triterpenoid: DNA adduct dosimetry, molecular signature, and genotoxicity threshold.
Natalie M Johnson, Patricia A Egner, Victoria K Baxter, Michael B Sporn, Ryan S Wible

Cancer Prev Res (Phila)· July 2014

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The PARP inhibitors, veliparib and olaparib, are effective chemopreventive agents for delaying mammary tumor development in BRCA1-deficient mice.
Ciric To, Eun-Hee Kim, Darlene B Royce, Charlotte R Williams, Ryan M Collins, Michael B Sporn

Cancer Prev Res (Phila)· July 2014

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An efficient synthesis of methyl 2-cyano-3,12-dioxoursol-1,9-dien-28-oate (CDDU-methyl ester): analogues, biological activities, and comparison with oleanolic acid derivatives.
Liangfeng Fu, Qi-Xian Lin, Karen T Liby, Michael B Sporn, Gordon W Gribble

Org Biomol Chem· July 2014

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Synthetic triterpenoid induces 15-PGDH expression and suppresses inflammation-driven colon carcinogenesis.
Sung Hee Choi, Byung-Gyu Kim, Janet Robinson, Steve Fink, Min Yan, Michael B Sporn

J Clin Invest· June 2014

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Pillars Article: production of transforming growth factor β by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med. 1986. 163: 1037-1050.
John H Kehrl, Lalage M Wakefield, Anita B Roberts, Sonia Jakowlew, Melchor Alvarez-Mon, Michael B Sporn

J Immunol· April 2014

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The Nrf2 triterpenoid activator, CDDO-imidazolide, protects kidneys from ischemia-reperfusion injury in mice.
Manchang Liu, Narsa M Reddy, Elizabeth M Higbee, Haranatha R Potteti, Sanjeev Noel, Michael B Sporn

Kidney Int· January 2014

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Synthesis and biological evaluation of amino acid methyl ester conjugates of 2-cyano-3,12-dioxooleana-1,9(11)-dien-28-oic acid against the production of nitric oxide (NO).
Evans O Onyango, Liangfeng Fu, Martine Cao, Karen T Liby, Michael B Sporn

Bioorg Med Chem Lett· January 2014

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