Publications by authors named "Michael D Gaul"

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Discovery of Potent and Orally Bioavailable Pyridine N-Oxide-Based Factor XIa Inhibitors through Exploiting Nonclassical Interactions.
Guozhang Xu, Zhijie Liu, Xinkang Wang, Tianbao Lu, Renee L DesJarlais, Michael D Gaul

J Med Chem· August 2022

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Hit-to-lead optimization and discovery of a potent, and orally bioavailable G protein coupled receptor kinase 2 (GRK2) inhibitor.
Guozhang Xu, Michael D Gaul, Zhijie Liu, Renee L DesJarlais, Jenson Qi

Bioorg Med Chem Lett· December 2020

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5,5-Difluoro- and 5-Fluoro-5-methyl-hexose-based C-Glucosides as potent and orally bioavailable SGLT1 and SGLT2 dual inhibitors.
Guozhang Xu, Fuyong Du, Gee-Hong Kuo, June Zhi Xu, Yin Liang, Michael D Gaul

Bioorg Med Chem Lett· September 2020

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Discovery of potent and orally bioavailable indazole-based glucagon receptor antagonists for the treatment of type 2 diabetes.
Guozhang Xu, Michael D Gaul, Fengbin Song, Fuyong Du, Yin Liang

Bioorg Med Chem Lett· October 2019

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Design, synthesis and structure activity relationships of indazole and indole derivatives as potent glucagon receptor antagonists.
Fengbin Song, Guozhang Xu, Michael D Gaul, Baoping Zhao, Tianbao Lu

Bioorg Med Chem Lett· August 2019

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Design, synthesis and biological evaluation of (2S,3R,4R,5S,6R)-5-fluoro-6-(hydroxymethyl)-2-aryltetrahydro-2H-pyran-3,4-diols as potent and orally active SGLT dual inhibitors.
Guozhang Xu, Michael D Gaul, Gee-Hong Kuo, Fuyong Du, June Zhi Xu

Bioorg Med Chem Lett· November 2018

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Metabolic tracing of monoacylglycerol acyltransferase-2 activity in vitro and in vivo.
Jenson Qi, Wensheng Lang, Margery A Connelly, Fuyong Du, Yin Liang, Michael D Gaul

Anal Biochem· May 2017

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Synthesis of β-Substituted Cyclic Enones via Phosphonium Salt-Activated, Palladium-Catalyzed Cross-Coupling of Cyclic 1,3-Diones.
Shyh-Ming Yang, Gee-Hong Kuo, Michael D Gaul, William V Murray

J Org Chem· April 2016

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4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable stearoyl-CoA desaturase-1 (SCD1) inhibitors: part 2. Pyridazine-based analogs.
Shyh-Ming Yang, Yuting Tang, Thomas Rano, Huajun Lu, Gee-Hong Kuo, Michael D Gaul

Bioorg Med Chem Lett· March 2014

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4-Bicyclic heteroaryl-piperidine derivatives as potent, orally bioavailable Stearoyl-CoA desaturase-1 (SCD1) inhibitors. Part 1: urea-based analogs.
Shyh-Ming Yang, Yuting Tang, Rui Zhang, Huajun Lu, Gee-Hong Kuo, Michael D Gaul

Bioorg Med Chem Lett· December 2013

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Design and synthesis of polyethylene glycol-modified biphenylsulfonyl-thiophene-carboxamidine inhibitors of the complement component C1s.
Nalin L Subasinghe, Ehab Khalil, Jeremy M Travins, Farah Ali, Shelley K Ballentine, Michael D Gaul

Bioorg Med Chem Lett· August 2012

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Thienopyrimidine-based dual EGFR/ErbB-2 inhibitors.
Tara R Rheault, Thomas R Caferro, Scott H Dickerson, Kelly H Donaldson, Michael D Gaul

Bioorg Med Chem Lett· February 2009

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Synthesis and biological study of 4-aminopyrimidine-5-carboxaldehyde oximes as antiproliferative VEGFR-2 inhibitors.
Shenlin Huang, Ronghua Li, Peter J Connolly, Guozhang Xu, Michael D Gaul

Bioorg Med Chem Lett· December 2006

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Substrate specificity and novel selective inhibitors of TNF-alpha converting enzyme (TACE) from two-dimensional substrate mapping.
Millard H Lambert, R Kevin Blackburn, Theresa D Seaton, Daniel B Kassel, Daniel S Kinder, Michael D Gaul

Comb Chem High Throughput Screen· June 2005

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CYP3A induction by N-hydroxyformamide tumor necrosis factor-alpha converting enzyme/matrix metalloproteinase inhibitors use of a pregname X receptor activation assay and primary hepatocyte culture for assessing induction potential in humans.
Timothy K Tippin, Geraldine Hamilton, Linda Moore, Elizabeth J Beaudet, Summer Jolley, Michael D Gaul

Drug Metab Dispos· July 2003

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