Publications by authors named "Michael D Lewis"

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Biparental Inheritance and Instability of kDNA in Experimental Hybrids of : A Proposal for a Mechanism.
Nicolás Tomasini, Tatiana Ponce, Fanny Rusman, Soledad Hodi, Noelia Floridia-Yapur, Michael D Lewis

Biology (Basel)· October 2025

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Intermittent suppressive posaconazole therapy is ineffective at mitigating cardiac and digestive tract pathologies in an experimental model of chronic Chagas disease.
Shiromani Jayawardhana, Francisco Olmo, Amanda Fortes Francisco, Archie A Khan, Michael D Lewis

Antimicrob Agents Chemother· June 2025

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Pharmacokinetic-pharmacodynamic modeling of benznidazole and its antitrypanosomal activity in a murine model of chronic Chagas disease.
Frauke Assmus, Ayorinde Adehin, Richard M Hoglund, Amanda Fortes Francisco, Michael D Lewis

PLoS Negl Trop Dis· May 2025

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Animal models for exploring Chagas disease pathogenesis and supporting drug discovery.
Archie A Khan, Martin C Taylor, Amanda Fortes Francisco, Shiromani Jayawardhana, Richard L Atherton, Michael D Lewis

Clin Microbiol Rev· December 2024

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Dynamics of Trypanosoma cruzi infection in hamsters and novel association with progressive motor dysfunction.
Harry Langston, Amanda Fortes Francisco, Ciaran Doidge, Chrissy H Roberts, Archie A Khan, Michael D Lewis

PLoS Negl Trop Dis· June 2024

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Enteric nervous system regeneration and functional cure of experimental digestive Chagas disease with trypanocidal chemotherapy.
Archie A Khan, Harry C Langston, Louis Walsh, Rebecca Roscoe, Shiromani Jayawardhana, Michael D Lewis

Nat Commun· May 2024

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A panel of phenotypically and genotypically diverse bioluminescent:fluorescent Trypanosoma cruzi strains as a resource for Chagas disease research.
Francisco Olmo, Shiromani Jayawardhana, Archie A Khan, Harry C Langston, Amanda Fortes Francisco, Michael D Lewis

PLoS Negl Trop Dis· May 2024

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Benznidazole treatment leads to DNA damage in Trypanosoma cruzi and the persistence of rare widely dispersed non-replicative amastigotes in mice.
Shiromani Jayawardhana, Alexander I Ward, Amanda F Francisco, Michael D Lewis, Martin C Taylor

PLoS Pathog· November 2023

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Cardiac Abnormalities in a Predictive Mouse Model of Chagas Disease.
Amanda Fortes Francisco, Giovane R Sousa, Mhairi Vaughan, Harry Langston, Archie Khan, Michael D Lewis

Pathogens· November 2023

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Impact of Visceral Leishmaniasis on Local Organ Metabolism in Hamsters.
Mahbobeh Lesani, Camil Gosmanov, Andrea Paun, Michael D Lewis, Laura-Isobel McCall

Metabolites· August 2022

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Microevolution of reveals hybridization and clonal mechanisms driving rapid genome diversification.
Gabriel Machado Matos, Michael D Lewis, Carlos Talavera-López, Matthew Yeo, Edmundo C Grisard

Elife· May 2022

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Incomplete Recruitment of Protective T Cells Is Associated with Trypanosoma cruzi Persistence in the Mouse Colon.
Alexander I Ward, Michael D Lewis, Martin C Taylor, John M Kelly

Infect Immun· February 2022

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Local association of Trypanosoma cruzi chronic infection foci and enteric neuropathic lesions at the tissue micro-domain scale.
Archie A Khan, Harry C Langston, Fernanda C Costa, Francisco Olmo, Martin C Taylor, Michael D Lewis

PLoS Pathog· August 2021

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Bioluminescent:Fluorescent Trypanosoma cruzi Reporter Strains as Tools for Exploring Chagas Disease Pathogenesis and Drug Activity.
Martin C Taylor, Alexander I Ward, Francisco Olmo, Amanda F Francisco, Shiromani Jayawardhana, Michael D Lewis

Curr Pharm Des· June 2021

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Repeat-Driven Generation of Antigenic Diversity in a Major Human Pathogen, .
Carlos Talavera-López, Louisa A Messenger, Michael D Lewis, Matthew Yeo, João Luís Reis-Cunha

Front Cell Infect Microbiol· June 2021

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Host-parasite dynamics in Chagas disease from systemic to hyper-local scales.
Damián Pérez-Mazliah, Alexander I Ward, Michael D Lewis

Parasite Immunol· February 2021

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Opportunities, Pitfalls, and Alternatives in Adapting Electronic Health Records for Health Services Research.
Glen B Taksler, Jarrod E Dalton, Adam T Perzynski, Michael B Rothberg, Alex Milinovich, Michael D Lewis

Med Decis Making· February 2021

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Culture-free genome-wide locus sequence typing (GLST) provides new perspectives on Trypanosoma cruzi dispersal and infection complexity.
Philipp Schwabl, Jalil Maiguashca Sánchez, Jaime A Costales, Sofía Ocaña-Mayorga, Maikell Segovia, Michael D Lewis

PLoS Genet· December 2020

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Analysis of Trypanosoma cruzi Persistence Foci at Single-Cell Resolution.
Alexander I Ward, Michael D Lewis, Archie A Khan, Conor J McCann, Amanda F Francisco

mBio· August 2020

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Challenges in Chagas Disease Drug Development.
Amanda F Francisco, Shiromani Jayawardhana, Francisco Olmo, Michael D Lewis, Shane R Wilkinson

Molecules· June 2020

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Fatal progression of experimental visceral leishmaniasis is associated with intestinal parasitism and secondary infection by commensal bacteria, and is delayed by antibiotic prophylaxis.
Michael D Lewis, Andrea Paun, Audrey Romano, Harry Langston, Charlotte A Langner

PLoS Pathog· April 2020

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Drug-cured experimental Trypanosoma cruzi infections confer long-lasting and cross-strain protection.
Gurdip Singh Mann, Amanda F Francisco, Shiromani Jayawardhana, Martin C Taylor, Michael D Lewis

PLoS Negl Trop Dis· April 2020

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Intracellular DNA replication and differentiation of Trypanosoma cruzi is asynchronous within individual host cells in vivo at all stages of infection.
Martin C Taylor, Alexander Ward, Francisco Olmo, Shiromani Jayawardhana, Amanda F Francisco, Michael D Lewis

PLoS Negl Trop Dis· March 2020

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Exploiting Genetically Modified Dual-Reporter Strains to Monitor Experimental Trypanosoma cruzi Infections and Host-Parasite Interactions.
Martin C Taylor, Amanda F Francisco, Shiromani Jayawardhana, Gurdip Singh Mann, Alexander I Ward, Michael D Lewis

Methods Mol Biol· July 2019

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Assessing the Effectiveness of Curative Benznidazole Treatment in Preventing Chronic Cardiac Pathology in Experimental Models of Chagas Disease.
Amanda Fortes Francisco, Shiromani Jayawardhana, Martin C Taylor, Michael D Lewis, John M Kelly

Antimicrob Agents Chemother· October 2018

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