Publications by authors named "Michael Desch"

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The Effect of Multiple Oral Doses of a Glycine Transporter 1 Inhibitor, Iclepertin (BI 425809), on the Steady-state Pharmacokinetics of a Combined Oral Contraceptive Containing Ethinylestradiol and Levonorgestrel: a Phase I Clinical Trial in Healthy Females.
Shilpa Madari, Yesilda Balavarca, Yury Shatillo, Corey Reuteman-Fowler, Michael Desch

Clin Drug Investig· October 2025

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Assessing the Effect of Food on the Pharmacokinetics of Iclepertin in Healthy Volunteers: A Phase I, Open-Label, Randomised, Cross-over Trial.
Shilpa Madari, Kerstin Breithaupt-Groegler, Brett A English, Kathrin Hohl, Arvid Jungnik, Michael Desch

Eur J Drug Metab Pharmacokinet· September 2025

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Pre-Emptive Drug Safety Evaluation of Iclepertin (BI-425809) Using Real-World Data and Virtual Addition of This Medication to the Actual Drug Regimen of Individuals from Large Populations.
Sebastian Härtter, Veronique Michaud, Matt K Smith, Pamela Dow, Gerald Condon, Michael Desch

Pharmaceuticals (Basel)· September 2025

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Evaluation of the Drug-Drug Interaction Potential of the GlyT1 Inhibitor Iclepertin (BI 425809): A Physiologically Based Pharmacokinetic (PBPK) Modeling Approach.
Elin M Matsson, Michael Desch, Valerie Nock, Nina Hanke

CPT Pharmacometrics Syst Pharmacol· August 2025

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Development of the novel GlyT1 inhibitor, iclepertin (BI 425809), for the treatment of cognitive impairment associated with schizophrenia.
Holger Rosenbrock, Michael Desch, Glen Wunderlich

Eur Arch Psychiatry Clin Neurosci· October 2023

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Phase I studies of the safety, tolerability, pharmacokinetics and pharmacodynamics of the dual glucagon receptor/glucagon-like peptide-1 receptor agonist BI 456906.
Arvid Jungnik, Jorge Arrubla Martinez, Leona Plum-Mörschel, Christoph Kapitza, Daniela Lamers, Michael Desch

Diabetes Obes Metab· April 2023

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Pharmacokinetic-Interactions of BI 425809, a Novel Glycine Transporter 1 Inhibitor, With Cytochrome P450 and P-Glycoprotein Substrates: Findings From In Vitro Analyses and an Open-Label, Single-Sequence Phase I Study.
Michael Desch, Christina Schlecker, Kathrin Hohl, Karl-Heinz Liesenfeld, Tom Chan

J Clin Psychopharmacol· March 2023

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Correction to: The Absolute Bioavailability, Absorption, Distribution, Metabolism, and Excretion of BI 425809 Administered as an Oral Dose or an Oral Dose with an Intravenous Microtracer Dose of [C]‑BI 425809 in Healthy Males.
Ute Burkard, Michael Desch, Yury Shatillo, Glen Wunderlich, Salome Rebecca Mack

Clin Drug Investig· April 2022

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Effects of Cytochrome P450 3A4 Induction and Inhibition on the Pharmacokinetics of BI 425809, a Novel Glycine Transporter 1 Inhibitor.
Michael Desch, Glen Wunderlich, Markus Goettel, Sophia Goetz, Karl-Heinz Liesenfeld

Eur J Drug Metab Pharmacokinet· January 2022

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The Absolute Bioavailability, Absorption, Distribution, Metabolism, and Excretion of BI 425809 Administered as an Oral Dose or an Oral Dose with an Intravenous Microtracer Dose of [C]-BI 425809 in Healthy Males.
Ute Burkard, Michael Desch, Yury Shatillo, Glen Wunderlich, Salome Rebecca Mack

Clin Drug Investig· January 2022

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Efficacy and safety of the novel glycine transporter inhibitor BI 425809 once daily in patients with schizophrenia: a double-blind, randomised, placebo-controlled phase 2 study.
W Wolfgang Fleischhacker, Jana Podhorna, Martina Gröschl, Sanjay Hake, Yihua Zhao, Michael Desch

Lancet Psychiatry· March 2021

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Evaluation of Pharmacokinetics and Pharmacodynamics of BI 425809, a Novel GlyT1 Inhibitor: Translational Studies.
Holger Rosenbrock, Michael Desch, Oliver Kleiner, Cornelia Dorner-Ciossek, Bernhard Schmid

Clin Transl Sci· November 2018

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Multiple Rising Doses of Oral BI 425809, a GlyT1 Inhibitor, in Young and Elderly Healthy Volunteers: A Randomised, Double-Blind, Phase I Study Investigating Safety and Pharmacokinetics.
Viktoria Moschetti, Christina Schlecker, Sven Wind, Sophia Goetz, Holger Schmitt, Michael Desch

Clin Drug Investig· August 2018

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Safety, Tolerability and Pharmacokinetics of Oral BI 425809, a Glycine Transporter 1 Inhibitor, in Healthy Male Volunteers: A Partially Randomised, Single-Blind, Placebo-Controlled, First-in-Human Study.
Viktoria Moschetti, Michael Desch, Sophia Goetz, Karl-Heinz Liesenfeld, Holger Rosenbrock

Eur J Drug Metab Pharmacokinet· April 2018

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Chicken ovalbumin upstream promoter transcription factor II regulates renin gene expression.
Sandra Mayer, Marc Roeser, Peter Lachmann, Sumiyashi Ishii, Jae Mi Suh, Michael Desch

J Biol Chem· July 2012

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Identification of ATF2 as a transcriptional regulator of renin gene.
Michael Desch, Gerit Hackmayer, Vladimir T Todorov

Biol Chem· January 2012

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cAMP target sequences enhCRE and CNRE sense low-salt intake to increase human renin gene expression in vivo.
Michael Desch, Sabine Harlander, Björn Neubauer, Melanie Gerl, Stephane Germain

Pflugers Arch· May 2011

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PPARgamma-dependent regulation of adenylate cyclase 6 amplifies the stimulatory effect of cAMP on renin gene expression.
Michael Desch, Thomas Schubert, Andrea Schreiber, Sandra Mayer, Björn Friedrich

Mol Endocrinol· November 2010

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Regulation of the renin expression in the retinal pigment epithelium by systemic stimuli.
Vladimir M Milenkovic, Marisa Brockmann, Christian Meyer, Michael Desch, Frank Schweda

Am J Physiol Renal Physiol· August 2010

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Increased renin production in mice with deletion of peroxisome proliferator-activated receptor-gamma in juxtaglomerular cells.
Michael Desch, Andrea Schreiber, Frank Schweda, Kirsten Madsen, Ulla G Friis

Hypertension· March 2010

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The Pal3 promoter sequence is critical for the regulation of human renin gene transcription by peroxisome proliferator-activated receptor-gamma.
Vladimir T Todorov, Michael Desch, Thomas Schubert, Armin Kurtz

Endocrinology· September 2008

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Peroxisome proliferator-activated receptor-gamma is involved in the control of renin gene expression.
Vladimir T Todorov, Michael Desch, Nina Schmitt-Nilson, Anelia Todorova, Armin Kurtz

Hypertension· November 2007

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Pituitary adenylate cyclase-activating polypeptide stimulates renin secretion via activation of PAC1 receptors.
Matthias Hautmann, Ulla G Friis, Michael Desch, Vladimir Todorov, Hayo Castrop

J Am Soc Nephrol· April 2007

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