Publications by authors named "Michael Geeves"

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Conserved Phosphorylation of the Myosin1e TH1 Domain Impacts Membrane Association and Function in Yeast and Worms.
Holly R Brooker, Karen Baker, Marina Ezcurra, Philippe P Laissue, Lin Wang, Michael A Geeves

Cytoskeleton (Hoboken)· December 2025

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Extracellular vesicle-linked vitamin B12 acquisition via novel binding proteins in Bacteroides thetaiotaomicron.
Rokas Juodeikis, Robert Ulrich, Charlea Clarke, Michal Banasik, Evelyne Deery, Michael A Geeves

Biochem J· December 2025

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Direct measurement of mavacamten and deoxyATP perturbation of the SRX/DRX ratio in porcine cardiac myofibrils using a simple, accessible and multiplexed approach.
Matvey Pilagov, Ateeqa Naim, Kenneth S Campbell, Thomas Kampourakis, Michael A Geeves

J Muscle Res Cell Motil· December 2025

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Molecular mechanisms of altered contraction with the β-myosin R403Q mutation in porcine ventricular muscle and a human stem cell-derived cardiomyocyte model.
Sonette Steczina, Saffie Mohran, Matthew C Childers, Timothy S McMillen, Ateeqa Naim, Michael A Geeves

J Mol Cell Cardiol· December 2025

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Spatially resolving how cMyBP-C phosphorylation and haploinsufficiency in porcine and human myofibrils affect β-cardiac myosin activity.
Matvey Pilagov, Sonette Steczina, Ateeqa Naim, Michael Regnier, Michael A Geeves

J Gen Physiol· September 2025

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Molecular mechanisms of altered contraction with the β-myosin R403Q mutation in porcine ventricular muscle and a human stem cell-derived cardiomyocyte model.
Sonette Steczina, Saffie Mohran, Matthew C Childers, Timothy S McMillen, Ateeqa Naim, Michael A Geeves

bioRxiv· September 2025

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Rapid changes in hydrostatic pressure as a probe for correlating function of purified proteins with their measured activity in living cells.
Daniel P Mulvihill, Michael A Geeves

Biophys Rev· August 2025

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Interacting myosin head dynamics and their modification by 2'-deoxy-ADP.
Matthew Carter Childers, Michael A Geeves, Michael Regnier

Biophys J· November 2024

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Motor domain phosphorylation increases nucleotide exchange and turns MYO6 into a faster and stronger motor.
Janeska J de Jonge, Andreas Graw, Vasileios Kargas, Christopher Batters, Antonino F Montanarella, Michael A Geeves

Nat Commun· August 2024

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MYBPC3-c.772G>A mutation results in haploinsufficiency and altered myosin cycling kinetics in a patient induced stem cell derived cardiomyocyte model of hypertrophic cardiomyopathy.
Sonette Steczina, Saffie Mohran, Logan R J Bailey, Timothy S McMillen, Kristina B Kooiker, Michael A Geeves

J Mol Cell Cardiol· June 2024

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An atomistic model of myosin interacting heads motif dynamics and their modification by 2'-deoxy-ADP.
Matthew Carter Childers, Michael A Geeves, Michael Regnier

bioRxiv· June 2024

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Myosin's powerstroke transitions define atomic scale movement of cardiac thin filament tropomyosin.
Michael J Rynkiewicz, Matthew C Childers, Olga E Karpicheva, Michael Regnier, Michael A Geeves

J Gen Physiol· May 2024

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The biochemically defined super relaxed state of myosin-A paradox.
Saffie Mohran, Kristina Kooiker, Max Mahoney-Schaefer, Christian Mandrycky, Kerry Kao, Michael Geeves

J Biol Chem· January 2024

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Protocols for Myosin and Actin-Myosin Assays Using Rapid, Stopped-Flow Kinetics.
Kerry Kao, Michael A Geeves

Methods Mol Biol· December 2023

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Danicamtiv Increases Myosin Recruitment and Alters Cross-Bridge Cycling in Cardiac Muscle.
Kristina B Kooiker, Saffie Mohran, Kyrah L Turner, Weikang Ma, Amy Martinson, Michael A Geeves

Circ Res· August 2023

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Comparing the effects of chemical Ca dyes and R-GECO on contractility and Ca transients in adult and human iPSC cardiomyocytes.
Paul Robinson, Alexander J Sparrow, Yiangos Psaras, Violetta Steeples, Jillian N Simon, Michael A Geeves

J Mol Cell Cardiol· July 2023

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Distinct effects of two hearing loss-associated mutations in the sarcomeric myosin MYH7b.
Lindsey A Lee, Samantha K Barrick, Ada E Buvoli, Jonathan Walklate, W Tom Stump, Michael Geeves

J Biol Chem· May 2023

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Danicamtiv increases myosin recruitment and alters the chemomechanical cross bridge cycle in cardiac muscle.
Kristina B Kooiker, Saffie Mohran, Kyrah L Turner, Weikang Ma, Galina Flint, Michael A Geeves

bioRxiv· February 2023

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Functional divergence of the sarcomeric myosin, MYH7b, supports species-specific biological roles.
Lindsey A Lee, Samantha K Barrick, Artur Meller, Jonathan Walklate, Jeffrey M Lotthammer, Michael A Geeves

J Biol Chem· January 2023

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Single-molecule imaging reveals how mavacamten and PKA modulate ATP turnover in skeletal muscle myofibrils.
Matvey Pilagov, Laurens W H J Heling, Jonathan Walklate, Michael A Geeves, Neil M Kad

J Gen Physiol· January 2023

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Pseudo-phosphorylation of essential light chains affects the functioning of skeletal muscle myosin.
Daria S Yampolskaya, Galina V Kopylova, Daniil V Shchepkin, Salavat R Nabiev, Larisa V Nikitina, Michael A Geeves

Biophys Chem· January 2023

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Exploring the super-relaxed state of myosin in myofibrils from fast-twitch, slow-twitch, and cardiac muscle.
Jonathan Walklate, Kerry Kao, Michael Regnier, Michael A Geeves

J Biol Chem· March 2022

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Acetylation stabilises calmodulin-regulated calcium signalling.
Karen Baker, Michael A Geeves, Daniel P Mulvihill

FEBS Lett· March 2022

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Effect of Myosin Isoforms on Cardiac Muscle Twitch of Mice, Rats and Humans.
Momcilo Prodanovic, Michael A Geeves, Corrado Poggesi, Michael Regnier, Srboljub M Mijailovich

Int J Mol Sci· January 2022

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Alpha and beta myosin isoforms and human atrial and ventricular contraction.
Jonathan Walklate, Cecilia Ferrantini, Chloe A Johnson, Chiara Tesi, Corrado Poggesi, Michael A Geeves

Cell Mol Life Sci· December 2021

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