Publications by authors named "Michael Gotthardt"

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Prime editing corrects the dilated cardiomyopathy causing RBM20-P633L-mutation in human cardiomyocytes.
Alexandra Roman, Anja Zimmer, Michael Gotthardt, Lars M Steinmetz, Ralf Kühn

Mol Ther Nucleic Acids· December 2025

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Rbm20 antisense oligonucleotides alleviate diastolic dysfunction in a mouse model of cardiometabolic heart failure (HFpEF).
Mei Methawasin, Stefan Meinke, Michael H Radke, Gerrie P Farman, Zaynab Hourani, Michael Gotthardt

Cardiovasc Res· October 2025

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RNA-binding proteins as therapeutic targets in cardiac fibrosis and heart failure.
Michael Gotthardt

Eur Heart J· September 2025

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Deep phenotyping of heart failure with preserved ejection fraction through multi-omics integration.
Jakob Versnjak, Titus Kuehne, Pauline Fahjen, Nina Jovanovic, Ulrike Löber, Michael Gotthardt

Eur J Heart Fail· September 2025

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Stochastic model of IP3-induced Ca2+ spiking of HEK293 cells.
Caterina Azzoni, Rene Jüttner, Anje Sporbert, Michael Gotthardt, H Llewelyn Roderick

PLoS Comput Biol· August 2025

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Visualizing sarcomere and cellular dynamics in skeletal muscle to improve cell therapies.
Judith Hüttemeister, Franziska Rudolph, Michael H Radke, Claudia Fink, Dhana Friedrich, Michael Gotthardt

Elife· December 2024

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Titin's cardiac-specific N2B element is critical to mechanotransduction during volume overload of the heart.
Joshua Strom, Mathew Bull, Jochen Gohlke, Chandra Saripalli, Mei Methawasin, Michael Gotthardt

J Mol Cell Cardiol· June 2024

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Correction to: Cardiac sarcomere mechanics in health and disease.
Claudia Crocini, Michael Gotthardt

Biophys Rev· April 2024

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SERCA2a microdomain cAMP changes in heart failure with preserved ejection fraction.
Michael Gotthardt, Stephan E Lehnart

Cardiovasc Res· March 2024

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Loss of Cardiac Splicing Regulator Is Associated With Early-Onset Atrial Fibrillation.
Oliver B Vad, Elisavet Angeli, Martin Liss, Gustav Ahlberg, Laura Andreasen, Michael Gotthardt

JACC Basic Transl Sci· February 2024

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Cardiac splicing as a diagnostic and therapeutic target.
Michael Gotthardt, Victor Badillo-Lisakowski, Victoria Nicole Parikh, Euan Ashley, Marta Furtado

Nat Rev Cardiol· August 2023

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Mislocalization of pathogenic RBM20 variants in dilated cardiomyopathy is caused by loss-of-interaction with Transportin-3.
Julia Kornienko, Marta Rodríguez-Martínez, Kai Fenzl, Florian Hinze, Daniel Schraivogel, Michael Gotthardt

Nat Commun· July 2023

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Striated muscle-specific base editing enables correction of mutations causing dilated cardiomyopathy.
Markus Grosch, Laura Schraft, Adrian Chan, Leonie Küchenhoff, Kleopatra Rapti, Michael Gotthardt

Nat Commun· June 2023

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Disease- and sex-specific differences in patients with heart valve disease: a proteome study.
Sarah Nordmeyer, Milena Kraus, Matthias Ziehm, Marieluise Kirchner, Marie Schafstedde, Michael Gotthardt

Life Sci Alliance· March 2023

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Evolutionary origins and interactomes of human, young microproteins and small peptides translated from short open reading frames.
Clara-L Sandmann, Jana F Schulz, Jorge Ruiz-Orera, Marieluise Kirchner, Matthias Ziehm, Michael Gotthardt

Mol Cell· March 2023

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CAR links hypoxia signaling to improved survival after myocardial infarction.
Fabian Freiberg, Meghna Thakkar, Wiebke Hamann, Jacobo Lopez Carballo, Rene Jüttner, Michael Gotthardt

Exp Mol Med· March 2023

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A single-cell RNA labeling strategy for measuring stress response upon tissue dissociation.
Anika Neuschulz, Olga Bakina, Victor Badillo-Lisakowski, Pedro Olivares-Chauvet, Thomas Conrad, Michael Gotthardt

Mol Syst Biol· February 2023

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The IgCAM CAR Regulates Gap Junction-Mediated Coupling on Embryonic Cardiomyocytes and Affects Their Beating Frequency.
Claudia Matthaeus, René Jüttner, Michael Gotthardt, Fritz G Rathjen

Life (Basel)· December 2022

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Epithelial coxsackievirus adenovirus receptor promotes house dust mite-induced lung inflammation.
Elena Ortiz-Zapater, Dustin C Bagley, Virginia Llopis Hernandez, Luke B Roberts, Thomas J A Maguire, Michael Gotthardt

Nat Commun· October 2022

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Proteome-wide quantitative RNA-interactome capture identifies phosphorylation sites with regulatory potential in RBM20.
Carlos Henrique Vieira-Vieira, Vita Dauksaite, Anje Sporbert, Michael Gotthardt, Matthias Selbach

Mol Cell· June 2022

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RBM20 phosphorylation and its role in nucleocytoplasmic transport and cardiac pathogenesis.
Yanghai Zhang, Chunyan Wang, Mingming Sun, Yutong Jin, Camila Urbano Braz, Michael Gotthardt

FASEB J· May 2022

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HDAC6 modulates myofibril stiffness and diastolic function of the heart.
Ying-Hsi Lin, Jennifer L Major, Tim Liebner, Zaynab Hourani, Joshua G Travers, Michael Gotthardt

J Clin Invest· May 2022

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Therapeutic inhibition of RBM20 improves diastolic function in a murine heart failure model and human engineered heart tissue.
Michael H Radke, Victor Badillo-Lisakowski, Thiago Britto-Borges, Dieter A Kubli, René Jüttner, Michael Gotthardt

Sci Transl Med· December 2021

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Cardiac sarcomere mechanics in health and disease.
Claudia Crocini, Michael Gotthardt

Biophys Rev· October 2021

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RBM20-Related Cardiomyopathy: Current Understanding and Future Options.
Jan Koelemen, Michael Gotthardt, Lars M Steinmetz, Benjamin Meder

J Clin Med· September 2021

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