Publications by authors named "Michael Handlogten"

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Accelerated cell culture process development and characterization for cilgavimab/tixagevimab (AZD7442) for the prevention and treatment of COVID-19.
Michael W Handlogten, Stefanie Bosley, Sarah Dunn, Jie Zhu, Allison Lee-O'Brien

Biotechnol Bioeng· September 2025

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Elevated endoplasmic reticulum pH is associated with high growth and bisAb aggregation in CHO cells.
Kevin S McFarland, Kaitlin Hegadorn, Michael J Betenbaugh, Michael W Handlogten

Biotechnol Bioeng· January 2025

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Engineering redox sensors into CHO cells enables near-real-time quantification of intracellular redox in bioprocesses.
Kevin S McFarland, Jie Zhu, Pritam Sinharoy, Michael J Betenbaugh, Michael W Handlogten

Biotechnol Bioeng· June 2022

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Redox as a bioprocess parameter: analytical redox quantification in biological therapeutic production.
Pritam Sinharoy, Kevin S McFarland, Natalia I Majewska, Michael J Betenbaugh, Michael W Handlogten

Curr Opin Biotechnol· October 2021

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Prevention of Fab-arm exchange and antibody reduction via stabilization of the IgG4 hinge region.
Michael W Handlogten, Li Peng, Elizabeth A Christian, Weichen Xu, Shihua Lin

MAbs· July 2021

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Perfusion reduces bispecific antibody aggregation via mitigating mitochondrial dysfunction-induced glutathione oxidation and ER stress in CHO cells.
Pritam Sinharoy, Aaron H Aziz, Natalia I Majewska, Sanjeev Ahuja, Michael W Handlogten

Sci Rep· October 2020

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Online control of cell culture redox potential prevents antibody interchain disulfide bond reduction.
Michael W Handlogten, Jihong Wang, Sanjeev Ahuja

Biotechnol Bioeng· May 2020

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Impact of enzymatic reduction on bivalent bispecific antibody fragmentation and loss of product purity upon reoxidation.
Nicole Swope, Wai Keen Chung, Mingyan Cao, Dana Motabar, Dengfeng Liu, Michael Handlogten

Biotechnol Bioeng· April 2020

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Intracellular response to process optimization and impact on productivity and product aggregates for a high-titer CHO cell process.
Michael W Handlogten, Allison Lee-O'Brien, Gargi Roy, Sophia V Levitskaya, Raghavan Venkat

Biotechnol Bioeng· January 2018

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Glutathione and thioredoxin systems contribute to recombinant monoclonal antibody interchain disulfide bond reduction during bioprocessing.
Michael W Handlogten, Min Zhu, Sanjeev Ahuja

Biotechnol Bioeng· July 2017

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Effects of antibody disulfide bond reduction on purification process performance and final drug substance stability.
Wai Keen Chung, Brian Russell, Yanhong Yang, Michael Handlogten, Suzanne Hudak

Biotechnol Bioeng· June 2017

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What potential do heterobivalent inhibitors have for the treatment of severe allergic reactions?
Michael W Handlogten, Ana P Serezani, Mark H Kaplan, Basar Bilgicer

Immunotherapy· January 2015

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Two-allergen model reveals complex relationship between IgE crosslinking and degranulation.
Michael W Handlogten, Peter E Deak, Basar Bilgicer

Chem Biol· November 2014

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Affinity-based precipitation via a bivalent peptidic hapten for the purification of monoclonal antibodies.
Michael W Handlogten, Jared F Stefanick, Peter E Deak, Basar Bilgicer

Analyst· September 2014

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A heterobivalent ligand inhibits mast cell degranulation via selective inhibition of allergen-IgE interactions in vivo.
Michael W Handlogten, Ana P Serezani, Anthony L Sinn, Karen E Pollok, Mark H Kaplan

J Immunol· March 2014

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Inhibition of weak-affinity epitope-IgE interactions prevents mast cell degranulation.
Michael W Handlogten, Tanyel Kiziltepe, Ana P Serezani, Mark H Kaplan, Basar Bilgicer

Nat Chem Biol· December 2013

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Functionalized liposome purification via Liposome Extruder Purification (LEP).
Nathan J Alves, William Cusick, Jared F Stefanick, Jonathan D Ashley, Michael W Handlogten

Analyst· September 2013

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Selective photocrosslinking of functional ligands to antibodies via the conserved nucleotide binding site.
Nathan J Alves, Matthew M Champion, Jared F Stefanick, Michael W Handlogten, Demetri T Moustakas

Biomaterials· July 2013

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Nonchromatographic affinity precipitation method for the purification of bivalently active pharmaceutical antibodies from biological fluids.
Michael W Handlogten, Jared F Stefanick, Nathan J Alves, Basar Bilgicer

Anal Chem· May 2013

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Design of a heterotetravalent synthetic allergen that reflects epitope heterogeneity and IgE antibody variability to study mast cell degranulation.
Michael W Handlogten, Tanyel Kiziltepe, Basar Bilgicer

Biochem J· January 2013

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Synthetic allergen design reveals the significance of moderate affinity epitopes in mast cell degranulation.
Michael W Handlogten, Tanyel Kiziltepe, Nathan J Alves, Basar Bilgicer

ACS Chem Biol· November 2012

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Small-molecule-based affinity chromatography method for antibody purification via nucleotide binding site targeting.
Nathan J Alves, Samuel D Stimple, Michael W Handlogten, Jonathan D Ashley, Tanyel Kiziltepe

Anal Chem· September 2012

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Design of a heterobivalent ligand to inhibit IgE clustering on mast cells.
Michael W Handlogten, Tanyel Kiziltepe, Demetri T Moustakas, Başar Bilgiçer

Chem Biol· September 2011

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Harnessing structure-activity relationship to engineer a cisplatin nanoparticle for enhanced antitumor efficacy.
Abhimanyu S Paraskar, Shivani Soni, Kenneth T Chin, Padmaparna Chaudhuri, Katherine W Muto, Michael W Handlogten

Proc Natl Acad Sci U S A· July 2010

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