Publications by authors named "Michael Howell"

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Light-Activated Metal-Dependent Protein Degradation: A Heterobifunctional Ruthenium(II) Photosensitizer Targeting New Delhi Metallo-β-lactamase 1.
Lars Stevens-Cullinane, Thomas W Rees, Calum Evans, Po-Yu Ho, Mika Kintzel, Michael Howell

J Am Chem Soc· December 2025

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Hypoxic stress is an early pathogenic event in human VCP-mutant ALS astrocytes.
Hannah D Franklin, Hamish Crerar, Nishita Parnandi, Michael Lattke, Stanislaw Majewski, Michael Howell

Stem Cell Reports· December 2025

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The cis-regulatory logic integrating spatial and temporal patterning in the vertebrate neural tube.
Isabel Zhang, Giulia L M Boezio, Jake Cornwall-Scoones, Thomas Frith, Elizabeth Finnie, Michael Howell

Dev Cell· November 2025

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AI, Health, and Health Care Today and Tomorrow: The JAMA Summit Report on Artificial Intelligence.
Derek C Angus, Rohan Khera, Tracy Lieu, Vincent Liu, Faraz S Ahmad, Michael Howell

JAMA· November 2025

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The Need For Expanded Global Perspectives and Innovative Protocols With REM Sleep Behavior Disorder (RBD).
Carlos H Schenck, Michael J Howell

Sleep· November 2025

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High-Throughput Drug Screening in a Cellular Model of KRAS-Driven Arteriovenous Malformations.
Fanourios Michailidis, Davide Zecchin, Mohammad Rabii, Ignacio Del Valle Torres, Aimie Sauvadet, Michael Howell

J Invest Dermatol· October 2025

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The essential host genome for Cryptosporidium survival exposes metabolic dependencies that can be leveraged for treatment.
N Bishara Marzook, Ok-Ryul Song, Lotta Baumgärtel, Netanya Bernitz, Tapoka T Mkandawire, Michael Howell

Cell· October 2025

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Accelerated Progression of Gait Impairment in Parkinson's Disease and REM Sleep Without Atonia.
Sommer L Amundsen-Huffmaster, Jae Woo Chung, Maria E Linn-Evans, Matthew N Petrucci, Chiahao Lu, Michael J Howell

Ann Clin Transl Neurol· October 2025

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EXO1 as a therapeutic target for Fanconi Anaemia, ZRSR2 and BRCA1-A complex deficient cancers.
Marija Maric, Sandra Segura-Bayona, Raviprasad Kuthethur, Tohru Takaki, Valerie Borel, Michael Howell

Nat Commun· September 2025

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Post-gastrulation amnioids as a stem cell-derived model of human extra-embryonic development.
Borzo Gharibi, Oliver C K Inge, Irene Rodriguez-Hernandez, Paul C Driscoll, Christelle Dubois, Michael Howell

Cell· July 2025

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The DNA replication checkpoint prevents PCNA/RFC depletion to protect forks from HLTF-induced collapse in human cells.
Agostina P Bertolin, Berta Canal, Mona Yekezare, Anne Early, Jingkun Zeng, Michael Howell

Mol Cell· July 2025

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Association of Physical Activity from Wearable Devices and Chronic Disease Risk: Insights from the All of Us Research Program.
Rui Zhang, Yu Hou, Erjia Cui, Kelvin Lim, Lisa Chow, Michael Howell

Res Sq· May 2025

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Systematic genetic perturbation reveals principles underpinning robustness of the epigenetic regulatory network.
Thomas Stuart Wilson, Roberta Noberini, Eirini Moysidou, Ifeyinwa Ojukwu, Marta Milan, Michael Howell

Nucleic Acids Res· April 2025

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TRACERx analysis identifies a role for FAT1 in regulating chromosomal instability and whole-genome doubling via Hippo signalling.
Wei-Ting Lu, Lykourgos-Panagiotis Zalmas, Chris Bailey, James R M Black, Carlos Martinez-Ruiz, Michael Howell

Nat Cell Biol· January 2025

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Safety principles for medical summarization using generative AI.
Dillon Obika, Christopher Kelly, Nicola Ding, Chris Farrance, Jonathan Krause, Michael Howell

Nat Med· December 2024

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Comparison of Tape-Stripping Platforms as Noninvasive Solutions for Skin Biomarker Discovery.
Erica N Montano, Ailyn Tapia, Michael D Howell, Jelena Ostojić

J Invest Dermatol· November 2024

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Cognitive, motor, and autonomic function among individuals with serotonergic versus isolated rapid eye movement sleep behavior disorder.
Neha V Reddy, Meaghan Berns, Rachael Berns, Hannah Olson, Erija Cui, Michael Howell

Sleep· November 2024

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IGLON5 Frequency in Idiopathic REM Sleep Behavior Disorder: A Multicenter Study.
Ronald Postuma, Nisa Vorasoot, Erik K St Louis, Amélie Pelletier, Miranda M Lim, Michael Howell

Neurol Neuroimmunol Neuroinflamm· November 2024

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Human VCP mutant ALS/FTD microglia display immune and lysosomal phenotypes independently of GPNMB.
Benjamin E Clarke, Oliver J Ziff, Giulia Tyzack, Marija Petrić Howe, Yiran Wang, Michael Howell

Mol Neurodegener· November 2024

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Generative artificial intelligence, patient safety and healthcare quality: a review.
Michael D Howell

BMJ Qual Saf· October 2024

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CARD14 signalosome formation is associated with its endosomal relocation and mTORC1-induced keratinocyte proliferation.
Paul A O'Sullivan, Aigerim Aidarova, Inna S Afonina, Joan Manils, Teresa L M Thurston, Michael Howell

Biochem J· September 2024

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Antibacterial activity of Au(I), Pt(II), and Ir(III) biotin conjugates prepared by the iClick reaction: influence of the metal coordination sphere on the biological activity.
Dominik Moreth, Lars Stevens-Cullinane, Thomas W Rees, Victoria V L Müller, Adrien Pasquier, Michael Howell

J Biol Inorg Chem· September 2024

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Non-STEM majors COVID-19 vaccine impressions improve, and misconceptions resolve, after podcast assignment.
Christina N Morra, Sarah J Adkins, M Elizabeth Barnes, Obadiah J Pirlo, Ryleigh Fleming, Michael L Howell

J Microbiol Biol Educ· August 2024

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Slow-wave sleep dysfunction in mild parkinsonism is associated with excessive beta and reduced delta oscillations in motor cortex.
Ajay K Verma, Bharadwaj Nandakumar, Kit Acedillo, Ying Yu, Ethan Marshall, Michael J Howell

Front Neurosci· February 2024

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Three Epochs of Artificial Intelligence in Health Care.
Michael D Howell, Greg S Corrado, Karen B DeSalvo

JAMA· January 2024

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