Publications by authors named "Michael Leiss"

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Rapid At-Line AAVX Affinity HPLC: Enabling Process Analytical Technology for Bioprocess Development of Adeno-Associated Virus Vectors.
Jakob Heckel, Timo Bohlig, Lea Bonnington, Michael Leiss, Markus Haindl

Biotechnol J· March 2025

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Establishing Multi-Dimensional LC-MS Systems for Versatile Workflows to Analyze Therapeutic Antibodies at Different Molecular Levels in Routine Operations.
Katrin Heinrich, Sina Hoelterhoff, Saban Oezipek, Martin Winter, Tobias Rainer, Michael Leiss

Pharmaceuticals (Basel)· March 2025

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Expediting online liquid chromatography for real-time monitoring of product attributes to advance process analytical technology in downstream processing of biopharmaceuticals.
Tobias Graf, Lukas Naumann, Lea Bonnington, Jakob Heckel, Bernhard Spensberger, Michael Leiss

J Chromatogr A· August 2024

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Fast HPLC-based affinity method to determine capsid titer and full/empty ratio of adeno-associated viral vectors.
Jakob Heckel, Andres Martinez, Carsten Elger, Markus Haindl, Michael Leiss

Mol Ther Methods Clin Dev· December 2023

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Effects of Different Container Types on (1→3)-β-D-glucan Recovery.
Luisa Burgmaier, Bernhard Illes, Michael Leiss, Meltem Avci-Adali, Johannes Reich

Molecules· October 2023

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A fast and sensitive high-throughput assay to assess polysorbate-degrading hydrolytic activity in biopharmaceuticals.
Sanjay K Gupta, Tobias Graf, Franziska T Edelmann, Helen Seelmann, Markus Reintinger, Michael Leiss

Eur J Pharm Biopharm· June 2023

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Industry Perspective on the Use and Characterization of Polysorbates for Biopharmaceutical Products Part 2: Survey Report on Control Strategy Preparing for the Future.
Klaus Wuchner, Linda Yi, Cyrille Chery, Felix Nikels, Friederike Junge, Michael Leiss

J Pharm Sci· November 2022

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Industry Perspective on the use and Characterization of Polysorbates for Biopharmaceutical Products Part 1: Survey Report on Current State and Common Practices for Handling and Control of Polysorbates.
Klaus Wuchner, Linda Yi, Cyrille Chery, Felix Nikels, Friederike Junge, Michael Leiss

J Pharm Sci· May 2022

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Detailed Analytical Characterization of a Bispecific IgG1 CrossMab Antibody of the Knob-into-Hole Format Applying Various Stress Conditions Revealed Pronounced Stability.
Ingrid Grunert, Katrin Heinrich, Juliane Ernst, Michael Hingar, Alexandre Briguet, Michael Leiss

ACS Omega· February 2022

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Identification and Characterization of Polysorbate-Degrading Enzymes in a Monoclonal Antibody Formulation.
Tobias Graf, Anthony Tomlinson, Inn H Yuk, Regina Kufer, Bernhard Spensberger, Michael Leiss

J Pharm Sci· November 2021

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Inter-laboratory study to evaluate the performance of automated online characterization of antibody charge variants by multi-dimensional LC-MS/MS.
Julien Camperi, Ingrid Grunert, Katrin Heinrich, Martin Winter, Saban Özipek, Michael Leiss

Talanta· November 2021

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Fast analysis of antibody-derived therapeutics by automated multidimensional liquid chromatography - Mass spectrometry.
Sanne Pot, Christoph Gstöttner, Katrin Heinrich, Sina Hoelterhoff, Ingrid Grunert, Michael Leiss

Anal Chim Acta· November 2021

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Recent advances in LC-MS based characterization of protein-based bio-therapeutics - mastering analytical challenges posed by the increasing format complexity.
Tobias Graf, Katrin Heinrich, Ingrid Grunert, Harald Wegele, Markus Haberger, Michael Leiss

J Pharm Biomed Anal· July 2020

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Controlled polysorbate 20 hydrolysis - A new approach to assess the impact of polysorbate 20 degradation on biopharmaceutical product quality in shortened time.
Tobias Graf, Kathrin Abstiens, Frank Wedekind, Carsten Elger, Markus Haindl, Michael Leiss

Eur J Pharm Biopharm· July 2020

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From proof of concept to the routine use of an automated and robust multi-dimensional liquid chromatography mass spectrometry workflow applied for the charge variant characterization of therapeutic antibodies.
Alexandre Goyon, Lu Dai, Tao Chen, Bingchuan Wei, Feng Yang, Michael Leiss

J Chromatogr A· March 2020

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Rapid characterization of biotherapeutic proteins by size-exclusion chromatography coupled to native mass spectrometry.
Markus Haberger, Michael Leiss, Anna-Katharina Heidenreich, Oxana Pester, Georg Hafenmair

MAbs· December 2016

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Formation and activation of fibroblast spheroids depend on fibronectin-integrin interaction.
Pertteli Salmenperä, Esko Kankuri, Jozef Bizik, Vappu Sirén, Ismo Virtanen, Michael Leiss

Exp Cell Res· November 2008

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The role of integrin binding sites in fibronectin matrix assembly in vivo.
Michael Leiss, Karsten Beckmann, Amparo Girós, Mercedes Costell, Reinhard Fässler

Curr Opin Cell Biol· October 2008

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The RGD motif in fibronectin is essential for development but dispensable for fibril assembly.
Seiichiro Takahashi, Michael Leiss, Markus Moser, Tomoo Ohashi, Tomoe Kitao

J Cell Biol· July 2007

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