Publications by authors named "Michael Ohh"

Claim this Profile
E
Erythrocytosis-inducing PHD2 mutations implicate biological role for N-terminal prolyl-hydroxylation in HIF1α oxygen-dependent degradation domain.
Cassandra C Taber, Wenguang He, Geneviève M C Gasmi-Seabrook, Mia Hubert, Fraser G Ferens, Michael Ohh

Elife· October 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Comparative single-cell transcriptomic profiling of patient-derived renal carcinoma cells in cellular and animal models of kidney cancer.
Richard Huang, Lynn Kee, Alexander Gont, Jalna Meens, Fraser G Ferens, Michael Ohh

FEBS Open Bio· July 2025

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
G
Glucose deprivation impairs hypoxia-inducible factor-1α synthesis.
Mia Hubert, Sarah Stuart, Michael Ohh

Discov Oncol· October 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Time-resolved NMR detection of prolyl-hydroxylation in intrinsically disordered region of HIF-1α.
Wenguang He, Geneviève M C Gasmi-Seabrook, Mitsuhiko Ikura, Jeffrey E Lee, Michael Ohh

Proc Natl Acad Sci U S A· September 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Cathepsins L and B target HIF1α for oxygen-independent proteolytic cleavage.
Sarah Stuart, Daniel Tarade, Michael Ohh

Sci Rep· June 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Deficiency in PHD2-mediated hydroxylation of HIF2α underlies Pacak-Zhuang syndrome.
Fraser G Ferens, Cassandra C Taber, Sarah Stuart, Mia Hubert, Daniel Tarade, Michael Ohh

Commun Biol· February 2024

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
SHP2 Inhibition with TNO155 Increases Efficacy and Overcomes Resistance of ALK Inhibitors in Neuroblastoma.
Ivette Valencia-Sama, Lynn Kee, Gabriella Christopher, Michael Ohh, Mehdi Layeghifard

Cancer Res Commun· December 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
O
Oxidized Low-Density Lipoprotein Accumulation Suppresses Glycolysis and Attenuates the Macrophage Inflammatory Response by Diverting Transcription from the HIF-1α to the Nrf2 Pathway.
Kenneth K Y Ting, Pei Yu, Riley Dow, Eric Floro, Hisham Ibrahim, Michael Ohh

J Immunol· November 2023

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
Hypoxia-inducible factor underlies von Hippel-Lindau disease stigmata.
Michael Ohh, Cassandra C Taber, Fraser G Ferens, Daniel Tarade

Elife· August 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
D154Q Mutation does not Alter KRAS Dimerization.
Ingrid Grozavu, Sarah Stuart, Anna Lyakisheva, Zhong Yao, Shivanthy Pathmanathan, Michael Ohh

J Mol Biol· January 2022

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
S
Side population analysis in clear cell renal cell carcinoma.
Richard Huang, Jalna Meens, Scott Yuzwa, Laurie Ailles, Michael Ohh

Biochem Biophys Res Commun· December 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
HIF-1α Hydroxyprolines Modulate Oxygen-Dependent Protein Stability Via Single VHL Interface With Comparable Effect on Ubiquitination Rate.
Wenguang He, Sarah Batty-Stuart, Jeffrey E Lee, Michael Ohh

J Mol Biol· November 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The Q61H mutation decouples KRAS from upstream regulation and renders cancer cells resistant to SHP2 inhibitors.
Teklab Gebregiworgis, Yoshihito Kano, Jonathan St-Germain, Nikolina Radulovich, Molly L Udaskin, Michael Ohh

Nat Commun· November 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
Hypoxia and viral infectious diseases.
Richard Huang, Melissa Huestis, Esther Shuyi Gan, Eng Eong Ooi, Michael Ohh

JCI Insight· April 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
P
PD-1 blockade delays tumor growth by inhibiting an intrinsic SHP2/Ras/MAPK signalling in thyroid cancer cells.
Federica Liotti, Narender Kumar, Nella Prevete, Maria Marotta, Daniela Sorriento, Michael Ohh

J Exp Clin Cancer Res· January 2021

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
N
Nucleolar RNA polymerase II drives ribosome biogenesis.
Karan J Abraham, Negin Khosraviani, Janet N Y Chan, Aparna Gorthi, Anas Samman, Michael Ohh

Nature· September 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
The long form of pVHL is artifactually modified by serine protease inhibitor AEBSF.
Daniel Tarade, Shelley He, Jonathan St-Germain, Avi Petroff, Anya Murphy, Michael Ohh

Protein Sci· August 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
Status Determines Sensitivity to SHP2 Inhibitor Combination Therapies Targeting the RAS-MAPK Pathway in Neuroblastoma.
Ivette Valencia-Sama, Yagnesh Ladumor, Lynn Kee, Teresa Adderley, Gabriella Christopher, Michael Ohh

Cancer Res· August 2020

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
A
A Hypoxia-Inducible HIF1-GAL3ST1-Sulfatide Axis Enhances ccRCC Immune Evasion via Increased Tumor Cell-Platelet Binding.
Claire M Robinson, Betty P K Poon, Yoshihito Kano, Fred G Pluthero, Walter H A Kahr, Michael Ohh

Mol Cancer Res· November 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
E
Evolution of metazoan oxygen-sensing involved a conserved divergence of VHL affinity for HIF1α and HIF2α.
Daniel Tarade, Jeffrey E Lee, Michael Ohh

Nat Commun· July 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
D
Disturbed Flow Increases UBE2C (Ubiquitin E2 Ligase C) via Loss of miR-483-3p, Inducing Aortic Valve Calcification by the pVHL (von Hippel-Lindau Protein) and HIF-1α (Hypoxia-Inducible Factor-1α) Pathway in Endothelial Cells.
Joan Fernandez Esmerats, Nicolas Villa-Roel, Sandeep Kumar, Lina Gu, Md Tausif Salim, Michael Ohh

Arterioscler Thromb Vasc Biol· March 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Tyrosyl phosphorylation of KRAS stalls GTPase cycle via alteration of switch I and II conformation.
Yoshihito Kano, Teklab Gebregiworgis, Christopher B Marshall, Nikolina Radulovich, Betty P K Poon, Michael Ohh

Nat Commun· January 2019

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
T
Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides.
Laura Hulea, Simon-Pierre Gravel, Masahiro Morita, Marie Cargnello, Oro Uchenunu, Michael Ohh

Cell Metab· December 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
H
HIF-2α-pVHL complex reveals broad genotype-phenotype correlations in HIF-2α-driven disease.
Daniel Tarade, Claire M Robinson, Jeffrey E Lee, Michael Ohh

Nat Commun· August 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis
C
Consequences of VHL Loss on Global DNA Methylome.
Claire M Robinson, Francois Lefebvre, Betty P Poon, Aurelie Bousard, Xiaojun Fan, Michael Ohh

Sci Rep· February 2018

Social Media Activity not collected for this article yet.

Sign Up to Request Social Media Analysis