Publications by authors named "Michael Ohlmeyer"

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Small molecule activator of phosphatase PP2A remodels scaffold PR65 structural dynamics to promote holoenzyme assembly.
Sema Z Yilmaz, Anupam Banerjee, Satyaki Saha, Michael Ohlmeyer, Reuven Gordon

bioRxiv· November 2025

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The Emerging Role of the Cancerous Inhibitor of Protein Phosphatase 2A in Pulmonary Diseases.
Hamza Hamza, Dinesh Nirmal, Stephanie Pappas, Ugochukwu Ebubechukwu, Sunydip Gill, Michael Ohlmeyer

Medicina (Kaunas)· September 2025

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Small Molecule Activators of Protein Phosphatase 2A Exert Global Stabilising Effects on the Scaffold PR65.
Mohsin M Naqvi, Maria Zacharopoulou, Satyaki Saha, Anupam Banerjee, Zeynep S Yilmaz, Michael Ohlmeyer

bioRxiv· July 2025

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Direct observation of small molecule activator binding to single PR65 protein.
Annie Yang-Schulz, Maria Zacharopoulou, Sema Zeynep Yilmaz, Anupam Banerjee, Satyaki Saha, Michael Ohlmeyer

NPJ Biosens· January 2025

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PP2A activation overcomes leptomeningeal dissemination in group 3 medulloblastoma.
Nazia Nazam, Michael H Erwin, Janet R Julson, Colin H Quinn, Andee M Beierle, Michael Ohlmeyer

J Biol Chem· November 2024

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Novel PP2A-Activating Compounds in Neuroblastoma.
Nazia Nazam, Laura V Bownes, Janet R Julson, Colin H Quinn, Michael H Erwin, Michael Ohlmeyer

Cancers (Basel)· November 2024

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Evaluating Novel Protein Phosphatase 2A Activators as Therapeutics for Emphysema.
Brian Soto, Huma Ahmed, Meshach Pillai, Sangmi S Park, Magdalena Ploszaj, Michael Ohlmeyer

Am J Respir Cell Mol Biol· November 2023

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Small-Molecule Activation of Protein Phosphatase 2A Counters Bleomycin-Induced Fibrosis in Mice.
Meshach Pillai, Pascale Lafortune, Abdoulaye Dabo, Howard Yu, Sangmi S Park, Michael Ohlmeyer

ACS Pharmacol Transl Sci· November 2023

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PP2A-based triple-strike therapy overcomes mitochondrial apoptosis resistance in brain cancer cells.
Oxana V Denisova, Joni Merisaari, Riikka Huhtaniemi, Xi Qiao, Laxman Yetukuri, Michael Ohlmeyer

Mol Oncol· September 2023

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Protein Phosphatase 2A as a Therapeutic Target in Pulmonary Diseases.
Howard Yu, Sahil Zaveri, Zeeshan Sattar, Michael Schaible, Brais Perez Gandara, Michael Ohlmeyer

Medicina (Kaunas)· August 2023

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The Effects of Protein Phosphatase 2A Activation with Novel Tricyclic Sulfonamides on Hepatoblastoma.
Laura V Bownes, Janet R Julson, Colin H Quinn, Sara Claire Hutchins, Michael H Erwin, Michael Ohlmeyer

J Pediatr Surg· June 2023

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Rapid Characterization of Solid Tumors Using Resonant Sensors.
Andee M Beierle, Colin H Quinn, Hooper R Markert, Adam Carr, Raoud Marayati, Michael Ohlmeyer

ACS Omega· September 2022

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Development of actionable targets of multi-kinase inhibitors (AToMI) screening platform to dissect kinase targets of staurosporines in glioblastoma cells.
Oxana V Denisova, Joni Merisaari, Amanpreet Kaur, Laxman Yetukuri, Mikael Jumppanen, Michael Ohlmeyer

Sci Rep· August 2022

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Pre-Clinical Study Evaluating Novel Protein Phosphatase 2A Activators as Therapeutics for Neuroblastoma.
Laura V Bownes, Raoud Marayati, Colin H Quinn, Andee M Beierle, Sara C Hutchins, Michael Ohlmeyer

Cancers (Basel)· April 2022

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TBK1 and IKKε act like an OFF switch to limit NLRP3 inflammasome pathway activation.
Fabian A Fischer, Linda F M Mies, Sohaib Nizami, Eirini Pantazi, Sara Danielli, Michael Ohlmeyer

Proc Natl Acad Sci U S A· September 2021

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The PP2A-Integrator-CDK9 axis fine-tunes transcription and can be targeted therapeutically in cancer.
Stephin J Vervoort, Sarah A Welsh, Jennifer R Devlin, Elisa Barbieri, Deborah A Knight, Michael Ohlmeyer

Cell· June 2021

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Direct Activation of Protein Phosphatase 2A (PP2A) by Tricyclic Sulfonamides Ameliorates Alzheimer's Disease Pathogenesis in Cell and Animal Models.
Hui Wei, Hui-Liang Zhang, Xiao-Chuan Wang, Jia-Zhao Xie, Dan-Dan An, Michael Ohlmeyer

Neurotherapeutics· July 2020

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Unbiased Proteomic Profiling Uncovers a Targetable GNAS/PKA/PP2A Axis in Small Cell Lung Cancer Stem Cells.
Garry L Coles, Sandra Cristea, James T Webber, Rebecca S Levin, Steven M Moss, Michael Ohlmeyer

Cancer Cell· July 2020

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Monotherapy efficacy of blood-brain barrier permeable small molecule reactivators of protein phosphatase 2A in glioblastoma.
Joni Merisaari, Oxana V Denisova, Milena Doroszko, Vadim Le Joncour, Patrik Johansson, Michael Ohlmeyer

Brain Commun· January 2020

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Reply: Relevance of the PP2A Pathway in the Molecular Mechanisms of Chronic Obstructive Pulmonary Disease.
Sridesh Nath, Michael Ohlmeyer, Matthias A Salathe, Justin Poon, Nathalie Baumlin

Am J Respir Cell Mol Biol· November 2019

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Protein phosphatase 2A as a therapeutic target in inflammation and neurodegeneration.
Andrew R Clark, Michael Ohlmeyer

Pharmacol Ther· September 2019

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Protein Phosphatase 2A Reduces Cigarette Smoke-induced Cathepsin S and Loss of Lung Function.
Declan F Doherty, Sridesh Nath, Justin Poon, Robert F Foronjy, Michael Ohlmeyer

Am J Respir Crit Care Med· July 2019

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Direct activation of PP2A for the treatment of tyrosine kinase inhibitor-resistant lung adenocarcinoma.
Rita Tohmé, Sudeh Izadmehr, Sai Gandhe, Giancarlo Tabaro, Sanjay Vallabhaneni, Michael Ohlmeyer

JCI Insight· February 2019

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Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocarcinoma.
Brittany L Allen-Petersen, Tyler Risom, Zipei Feng, Zhiping Wang, Zina P Jenny, Michael Ohlmeyer

Cancer Res· January 2019

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Inhibitor of CBP Histone Acetyltransferase Downregulates p53 Activation and Facilitates Methylation at Lysine 27 on Histone H3.
Adam S Vincek, Jigneshkumar Patel, Anbalagan Jaganathan, Antonia Green, Valerie Pierre-Louis, Michael Ohlmeyer

Molecules· August 2018

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