Publications by authors named "Michael Ostrowski"

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Hepatic protein kinase Cβ antagonizing p38 to activate ERK1/2 to dysregulate biliary lipid composition upon lithogenic stress.
Yaoling Shu, Amit Rai, Gina M Sizemore, Michael Ostrowski, Wei Huang

Am J Physiol Gastrointest Liver Physiol· December 2025

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Secreted frizzled-related protein 2 monoclonal antibody-mediated IFN-ϒ reprograms tumor-associated macrophages to suppress triple negative breast cancer.
Lillian Hsu, Julie Siegel, Patrick Nasarre, Nathaniel Oberholtzer, Rupak Mukherjee, Michael Ostrowski

Breast Cancer Res· December 2025

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Biliverdin reductase A is a major determinant of protective NRF2 signaling.
Chirag Vasavda, Ruchita Kothari, Navneet Ammal Kaidery, Suwarna Chakraborty, Sunil Jamuna Tripathi, Michael C Ostrowski

Proc Natl Acad Sci U S A· October 2025

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Erratum: Randomized Phase II Study of Nab-Paclitaxel and Gemcitabine With or Without Tocilizumab as First-Line Treatment in Advanced Pancreatic Cancer: Survival and Cachexia.
Inna M Chen, Julia S Johansen, Susann Theile, Libbie M Silverman, Katherine R Pelz, Michael C Ostrowski

J Clin Oncol· September 2025

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Pancreatic Cancer Induces Population-Specific Switching of Myosin Isoforms and Discrete Activation of Cachexia Genes in Skeletal Muscle Myocytes.
Brittany R Counts, Sephora Jean, Omnia Gaafer, Sara K Ota, Iishaan Inabathini, Michael C Ostrowski

bioRxiv· September 2025

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Biliverdin Reductase A is a major determinant of neuroprotective Nrf2 signaling.
Chirag Vasavda, Ruchita Kothari, Navneet Ammal Kaidery, Suwarna Chakraborty, Sunil Jamuna Tripathi, Michael C Ostrowski

bioRxiv· August 2025

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Randomized Phase II Study of Nab-Paclitaxel and Gemcitabine With or Without Tocilizumab as First-Line Treatment in Advanced Pancreatic Cancer: Survival and Cachexia.
Inna M Chen, Julia S Johansen, Susann Theile, Libbie M Silverman, Katherine R Pelz, Michael C Ostrowski

J Clin Oncol· June 2025

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Profiling of collagen and extracellular matrix deposition from cell culture using in vitro ExtraCellular matrix mass spectrometry imaging (ivECM-MSI).
Stephen C Zambrzycki, Samaneh Saberi, Rachel Biggs, Najmeh Eskandari, Davide Delisi, Michael Ostrowski

Matrix Biol Plus· December 2024

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Muscle inflammation is regulated by NF-κB from multiple cells to control distinct states of wasting in cancer cachexia.
Benjamin R Pryce, Alexander Oles, Erin E Talbert, Martin J Romeo, Silvia Vaena, Michael C Ostrowski

Cell Rep· November 2024

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Optimization of a mouse model of pancreatic cancer to simulate the human phenotypes of metastasis and cachexia.
Victoria Spadafora, Benjamin R Pryce, Alexander Oles, Erin E Talbert, Martin Romeo, Michael C Ostrowski

BMC Cancer· April 2024

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The impact of inflammation and acute phase activation in cancer cachexia.
Tyler P Robinson, Tewfik Hamidi, Brittany Counts, Denis C Guttridge, Michael C Ostrowski

Front Immunol· December 2023

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Pubertal exposure to dietary advanced glycation end products disrupts ductal morphogenesis and induces atypical hyperplasia in the mammary gland.
Bradley A Krisanits, Reid Schuster, Jaime Randise, Lourdes M Nogueira, Jackson T Lane, Michael C Ostrowski

Breast Cancer Res· October 2023

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Hepatic protein kinase Cbeta deficiency mitigates late-onset obesity.
Yaoling Shu, Nikhil Gumma, Faizule Hassan, Daniel A Branch, Lisa A Baer, Michael C Ostrowski

J Biol Chem· August 2023

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Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors.
Padma Akkapeddi, Takamitsu Hattori, Imran Khan, Eliezra Glasser, Akiko Koide, Michael C Ostrowski

Proc Natl Acad Sci U S A· July 2023

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Cancer cachexia: involvement of an expanding macroenvironment.
Benjamin R Pryce, David J Wang, Teresa A Zimmers, Michael C Ostrowski, Denis C Guttridge

Cancer Cell· March 2023

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The splanchnic mesenchyme is the tissue of origin for pancreatic fibroblasts during homeostasis and tumorigenesis.
Lu Han, Yongxia Wu, Kun Fang, Sean Sweeney, Ulyss K Roesner, Michael C Ostrowski

Nat Commun· January 2023

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STAT3 in tumor fibroblasts promotes an immunosuppressive microenvironment in pancreatic cancer.
Julia E Lefler, Catherine B MarElia-Bennett, Katie A Thies, Blake E Hildreth, Sudarshana M Sharma, Michael C Ostrowski

Life Sci Alliance· November 2022

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Stromal p53 Regulates Breast Cancer Development, the Immune Landscape, and Survival in an Oncogene-Specific Manner.
Jinghai Wu, Xin Liu, Julie A Wallace Reeser, Anthony J Trimboli, Thierry Pécot, Michael C Ostrowski

Mol Cancer Res· August 2022

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Origin, activation and heterogeneity of fibroblasts associated with pancreas and breast cancers.
Lu Han, Cara Seward, Gustavo Leone, Michael C Ostrowski

Adv Cancer Res· April 2022

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PTEN in cancer associated fibroblasts.
Julia E Lefler, Cara Seward, Michael C Ostrowski

Adv Cancer Res· April 2022

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Preface.
Peggi M Angel, Michael C Ostrowski

Adv Cancer Res· April 2022

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Role of hepatic PKCβ in nutritional regulation of hepatic glycogen synthesis.
Yaoling Shu, Faizule Hassan, Michael C Ostrowski, Kamal D Mehta

JCI Insight· October 2021

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Defining the Tumor Microenvironment by Integration of Immunohistochemistry and Extracellular Matrix Targeted Imaging Mass Spectrometry.
Denys Rujchanarong, Julia Lefler, Janet E Saunders, Sarah Pippin, Laura Spruill, Michael C Ostrowski

Cancers (Basel)· September 2021

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PRMT5-mediated arginine methylation activates AKT kinase to govern tumorigenesis.
Shasha Yin, Liu Liu, Charles Brobbey, Viswanathan Palanisamy, Lauren E Ball, Michael C Ostrowski

Nat Commun· June 2021

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The small G-protein RalA promotes progression and metastasis of triple-negative breast cancer.
Katie A Thies, Matthew W Cole, Rachel E Schafer, Jonathan M Spehar, Dillon S Richardson, Michael C Ostrowski

Breast Cancer Res· June 2021

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