Publications by authors named "Michael Otteneder"

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Innate immune response to AAV-based gene therapy vectors: Mechanisms of complement activation and cytokine release.
Rebecca Xicluna, Petra C Schwalie, Emma Bell, Desiree Von Tell, Guido Steiner, Michael B Otteneder

Mol Ther Methods Clin Dev· September 2025

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Preclinical B cell depletion and safety profile of a brain-shuttled crystallizable fragment-silenced CD20 antibody.
Vanessa L Schumacher, Solen Pichereau, Juliana Bessa, Juergen Bachl, Sylvia Herter, Michael B Otteneder

Clin Transl Med· March 2025

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A Brief Review of Radiolabelling Nucleic Acid-Based Molecules for Tracking and Monitoring.
Martin R Edelmann, Filippo Sladojevich, Stephen M Husbands, Michael B Otteneder, Ian S Blagbrough

J Labelled Comp Radiopharm· November 2024

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Biodistribution of Drug/ADA Complexes: The Impact of Immune Complex Formation on Antibody Distribution.
Eugenia Opolka-Hoffmann, Martin R Edelmann, Michael B Otteneder, Simon Hauri, Gregor Jordan

AAPS J· March 2024

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Investigating brain uptake of a non-targeting monoclonal antibody after intravenous and intracerebroventricular administration.
Arthur J Van De Vyver, Antje-Christine Walz, Mariette S Heins, Afsaneh Abdolzade-Bavil, Thomas E Kraft, Michael B Otteneder

Front Pharmacol· August 2022

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The impact of immunogenicity on therapeutic antibody pharmacokinetics: A preclinical evaluation of the effect of immune complex formation and antibody effector function on clearance.
Eugenia Opolka-Hoffmann, Gregor Jordan, Michael Otteneder, Robin Kieferle, Martin Lechmann

MAbs· April 2022

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Pharmacokinetics and Determination of Tumor Interstitial Distribution of a Therapeutic Monoclonal Antibody Using Large-Pore Microdialysis.
Vipada Khaowroongrueng, Satyawan B Jadhav, Muzeeb Syed, Mohammad Akbar, Michael Gertz, Michael B Otteneder

J Pharm Sci· August 2021

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Radiolabeled IgG antibodies: Impact of various labels on neonatal Fc receptor binding.
Martin R Edelmann, Hubert Kettenberger, Alexander Knaupp, Tilman Schlothauer, Michael B Otteneder

J Labelled Comp Radiopharm· September 2019

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Nanotracing and cavity-ring down spectroscopy: A new ultrasensitive approach in large molecule drug disposition studies.
Nicole A Kratochwil, Stephen R Dueker, Dieter Muri, Claudia Senn, HyeJin Yoon, Michael B Otteneder

PLoS One· March 2019

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High-Throughput, Sensitive LC-MS Quantification of Biotherapeutics and Biomarkers Using Antibody-Free, Peptide-Level, Multiple-Mechanism Enrichment via Strategic Regulation of pH and Ionic and Solvent Strengths.
Bo An, Ming Zhang, Jie Pu, Shichen Shen, Yang Qu, Michael B Otteneder

Anal Chem· March 2019

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"Catch-and-Release" Anti-Carcinoembryonic Antigen Monoclonal Antibody Leads to Greater Plasma and Tumor Exposure in a Mouse Model of Colorectal Cancer.
Frank A Engler, Joseph Ryan Polli, Tommy Li, Bo An, Michael Otteneder

J Pharmacol Exp Ther· July 2018

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Interstitial IgG antibody pharmacokinetics assessed by combined in vivo- and physiologically-based pharmacokinetic modelling approaches.
Miro J Eigenmann, Tine V Karlsen, Ben-Fillippo Krippendorff, Olav Tenstad, Ludivine Fronton, Michael B Otteneder

J Physiol· December 2017

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Tissue Distribution of a Therapeutic Monoclonal Antibody Determined by Large Pore Microdialysis.
Satyawan B Jadhav, Vipada Khaowroongrueng, Matthias Fueth, Michael B Otteneder, Wolfgang Richter

J Pharm Sci· September 2017

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Toward in vitro-to-in vivo translation of monoclonal antibody pharmacokinetics: Application of a neonatal Fc receptor-mediated transcytosis assay to understand the interplaying clearance mechanisms.
Claudia A Castro Jaramillo, Sara Belli, Anne-Christine Cascais, Sherri Dudal, Martin R Edelmann, Michael B Otteneder

MAbs· July 2017

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Minipig and Human Metabolism of Aldehyde Oxidase Substrates: In Vitro-In Vivo Comparisons.
David J Wilkinson, Rosalind L Southall, Mingguang Li, Lisa M Wright, Lindsay J Corfield, Michael B Otteneder

AAPS J· July 2017

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Distribution of FcRn Across Species and Tissues.
Sari Latvala, Bjoern Jacobsen, Michael B Otteneder, Annika Herrmann, Sven Kronenberg

J Histochem Cytochem· June 2017

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Quantification of IgG monoclonal antibody clearance in tissues.
Miro J Eigenmann, Ludivine Fronton, Hans Peter Grimm, Michael B Otteneder, Ben-Fillippo Krippendorff

MAbs· June 2017

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Erratum to: Characterization of Pharmacokinetics in the Göttingen Minipig with Reference Human Drugs: An In Vitro and In Vivo Approach.
Floriane Lignet, Eva Sherbetjian, Nicole Kratochwil, Russell Jones, Claudia Suenderhauf, Michael B Otteneder

Pharm Res· November 2016

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Characterization of Pharmacokinetics in the Göttingen Minipig with Reference Human Drugs: An In Vitro and In Vivo Approach.
Floriane Lignet, Eva Sherbetjian, Nicole Kratochwil, Russell Jones, Claudia Suenderhauf, Michael B Otteneder

Pharm Res· October 2016

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Minipig as a potential translatable model for monoclonal antibody pharmacokinetics after intravenous and subcutaneous administration.
Yanan Zheng, Devin B Tesar, Lisa Benincosa, Herbert Birnböck, C Andrew Boswell, Michael Otteneder

MAbs· February 2015

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Role of the intestinal peptide transporter PEPT1 in oseltamivir absorption: in vitro and in vivo studies.
Agnès Poirier, Sara Belli, Christoph Funk, Michael B Otteneder, Renée Portmann

Drug Metab Dispos· August 2012

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Discovery of a factor Xa inhibitor (3R,4R)-1-(2,2-difluoro-ethyl)-pyrrolidine-3,4-dicarboxylic acid 3-[(5-chloro-pyridin-2-yl)-amide] 4-[[2-fluoro-4-(2-oxo-2H-pyridin-1-yl)-phenyl]-amide] as a clinical candidate.
Lilli Anselm, David W Banner, Jörg Benz, Katrin Groebke Zbinden, Jacques Himber, Michael B Otteneder

Bioorg Med Chem Lett· September 2010

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Pyrido pyrimidinones as selective agonists of the high affinity niacin receptor GPR109A: optimization of in vitro activity.
Jens-Uwe Peters, Holger Kühne, Henrietta Dehmlow, Uwe Grether, Aurelia Conte, Michael Otteneder

Bioorg Med Chem Lett· September 2010

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Nonclinical pharmacokinetics of oseltamivir and oseltamivir carboxylate in the central nervous system.
Gerhard Hoffmann, Christoph Funk, Stephen Fowler, Michael B Otteneder, Alexander Breidenbach

Antimicrob Agents Chemother· November 2009

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In vivo oxidative metabolism of a major peroxidation-derived DNA adduct, M1dG.
Michael B Otteneder, Charles G Knutson, J Scott Daniels, Muhammed Hashim, Brenda C Crews

Proc Natl Acad Sci U S A· April 2006

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