Publications by authors named "Michael Pollastri"

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Optimization of Physicochemical Properties and ADME for 2,4-Substituted 1-Pyrrolo[2,3]pyridines Inhibitors of Trypanosome Proliferation.
Kelly A Bachovchin, Rosario Díaz, Gloria Ceballos-Perez, Domingo Rojas-Barros, Guiomar Pérez-Moreno, Michael P Pollastri

J Med Chem· October 2025

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Optimization of Quinazolines for Inhibition of Proliferation.
Sam Spijkers-Shaw, Pradip K Gadekar, Baljinder Singh, Gaurav Kumar, Amrita Sharma, Michael P Pollastri

ACS Med Chem Lett· September 2025

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Discovery and Early Optimization of 1-Indole-2-carboxamides with Anti- Activity.
Ramon G de Oliveira, Luiza R Cruz, Marco A Dessoy, Paul J Koovits, Deborah A Dos Santos, Michael P Pollastri

J Med Chem· April 2025

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Identification of Substituted 4-Aminocinnolines as Broad-Spectrum Antiparasitic Agents.
Andrew Spaulding, Amrita Sharma, Miriam A Giardini, Benjamin Hoffman, Jean A Bernatchez, Michael P Pollastri

ACS Infect Dis· March 2025

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Multiparameter ranking of carbazoles for anti-trypanosome lead discovery.
Amrita Sharma, Carlos E Sanz-Rodriguez, Michael P Pollastri, Andrei Purmal, Kojo Mensa-Wilmot

Front Drug Discov (Lausanne)· August 2024

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Pharmacophore Identification and Structure-Activity Relationship Analysis of a Series of Substituted Azaindoles as Inhibitors of .
Lori Ferrins, Rosario Diaz, Carlos Cordon-Obras, Domingo Rojas-Barros, Antonio Quotadamo, Michael P Pollastri

J Med Chem· August 2024

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Corrigendum: Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes.
Lori Ferrins, Melissa J Buskes, Madison M Kapteyn, Hannah N Engels, Suzanne E Enos, Michael P Pollastri

Front Microbiol· October 2023

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Structure-Property Optimization of a Series of Imidazopyridines for Visceral Leishmaniasis.
Maria Dichiara, Quillon J Simpson, Antonio Quotadamo, Hitesh B Jalani, Anson X Huang, Michael P Pollastri

ACS Infect Dis· August 2023

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Synthesis of a DNA-Encoded Macrocyclic Library Utilizing Intramolecular Benzimidazole Formation.
Jing Chai, Christopher C Arico-Muendel, Yun Ding, Michael P Pollastri, Sarah Scott

Bioconjug Chem· June 2023

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Identification of novel anti-amoebic pharmacophores from kinase inhibitor chemotypes.
Lori Ferrins, Melissa J Buskes, Madison M Kapteyn, Hannah N Engels, Suzanne E Enos, Michael P Pollastri

Front Microbiol· May 2023

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Chemical Optimization of CBL0137 for Human African Trypanosomiasis Lead Drug Discovery.
Baljinder Singh, Amrita Sharma, Naresh Gunaganti, Mitch Rivers, Pradip K Gadekar, Michael P Pollastri

J Med Chem· February 2023

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Physiologic Targets and Modes of Action for CBL0137, a Lead for Human African Trypanosomiasis Drug Development.
Carlos E Sanz-Rodríguez, Benjamin Hoffman, Paul J Guyett, Andrei Purmal, Baljinder Singh, Michael P Pollastri

Mol Pharmacol· July 2022

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Application of l-Threonine Aldolase to on-DNA Reactions.
Jing Chai, Xiaojie Lu, Christopher C Arico-Muendel, Yun Ding, Michael P Pollastri

Bioconjug Chem· September 2021

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Lead Optimization of 3,5-Disubstituted-7-Azaindoles for the Treatment of Human African Trypanosomiasis.
Dana M Klug, Eftychia M Mavrogiannaki, Katherine C Forbes, Lisseth Silva, Rosario Diaz-Gonzalez, Michael P Pollastri

J Med Chem· July 2021

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Medicinal Chemistry Optimization of a Diaminopurine Chemotype: Toward a Lead for Inhibitors.
Baljinder Singh, Rosario Diaz-Gonzalez, Gloria Ceballos-Perez, Domingo I Rojas-Barros, Naresh Gunaganti, Michael P Pollastri

J Med Chem· September 2020

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Structure-property studies of an imidazoquinoline chemotype with antitrypanosomal activity.
Dana M Klug, Rosario Diaz-Gonzalez, Travis J DeLano, Eftychia M Mavrogiannaki, Melissa J Buskes, Michael P Pollastri

RSC Med Chem· August 2020

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Hit-to-Lead Optimization of Benzoxazepinoindazoles As Human African Trypanosomiasis Therapeutics.
Dana M Klug, Laura Tschiegg, Rosario Diaz, Domingo Rojas-Barros, Guiomar Perez-Moreno, Michael P Pollastri

J Med Chem· March 2020

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Scaffold and Parasite Hopping: Discovery of New Protozoal Proliferation Inhibitors.
Baljinder Singh, Jean A Bernatchez, Laura-Isobel McCall, Claudia M Calvet, Jasmin Ackermann, Michael P Pollastri

ACS Med Chem Lett· March 2020

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Structure-Bioactivity Relationships of Lapatinib Derived Analogs against .
Melissa J Buskes, Monica Clements, Kelly A Bachovchin, Hitesh B Jalani, Allison Leonard, Michael P Pollastri

ACS Med Chem Lett· March 2020

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Selectivity and Physicochemical Optimization of Repurposed Pyrazolo[1,5-]pyridazines for the Treatment of Human African Trypanosomiasis.
Westley F Tear, Seema Bag, Rosario Diaz-Gonzalez, Gloria Ceballos-Pérez, Domingo I Rojas-Barros, Michael P Pollastri

J Med Chem· January 2020

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Evaluation of a class of isatinoids identified from a high-throughput screen of human kinase inhibitors as anti-Sleeping Sickness agents.
Dana M Klug, Rosario Diaz-Gonzalez, Guiomar Pérez-Moreno, Gloria Ceballos-Pérez, Raquel García-Hernández, Michael P Pollastri

PLoS Negl Trop Dis· February 2019

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Improvement of Aqueous Solubility of Lapatinib-Derived Analogues: Identification of a Quinolinimine Lead for Human African Trypanosomiasis Drug Development.
Kelly A Bachovchin, Amrita Sharma, Seema Bag, Dana M Klug, Katherine M Schneider, Michael P Pollastri

J Med Chem· January 2019

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Anilinoquinoline based inhibitors of trypanosomatid proliferation.
Lori Ferrins, Amrita Sharma, Sarah M Thomas, Naimee Mehta, Jessey Erath, Michael P Pollastri

PLoS Negl Trop Dis· November 2018

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Series of Alkynyl-Substituted Thienopyrimidines as Inhibitors of Protozoan Parasite Proliferation.
Jennifer L Woodring, Ranjan Behera, Amrita Sharma, Justin Wiedeman, Gautam Patel, Michael P Pollastri

ACS Med Chem Lett· October 2018

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Corrigendum to "Optimization of physicochemical properties for 4-Anilinoquinazoline inhibitors of trypanosome proliferation" [Eur. J. Med. Chem. 141 (2017) 446-459].
Jennifer L Woodring, Kelly A Bachovchin, Kimberly G Brady, Mitchell F Gallerstein, Jessey Erath, Michael P Pollastri

Eur J Med Chem· May 2018

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