Publications by authors named "Andrei Purmal"

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A phase 1 study of intra-arterial CBL0137 in extremity melanomas and sarcomas.
Joseph J Skitzki, Minhyung Kim, Daniel T Fisher, John M Kane, Han Yu, Andrei Purmal

Surg Oncol· August 2025

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The cell-permeable iron chelator M606 inhibits MYCN-driven neuroblastoma via an E2F3-mediated response.
Ruby Pandher, Chengyuan Xue, Laura D Gamble, Giorgio Milazzo, Simone Di Giacomo, Andrei A Purmal

Proc Natl Acad Sci U S A· June 2025

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FACT inhibitor CBL0137, administered in an optimized schedule, potentiates radiation therapy for glioblastoma by suppressing DNA damage repair.
Tara A Barone, Denisha L Robinson, Jingxin Qiu, Katerina V Gurova, Andrei A Purmal

J Neurooncol· December 2024

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FACT inhibitor CBL0137, administered in an optimized schedule, potentiates radiation therapy for glioblastoma by suppressing DNA damage repair.
Tara A Barone, Denisha L Robinson, Jingxin Qiu, Katerina V Gurova, Andrei A Purmal

Res Sq· September 2024

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Multiparameter ranking of carbazoles for anti-trypanosome lead discovery.
Amrita Sharma, Carlos E Sanz-Rodriguez, Michael P Pollastri, Andrei Purmal, Kojo Mensa-Wilmot

Front Drug Discov (Lausanne)· August 2024

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Chemical Optimization of CBL0137 for Human African Trypanosomiasis Lead Drug Discovery.
Baljinder Singh, Amrita Sharma, Naresh Gunaganti, Mitch Rivers, Pradip K Gadekar, Andrei Purmal

J Med Chem· February 2023

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Physiologic Targets and Modes of Action for CBL0137, a Lead for Human African Trypanosomiasis Drug Development.
Carlos E Sanz-Rodríguez, Benjamin Hoffman, Paul J Guyett, Andrei Purmal, Baljinder Singh

Mol Pharmacol· July 2022

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A deimmunized and pharmacologically optimized Toll-like receptor 5 agonist for therapeutic applications.
Vadim Mett, Oleg V Kurnasov, Ivan A Bespalov, Ivan Molodtsov, Craig M Brackett, Andrei A Purmal

Commun Biol· April 2021

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Prevention of Colorectal Carcinogenesis by DNA-Binding Small-Molecule Curaxin CBL0137 Involves Suppression of Wnt Signaling.
Kirill Kirsanov, Timur Fetisov, Ekaterina A Lesovaya, Varvara Maksimova, Lubov Trukhanova, Andrei A Purmal

Cancer Prev Res (Phila)· January 2020

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Curaxin CBL0137 has the potential to reverse HIV-1 latency.
Maxime J Jean, Dawei Zhou, Guillaume Fiches, Weili Kong, Huachao Huang, Andrei Purmal

J Med Virol· August 2019

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Curaxin CBL0100 Blocks HIV-1 Replication and Reactivation through Inhibition of Viral Transcriptional Elongation.
Maxime J Jean, Tsuyoshi Hayashi, Huachao Huang, Justin Brennan, Sydney Simpson, Andrei Purmal

Front Microbiol· October 2017

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Initial testing (stage 1) of the curaxin CBL0137 by the pediatric preclinical testing program.
Richard Lock, Hernan Carol, John M Maris, E Anders Kolb, Richard Gorlick, Andrei Purmal

Pediatr Blood Cancer· April 2017

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Genotoxicity of two new carbazole derivatives with antifungal activity.
Aliy K Zhanataev, Natalya V Eremina, Zlata V Chayka, Vasily I Kazey, Ekaterina L Andrianova, Andrei A Purmal

Mutat Res Genet Toxicol Environ Mutagen· April 2017

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Anticancer drug candidate CBL0137, which inhibits histone chaperone FACT, is efficacious in preclinical orthotopic models of temozolomide-responsive and -resistant glioblastoma.
Tara A Barone, Catherine A Burkhart, Alfiya Safina, Gary Haderski, Katerina V Gurova, Andrei A Purmal

Neuro Oncol· February 2017

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Erratum: Discovery of a Carbazole-Derived Lead Drug for Human African Trypanosomiasis.
Sarah M Thomas, Andrei Purmal, Michael Pollastri, Kojo Mensa-Wilmot

Sci Rep· January 2017

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ARTIK-52 induces replication-dependent DNA damage and p53 activation exclusively in cells of prostate and breast cancer origin.
Daria Fleyshman, Peter Cheney, Anda Ströse, Shaila Mudambi, Alfiya Safina, Andrei Purmal

Cell Cycle· December 2016

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Preclinical Validation of a Single-Treatment Infusion Modality That Can Eradicate Extremity Melanomas.
Minhyung Kim, Nickolay Neznanov, Chandler D Wilfong, Daria I Fleyshman, Andrei A Purmal

Cancer Res· November 2016

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Discovery of a Carbazole-Derived Lead Drug for Human African Trypanosomiasis.
Sarah M Thomas, Andrei Purmal, Michael Pollastri, Kojo Mensa-Wilmot

Sci Rep· August 2016

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The Toll-Like Receptor 5 Agonist Entolimod Mitigates Lethal Acute Radiation Syndrome in Non-Human Primates.
Vadim I Krivokrysenko, Ilia A Toshkov, Anatoli S Gleiberman, Peter Krasnov, Inna Shyshynova, Andrei A Purmal

PLoS One· June 2016

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Pharmacological Targeting of the Histone Chaperone Complex FACT Preferentially Eliminates Glioblastoma Stem Cells and Prolongs Survival in Preclinical Models.
Josephine Kam Tai Dermawan, Masahiro Hitomi, Daniel J Silver, Qiulian Wu, Poorva Sandlesh, Andrei A Purmal

Cancer Res· April 2016

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Therapeutic targeting of the MYC signal by inhibition of histone chaperone FACT in neuroblastoma.
Daniel R Carter, Jayne Murray, Belamy B Cheung, Laura Gamble, Jessica Koach, Andrei Purmal

Sci Transl Med· November 2015

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Small-molecule xenomycins inhibit all stages of the Plasmodium life cycle.
Jessey Erath, Julio Gallego-Delgado, Wenyue Xu, Grasiella Andriani, Scott Tanghe, Andrei Purmal

Antimicrob Agents Chemother· March 2015

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Identification of granulocyte colony-stimulating factor and interleukin-6 as candidate biomarkers of CBLB502 efficacy as a medical radiation countermeasure.
Vadim I Krivokrysenko, Alexander N Shakhov, Vijay K Singh, Frederick Bone, Yevgeniy Kononov, Andrei Purmal

J Pharmacol Exp Ther· November 2012

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Targeting FACT complex suppresses mammary tumorigenesis in Her2/neu transgenic mice.
Igor E Koman, Mairead Commane, Geraldine Paszkiewicz, Bhupinder Hoonjan, Srabani Pal, Andrei A Purmal

Cancer Prev Res (Phila)· August 2012

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CBLB613: a TLR 2/6 agonist, natural lipopeptide of Mycoplasma arginini , as a novel radiation countermeasure.
Vijay K Singh, Elizabeth J Ducey, Oluseyi O Fatanmi, Pankaj K Singh, Darren S Brown, Andrei Purmal

Radiat Res· May 2012

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